Cibiyar binciken cutar ta Alzheimer ta jawo hankalin wasu masu hankali a cikin bincike na likita a cikin shekaru 20 da suka gabata. Duk da yake masu bincike sun koyi abubuwa da yawa game da cututtukan cututtuka, da cututtuka, da magungunanta, an samu cigaba da yawa a kan yaki da cutar.

{Ungiyar ta biyo bayan wa] ansu miyagun kwayoyi J147 (1146963-51-0) ya yanke shawarar ɗauka daban-daban. Sakamakon farko ya kasance mai ban sha'awa, kuma masu bincike suna ci gaba da nazarin yadda wannan sababbin kwayoyi ke hulɗa da kwayoyin halitta daban-daban.


Mene ne J147?

J147 wani nau'i ne na farko da aka gina a 2011. Masu bincike sun gano cewa miyagun ƙwayoyi, a hanyoyi daban-daban, na iya canza ƙwayar ƙwaƙwalwar ajiya da jinkirin, ko ma baya, Alzheimer's in mice.

J147 foda ne phenyl hydrazide. An samo shi daga curry spice component curcumin. Yana da mummunan maye. Duk da damuwa da damuwa, J147 foda ba a nuna su zama carcinogenic ba. Masu bincike sun gwada da yawa saboda wannan yiwuwar ta hanyar nazarin wadanda ke cikin J147 a cikin kwayar cutar mutum da linzamin kwamfuta da kuma ƙwayar motsi.

Sakamakon ya nuna cewa J147 ba a haɗa shi zuwa amines ko hydrazines.


Hanyar gargajiya game da yakin Alzheimer

Yawancin kwayoyi da suka samo asali a cikin shekaru 20 da suka wuce an yi niyya akan amyloid plaque deposits a cikin kwakwalwan marasa lafiya na Alzheimer. Wannan tsari ya sa hankali mai mahimmanci saboda wadannan adadin su ne abin da ke rushe kwayoyin jikinsu har zuwa mutuwa.

Duk da haka, bayan shekaru 20 babu matukar cigaba a gwajin gwaji tare da wasu kwayoyi da suka sa ido kan takaddun shaida.

Hanyar da aka danganta ita ce ƙoƙari don gwada amyloid kafin ya samar da takaddun shaida. Amyloid yana lalata synapses kafin ya zama cikin kwakwalwa. Duk da haka, ko da wannan makasudin baya bai tabbatar da zama tasiri ba.

Har zuwa ci gaba da J147 (1146963-51-0), ainihin maganin Alzheimer ya kasance a tsaye. Babu wata hanyar da ta dace da duk wata kwayar da aka samu a cikin shekarun 20 da suka gabata da kuma cututtukan cututtuka da cutar kanta ba ta ba da kanta ga wasu hanyoyi masu kyau ba.


Yadda J147 (1146963-51-0) ke aiki akan Alzheimer

Kungiyar ta J147 ta yanke shawara ta dauki matakan dabara wajen yaki da Alzheimer's. Maimakon bunkasa wani magungunan da ake nufi da amyloid, kungiyar ta yanke shawarar mayar da hankali ga wani babban haɗari ga Alzheimer's. Babban matsala mafi girma shine tsoho - saboda haka tawagar ta juya kokarinta ga tsarin tsufa.

Ƙungiyar ta kirkiro J147 ta amfani da fuska ta wayar salula akan tsofaffin ƙwayoyin kwakwalwa. Daga waɗannan fuska, sun hada J147 foda.

A J147 foda aiki ta rage aikin ATP synthase a cikin mitochondria. Wannan kare kwayoyin neuronal daga yawancin abubuwan da ke cikin kwakwalwa. Bincike ya nuna dalilin da yasa wannan fili ke haifar da wannan tasirin ne saboda kaddamar da rashin takaici a cikin lalata kwayar cutar neuronal.

Kayan zuma za su zama lalacewa kuma ana kashe su ta hanyar kaucewa masu karɓar ragowar masu amfani da shi. J147 yana da jinkirin saukar da matakan da wasu tsofaffin ƙwayoyin kwakwalwa suka yi sauri. Wannan yana kiyaye ƙananan hanyoyi, kuma mafi mahimmanci, kuma zai iya haifar da sake juyayin wasu alamun Alzheimer.


