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IDFP

IDFP ne organophosphorus fili cewa dually inhibits MAGL da FAAH da IC50 dabi'u na 0.8 da 3 nm, respectively.1 A 10 MG / kg, IDFP elevates kwakwalwa matakan 2-AG kuma AEA fiye 10-Musulunci, da kuma rage-rage matakan arachidonic acid bya irin wannan girma. A endocannabinoids, 2-arachidonoyl glycerol (2-AG) da kuma arachidonoyl ethanolamide (AEA), su ne ilimin aiki lipids cewa gwada bambancin neurological da kuma na rayuwa ayyuka da kunna cannabinoid rabe, tsakiyar cannabinoid (CB1) da kuma na gefe cannabinoid (CB2). Maganin Monoacylglycerol (MAGL) da kuma fatty acid amidehydrolase (FAAH) sun yi amfani da 2-AG da AEA tare da haka, don haka sun dakatar da ayyukansu.

Samfur Description

 

IDFP bidiyo

 

 


 

I.IDFP ainihin Maƙallan:

 

name: IDFP
CAS: 615250-02-7
Tsarin kwayoyin halitta: C15H32FO2P
Girman kwayoyin halitta: 294.391
Shawarwar Melt:
Ajiye Temp: -20 ° C
Color:

 


 

II. IDFP sake zagayowar

 

1.Names:

Sunaye masu suna: ISOPROPYL DODECYLFLUOROPHOSPHONATE
Synonym:
IDFP; ISOPROPYL DODECYLFLUOROPHOSPHONATE; P-DODECYL-1-METHYLETHYL ESTER-PHOSPHONOFLUORIDIC ACID

 

2. Taimakon IDFP:

IDFP wani sashin kwayar halitta ne wanda yake da alaka da sarin mai azabar. Kamar sarin, IDFP wani mai hanawa ne wanda ba zai iya canzawa ba saboda yawancin enzymes daban-daban waɗanda suke amfani da shi don karya sassan neurotransmitters, duk da haka sarkar IDNP na tsawon lokaci yana da rauni sosai a matsayin mai hanawa acetylcholinesterase (AChE), tare da IC50 na 6300nM kawai, yayin da shi ne wani m hanawa na biyu enzymes monoacylglycerol lipase (MAGL), da farko enzyme alhakin wulakantar da endocannabinoid 2-arachidonoylglycerol (2-AG), kuma m acid amide hydrolase (FAAH), da farko enzyme cewa rage sauran babban endocannabinoid anandamide . IC50 na IDFP shine 0.8nM a MAGL, da 3.0nM a FAAH. Tsarin waɗannan enzymes guda biyu ya haifar da karuwar matakan da anandamide da 2-AG a cikin kwakwalwa, wanda ya haifar da alamar cannabinoid da kuma halayyar al'ada ta al'ada a cikin nazarin dabba, yayin da rashin ƙarfin aiki a AChE yana nufin cewa babu wani bayyanar cututtuka da ake kira cholinergic. [1 ] [2] [3] [4] Duk da irin tsarin sunadarai da aka yi da magungunan nervan da aka haramta, sashen IDFP na tsawon lokaci ya sa ya fadi a waje da ma'anar "sunadarai masu guba" a karkashin Takaddun Makamai na Mechanics, [5] da tun lokacin Har ila yau, ba ya nuna haɓakar AChE mai mahimmanci game da mahaɗar magungunan organophosphorus, IDFP ba ta da mahimmancin ikon sarrafa dokoki.

3.Wene ne sashin IDFP?

Don ajiyar lokaci mai tsawo, muna bayar da shawarar cewa an adana IDFP kamar yadda aka bayar a -20 ℃. Ya kamata ya zama barga don akalla shekara guda.
Ana bayar da IDFP a matsayin bayani a cikin acetate methyl. Don canza yadudduka, kawai kawar da acetate na methyl a ƙarƙashin wani ruwa mai sauƙi na nitrogen kuma nan da nan ya ƙara yawan yaduwar zaɓuɓɓuka. Wasu abubuwa irin su éthanol, DMSO, da dimethyl formamide sun tsarkaka tare da gas mai inerta za'a iya amfani dashi. Dalili na IDFP a cikin wadannan maganin sune kamar 10mg / ml.
Idan ana buƙatar gyaran maganin ruwa don nazarin halittu, za a iya shirya su da kyau ta hanyar diluting kwayoyin sunadarai a cikin kwakwalwa masu guba ko salin isotonic. Yi la'akari da cewar yawancin kwayoyin halitta ba su da muhimmanci, tun da kwayoyin sunadarai na iya samun tasirin ilimin lissafi a ƙananan raga. ba bayar da shawarar adana bayanai mai mahimmanci fiye da ɗaya ba.

