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JW 642

Endocannabinoids kamar 2-arachidonoyl glycerol (2-AG) da kuma arachidonoyl ethanolamide sune kwayoyin halitta masu aiki da ke aiki a cikin wasu hanyoyin synaptic ciki har da kunna masu karɓa na cannabinoid. JW 642 mai kirki ne mai rikitarwa na launi na monoacylglycerol (MAGL) wanda ya nuna dabi'u na IC50 na 7.6, 14, da kuma 3.7 nM na hana MAGL a cikin linzamin kwamfuta, bera, da kuma kwakwalwa na kwakwalwa na mutum. JW642is zabi don MAGL, yana buƙatar yawancin haɓaka don hana hawan gwanin fatty acid amide (IC50s = 31, 14, da 20.6 μM don linzamin kwamfuta, bera, da kwakwalwa ta kwakwalwa).

Samfur Description

 

JW 642 bidiyo

 

 


 

I.JW 642 ainihin Maƙallan:

 

name: JW 642
CAS: 1416133-89-5
Tsarin kwayoyin halitta: C21H20F6N2O3
Girman kwayoyin halitta: 462.4
Shawarwar Melt:
Ajiye Temp: a -20 ° C 3 shekaru Foda
Color: White m

 


 

II. JW 642 sake zagayowar

 

1. Sunaye:

Sunanan sunayen:
4 - [(3-Phenoxyphenyl) methyl] -1-piperazinecarboxylic acid 2,2,2-trifluoro-1- (trifluoromethyl) ethyl ester
Kamancin:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

 

2. JW 642 Amfani:

A cikin hanyoyin gwaje-gwaje, don tanadin lokaci na ajiya, muna bada shawarar cewa JW 642be adana shi ne -20 ℃. Ya kamata ya zama barga don akalla shekara guda.
An bayar da JW 642 a matsayin mafita a acetate methyl. Don canza yadudduka, kawai kawar da acetate na methyl a ƙarƙashin wani ruwa mai sauƙi na nitrogen kuma nan da nan ya kara yawan ƙananan zabi. Za a iya amfani da magungunan irin su asethanol, DMSO, da dimethyl formamide tare da gas mai iner. Halin JW 642 a cikin wadannan ƙananan abubuwa kusan 13,5, da kuma 11mg / ml.
JW 642 ne mai sauƙi mai narkewa a cikin masu bugun zuciya. Domin matsakaicin iyakancewa a cikin ruwa mai mahimmanci, zabin bayani na JW 642should za a shafe shi tare da maƙalar buƙatu mai tsami. JW 642 yana da matsala ta kimanin 0.3 mg / ml a cikin 1: 2 bayani na ethanol: PBS (pH 7.2) ta yin amfani da wannan hanya. Ba mu bayar da shawarar adana bayani mai mahimmanci fiye da ɗaya ba.

 

3.Wene ne jigidar JW 642?

DMSO zuwa 100 mM
Ethanol zuwa 100 mM
Bayanin Stability and Solubility Advice: Wasu mafita zai iya zama da wuya a samu kuma za'a iya ƙarfafawa ta hanyar motsawa, sonication ko mai dadi mai kyau (a cikin 45-60 ° C ruwa na ruwa). Bayani game da zaman lafiyar samfurin, musamman a cikin bayani, ya kasance da wuya a bayar da rahoto kuma a mafi yawancin lokuta muna iya ba da jagora mai girma. Shawarwarinmu na yau da kullum sune: SOLIDS: Idan aka tanadar ajiya kamar yadda aka bayyana a kan lakabin samfurin kuma an kulle shi da kulli, ana iya adana samfurin don zuwa watanni 6 daga ranar da aka samu. ABUBUWAN: Muna bayar da shawarar cewa an adana mafitacin jari, a shirye-shiryen, an ajiye su a cikin ƙananan haske -20 ° C ko ƙasa kuma ana amfani dashi a cikin watan 1. A duk inda za a iya samun mafita za a yi amfani da shi a rana guda.

 

4.Howne JW 642 ke aiki?

JW 642 mai kirki ne mai sukar lamarin monoacylglycerol lipase (MAGL) (IC = 3.7 nM). Nuni> 1000-ninka zabi ga MAGL akan fatty acid amidehydrolase (IC = 20.6 μM). Maganin Monoacylglycerol (MAGL) isa serine hydrolase da alhakin hydrolysis na 2-AG zuwa arachidonic acid da glycerol, ta haka ne ta ƙare aikin aikin halitta. Harkokin Toxicological iya haifar da su kamar ƙasa: Methyl Acetate - Bayanin Raɗaɗɗen Bayanai: Oral LD50 (bera):> 5,000 mg / kg; Oral LD50 (zomo): 3,705 MG / kg; Skin LD50 (zomo):> 5,000 mg / kg; Inhalation TCLO (ɗan adam): 15,000 mg / m3; Methyl Acetate - Bayanin Juyayi: Skin (zomo): 500 MG (24h) m; Eyes (zomo): 100 MG (24h) matsakaici.