J147 tana aiki a matsayin wakili mai tsufa

Ma'aikatan J147 ba kome ba ne kamar sauran kwayoyin Alzheimer da suka kai irin wannan bincike. Domin ba ya maida hankalin al'amuran gargajiya na cutar ba, amma yana aiki don magance haɗari da matsala ta tasowa.

J147 yayi aiki a matsayin wakili mai tsufa. Hagu zuwa na'urorinsa, kwakwalwar ɗan adam tana tasowa wasu abubuwa masu guba. Wadannan abubuwa ne wadanda ke haifar da yanayin da ke haifar da yanayin Alzheimer don bunkasa. J147 yana mayar da agogo a kan waɗannan abubuwa masu guba, wannan kuma ya sa wuya Alzheimer yayi aikinsa na ɓata tsarin ƙwaƙwalwar ajiya daban-daban.

Yana yiwuwa yiwuwar cewa J147 ya ba da gudunmawa don amfani da shi fiye da kawai yakin Alzheimer. Irin wadannan tsofaffi masu tsufa za su iya magance wasu cututtukan da ke haifar da wasu cututtuka da kuma cututtuka inda yawancin shekarun shine babban haɗari. J147 ba kawai maganin miyagun ƙwayoyi ne na Alzheimer ba. Yana da magungunan ƙwayoyi da ke taimakawa wajen sake tsufa.


J147 gwajinsu

Ko da yake an fara J147 ne a 2011, yanzu yana kusa da yarda ga gwajin gwaji. A kowane mataki a hanya, J147 ya nuna cewa ba wai kawai ya kasance mai tasiri sosai ba, amma an nuna shi ya zama barga.

Damuwa na farko game da yiwuwar J147 kasancewa mai cututtuka, ko kuma mai guba, an nuna rashin tushe.

Masu bincike suna da damuwa don samun gwaji a cikin gwaji kuma kusan duk wanda ke cikin bincike na Alzheimer yana da bege cewa J147 zai tabbatar da zama tasiri a cikin mutane kamar yadda yake a cikin ƙananan yara kuma a cikin gwaje-gwajen simulations.


Binciken J147 na farko

Da farko masu bincike sun gano cewa J147 (1146963-51-0) zai iya hana, da baya, ƙwaƙwalwar ƙwaƙwalwar ajiya a cikin ƙwararrun da ke da alamar Alzheimer's. Duk da haka, kamar yadda tsammanin wannan sakamakon ya kasance, a cikin mutane, kawai game da 1% na marasa lafiya na Alzheimer sun sami gado. Mafi yawan nau'ikan Alzheimer na hade ba tare da wani tsari na jinsi ba, amma tare da tsufa kanta.

Ƙungiyar ta fi nazarin sakamakon J147 a kan rukuni na ƙuda da ke da shekaru da sauri kuma suna fuskanci nau'in nakasar da ke kama da Alzheimer mai shekaru da aka samu a cikin mutane.

Sakamakon wannan binciken na biyu ya kasance alamar alkawarin. J147 ya iya ceton ƙarancin rashin lafiya, ko da lokacin da aka gudanar a farkon matakan cutar. Ya inganta ƙwaƙwalwar ajiya a cikin mice kuma ya hana kara lalacewa.

Haka kuma an gano cewa lokacin da aka hada J147 tare da donepezil ya yi aiki mafi kyau don sake mayar da ƙwaƙwalwar ajiya da cued. Amma, J147 kadai ya kasance mafi mahimmanci wajen sake mayar da hankali ga sararin samaniya.


Abin da Gidan Nan Ya Tsaya J147 (1146963-51-0)

Har yanzu akwai hanya mai tsawo kafin J147 (1146963-51-0) zai kasance don magance mafi yawan marasa lafiya na Alzheimer. Da farko dai miyagun ƙwayoyi dole ne ya kammala cikakke lokacin gwaji. Da zarar an gwada gwajin gwagwarmayar gwagwarmaya, tsarin aikin FDA zai fara.

Masu bincike suna tunawa da bukatar gaggawa don maganin cututtukan Alzheimer, amma kuma suna da tabbacin kada su gaggauta kimiyya. Ya zuwa yanzu, dukkanin sakamakon da J147 ke da shi na da kyau sosai kuma babu wani maganin miyagun ƙwayoyi na Alzheimer wanda ya taba ganin hakan a cikin wannan tsari.


Ƙarin game da J147:

Gwajin J147 Alzheimer na gwajin gwagwarmaya | AASraw


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