4.How IDFP yana aiki?

IDFP wani mai hanawa ne wanda ba zai yiwu ba saboda yawancin enzymes daban-daban wanda ke amfani da shi don karya sassan neurotransmitters, duk da haka sarkar IDNP na tsawon lokaci ya zama mai raunana a matsayin mai hanawa acetylcholinesterase (AChE), yayin da yake mai hana mai kwakwalwa biyu na enzymes monoacylglycerol lipase ( MAGL), ƙananan enzyme da ke da alhakin lalata 2-arachidonoylglycerol endocannabinoid (2-AG), da kuma fatty acid amide hydrolase (FAAH), ƙananan enzyme wanda ya lalata wasu manyan abubuwan da ake danganta shi da anandamide. Wani fili na organophosphorus wanda ya hana MAGL da FAAH tare da dabi'u na IC50 na 0.8 da 3 nM, da dai sauransu.1 A 10 MG / kg, IDFP yana ɗauke da nauyin kwakwalwa ta 2-AG da AEA fiye da 10, da kuma rage matakai na arachidonic acid 10-ninka.

 

5.Warning:

Wannan samfurin ba don amfanin mutum bane ko amfani da dabbobi, gargadi har yanzu yana cikin binciken. Ka guji hulɗar kai tsaye tare da fata, idanu, bangare na numfashi, kowane rashin jin daɗi, kira likitanka a nan gaba.

 

6.IDFP Raw:

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mai girma zai iya aikawa a cikin kwanakin 3 aiki bayan biya.

 

7.IDFP Rashin Farin Cakuda:

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

 

8.IDFP Marketing:

Da za a bayar da shi a nan gaba.

 

9.Does IDFP Shin Dukkan Hanya?

Gwargwadon ƙwayar da aka yi, wanda yayi la'akari da ka'idojin gishiri da daidaitaccen ruwa da kuma rikici na tsawon lokaci, an wadatar da shi a cikin anandamide da biyu daga cikin manyan enzymes na metabolizing, cyclooxygenase-2 (COX-2) da fatty acid amide hydrolase (FAAH) . Jiko na anandamide (15, 30, kuma 60 nmol · min-1 · kg-1) a cikin koda medulla na C57BL / 6J beraye kara kuzari diuresis da gishiri tukar tumbi a Cox-2- amma ba Cox-1-dogara hanya. Don ƙayyade ko endocannabinoids masu fama da cutar a cikin ƙananan ƙwayar halitta za su iya haifar da irin wannan sakamako, sakamakon ilimin intopedullary isopropyl dodecyl fluorophosphate (IDFP), wadda ke hana manyan manyan endocannabinoid hydrolases, an yi nazarin. Cutar IDFP ta ƙara yawan ƙwayar fitsari da kuma ƙwayar sodium a cikin COX-2- amma ba hanyar COX-1 ba. Babu wani katako ko IDFP da ya shafi nauyin kuɗi. Ba na tsari (0.625 MG · kg-1 · 30 min-1 iv) kuma intramedullary (15 nmol · min-1 · kg-1 · 30 min-1) IDFP pretreatment kafin intramedullary anandamide (15-30 nmol · min-1 · kg-1) abubuwan da aka katange anandamide, wanda ya bada shawara cewa hydrolysis na anandamide ba dole ba ne don sakamako na diuretic. IDFP na Intramedullary ba shi da tasiri a kan yaduwar jini amma ya zubar da jinin jini. Sakamakon IDFP a kan tsawan jini da kuma tsabar jinin jini yana dogara ne akan FAAH-dogara kamar yadda aka nuna ta amfani da ƙwararrakin FAAH knockout. Analysis na linzamin kwamfuta urinary PGE2 yawa da HPLC-electrospray ionization jummai taro spectrometry nuna cewa IDFP magani rage urinary PGE2 Wadannan bayanai sun yi daidai da wani muhimmancin FAAH da kuma na ciki anandamide aiki ta Cox-2-dogara metabolite don tsara diuresis da gishiri tukar tumbi a cikin mousekidney.

 


 

III. IDFP HNMR

 

Mu ne mai kwakwalwan foda, Fayaccen foda don sayarwa, Raw Aprepitant foda (170729-80-3) hplc ma98% | AASraw R & D masu amsa

 


 

IV. Yadda ake saya IDFP daga AASraw?

 

1.To tuntube mu ta hanyar imel ɗinmutsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

 


 

Ganin shafukan samfurinka da kafi so:

 

 Mata Viagra? Dukkanin jima'i haɓaka Flibanserin foda Yadda ake amfani da Clenbuterol don asarar nauyi Mene ne nandrolone foda amfani da / nandrolone amfani?

 


 

Karin bayani game da samfurori masu dacewa,maraba don danna nan.


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