 

5.Warning:

I.Stability da amsawa

5.1 Reactivity

Stable a ƙarƙashin jagorancin shawarar ko yanayin ajiya.

5.2 Tsarin lafiyar jiki

Stable a ƙarƙashin yanayin yanayin ajiya.

5.3 Rashin yiwuwar halayen haɗari

Hanyoyin halayen haɗari ba zasu faru ba a cikin yanayin sufuri ko yanayin ajiya. Shawarwarin zai iya faruwa a kan yadawa zuwa yanayin ko kayan da aka lissafa a ƙasa.

5.4 Yanayi don kaucewa zafi, danshi.
5.5 Matakan da ba a dace ba

M acid / alkalis, mai karfi oxidising / rage jamiái.

5.6 Hanyoyi masu lalatawa

A cikin konewa na iya fitar da furo mai guba. Babu bayanin da ba'a sani ba.

II.Handing da ajiya

5.1 Tsaro don kare lafiyar

Yi amfani dashi a cikin ɗakin shafewar jiki, tare da iskar da iska ke ba ta tsarin zaman kanta. Ka guji shafawa, tuntube tare da idanu, fata da kuma
tufafi. Ka guji samuwar ƙura da aerosols. Yi amfani dashi a yankin da aka ji daɗi. Ka guje wa maɓallin wuta. Guji
shafe tsawon ko maimaitawa.

5.2 Yanayi don ajiyar ajiya, ciki har da wani incompatibilities.

Store a cikin sanyi, da-ventilated yankin. Tsaya daga hasken rana kai tsaye. Rike akwati a rufe har sai an shirya don amfani.
Da'awar ajiya mai adanawa: Ajiye a -20 ° C

5.3 Ƙayyadaddun amfani yana amfani

Yi amfani dashi a cikin dakin gwaje-gwaje a dakin gwaje-gwaje inda za ta yiwu.

 

6.JW 642 Raw:

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mai girma zai iya aikawa a cikin kwanakin 3 aiki bayan biya.

 

7.JW 642 Shafin Farko:

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

 

8.JW 642 Marketing:

Da za a bayar da shi a nan gaba.

 

9.Does JW 642 Shin Dukkan Hanya?

Abubuwa na iya zama fushi ga ƙwayoyin mucous da ƙananan respiratory; Zai iya zama cutarwa ta hanyar inhalation, ingestion, ko kuma fata; Zai iya haifar da lalacewa; Zai iya haifar da fata ko numfashi na numfashi. Magancewa mai maimaitawa zai iya haifar da bushewa na fata ko fatalwa.
Gudanar da fitarwa / kariya ta sirri

9.1 Control sigogi

Kayan aiki tare da matakan sarrafawa
Bai ƙunshi wani abu tare da iyakokin iyakokin ɗaukar iyakar sana'a ba.

9.2 Exposure controls

Gudanar da aikin injiniya
Yi amfani dashi a cikin gidan fum din inda ya dace. Tabbatar da dukkan matakan aikin injiniya da aka bayyana a karkashin sashin 7 na SDS suna cikin wuri.
Tabbatar cewa dakin gwaje-gwaje an sanye shi tare da wankewar wankewa da wanke wanka.
Abubuwan kariya na sirri

Kariyar ido / fuska
Yi amfani da tabarau masu tsaro masu dacewa.
Kariyar kariya
Yi amfani da safofin rigakafi masu dacewa masu dacewa (mafi ƙarancin abin da ake buƙata ya dace BS EN 374: 2003). Gilashin ya kamata
an bincika kafin amfani. Yi wanke da ƙafa hannun hannu bayan an gama aiki.
Kariyar jiki
Sanya tufafi masu dacewa.
numfashi kariya
Idan kimar haɗari ya nuna dole, amfani da respirator dace.

al da sauransu

 


 

III. JW 642 HNMR

 

Mu ne mai kwakwalwan foda, Fayaccen foda don sayarwa, Raw Aprepitant foda (170729-80-3) hplc ma98% | AASraw R & D masu amsa

 


 

IV. Yadda za a sayi JW 642 daga AASraw?

 

1.To tuntube mu ta hanyar imel ɗinmutsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

 


 

Ganin shafukan samfurinka da kafi so:

 

 Mata Viagra? Dukkanin jima'i haɓaka Flibanserin foda Yadda ake amfani da Clenbuterol don asarar nauyi Mene ne nandrolone foda amfani da / nandrolone amfani?

 


 

Karin bayani game da samfurori masu dacewa,maraba don danna nan.


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