Tsarin J-147 na Curcumin ya bi AD, Tsarin tsufa, Ciwon Cutar (MDD)

J-147 Ra'ayoyin

Curcumin polyphenol ce kuma tana aiki ne da Turmeric da Ginger.Curcumin yana da fa'idodi da yawa da aka tabbatar dasu wajen magance cututtuka da yawa, amma saboda rashin karfin iya tsallake shingen Jini-Brain (BB), akwai iyakoki karara.

Ainihin, J147 (CAS:1146963-51-0) shine abin kirkirar Curcumin da Cyclohexyl-Bisphenol A (CBA) wanda ke da ƙwaƙƙwaran ƙwayoyin cuta da ƙwayoyin cuta. An haɓaka shi don amfani da yanayin kula da yanayin yanayin da ke tattare da tsufa. J147 na iya haye BBB cikin kwakwalwa (mai ƙarfi) kuma ya haifar da samar da kwayar halitta ta neuronal.

Ba kamar magungunan da aka yarda da su yanzu ba don cutar Alzheimer, J147 ba mai hana acetylcholinesterase bane ko kuma mai hana phosphodiesterase, duk da haka yana haɓaka haɓaka tare da ɗan gajeren magani.

A cikin wannan sakon, za mu tattauna yadda J147 wanda ke samar da curcumin ya magance cutar Alzheimer (AD), babbar cuta ta ɓacin rai (MDD) da Anti-tsufa.

Ga abubuwan da ke ciki:

1. Learnara koyo game da Aikin J-147 (Kayan aiki)
2. Fa'idodin Duba Saurin J-147
3. J-147 Bi da Cutar Alzheimer (AD)
4. J-147 Kula da Matsalar tsufa
5. J-147 Bi da Babban Rashin Ciwon Cutar (MDD)
6. Researcharin Bincike Game da J-147
7. Inda Sayi J-147 Foda

Learnara koyo game da Aikin J-147 (Kayan aiki)

Har zuwa shekarar 2018, tasirin J-147 akan kwayar halitta ya kasance abin ban mamaki har sai da Salk Institute Neurobiologists suka yanke hukunci. Magungunan yana aiki ta hanyar haɗuwa da ATP synthase. Wannan furotin na mitochondrial yana daidaita samar da kuzarin salula, don haka, yake sarrafa tsarin tsufa. Kasancewar karin J-147 a cikin tsarin dan adam yana hana cututtukan da suka shafi shekaru wadanda suke haifar da rashin aikin mitochondria da kuma yawan kayan ATP.

Tsarin J-147 na aiki kuma zai kara matakan wasu masu yada sakonnin kwakwalwa ciki har da NGF da BDNF. Bayan wannan, yana aiki ne akan matakan beta-amyloid, waɗanda koyaushe suna da yawa tsakanin marasa lafiya da Alzheimer da cutar rashin hankali. Ayyukan J-147 sun hada da rage ci gaban cutar Alzheimer, hana ragin ƙwaƙwalwar ajiya, da haɓaka samar da ƙwayoyin neuronal.

Fa'idodin Duba Saurin J-147

❶ Inganta Aikin Mitochondrial Da Tsawan rayuwa

Yana Hana Ciwon Alzheimer

❸ Inganta Memory

Rows Girma Brain

Kare jijiyoyin jiki

❻ Zai Iya Inganta Ciwon Suga

❼ Yaƙi Ciwo da Neuropathy

❽ Iya Inganta Damuwa

J-147 Bi da Cutar Alzheimer (AD)

J-147 da AD: Bayan Fage 

A halin yanzu, babban mahimmancin binciken kwayoyi don cututtukan cututtukan neurodegenerative ya dogara ne akan haɗakar ƙawancen haɗin kai don maƙasudin takamaiman cuta. Don cutar Alzheimer (AD), abin da aka fi mayar da hankali shi ne amyloid beta peptide (Ass) wanda ke yin sulhu tsakanin dangin Alzheimer na cutar. Koyaya, idan aka ba wannan shekarun shine mafi girman haɗarin AD, mun bincika wani makircin gano miyagun ƙwayoyi wanda ya dogara akan inganci a cikin ƙirar al'adun ƙwayoyin cuta da yawa game da cututtukan da ke tattare da shekaru maimakon na amyloid metabolism kawai. Amfani da wannan hanyar, mun gano wani mai ƙarfin gaske, mai yin magana, ƙwayoyin neurotrophic wanda ke sauƙaƙa ƙwaƙwalwar ajiya a cikin ƙwayoyi na yau da kullun, kuma yana hana asarar sunadaran synaptic da ƙin fahimi a cikin ƙirar ƙirar AD ta transgenic.

J 147 da AD: Binciken ƙididdigar gwaji akan Beraye

GABATARWA: Duk da yawan bincike na shekaru, babu wasu kwayoyi masu canza cuta don cutar Alzheimer (AD), mai saurin mutuwa, cuta mai alaƙa da shekaru. Nunawa don ƙwarewar ilimin likita a cikin sifofin ƙirar AD ya dogara gaba ɗaya akan mahaɗan gwaji kafin bayyanar cututtuka ta kasance, don haka yin samfurin rigakafin cutar maimakon gyara cuta. Bugu da ƙari kuma, wannan tsarin don nunawa ba ya nuna gabatarwar asibiti na marasa lafiya na AD wanda zai iya bayyana gazawar fassara mahaɗan da aka gano cewa suna da amfani a cikin dabbobin dabba zuwa cututtukan da ke sauya mahadi a gwajin asibiti. A bayyane yake ana buƙatar kyakkyawar hanya don binciken likita na asibiti don AD.

MUTANE: Don ƙarin dacewa sosai game da yanayin asibiti, munyi amfani da wata hanyar dabarun bincike wacce ta haɗa da kula da ƙwayoyin berayen AD a wani matakin cutar yayin da ilimin cuta ya riga ya ci gaba. Ya tsufa (ɗan wata 20) ɗan mushe AD (APP / swePS1DeltaE9) an ciyar da shi mai ƙwarewa, mai magana a hankali, haɓaka ƙwaƙwalwa da kwayar halittar neurotrophic da ake kira J147. An yi amfani da gwajin halayyar halayyar halayya, tarihin tarihi, ELISA da gogewar Yammaci don gwada tasirin J147 akan ƙwaƙwalwar ajiya, amyloid metabolism da hanyoyin neuroprotective. An kuma bincika J147 a cikin ƙirar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa a cikin ƙwayoyin C57Bl / 6J kuma idan aka kwatanta da didpezil. Detailsarin bayanai kan ilimin likitanci da amincin J147 an haɗa su.

Sakamakon: Bayanai da aka gabatar a nan sun nuna cewa J147 yana da ikon ceton rashi na hankali lokacin da aka gudanar a ƙarshen matakin cutar. Ikon J147 don haɓaka ƙwaƙwalwar ajiya a cikin tsofaffin ƙwayoyin AD sun haɗu tare da shigar da abubuwan neurotrophic NGF (haɓakar haɓakar jijiya) da BDNF (ƙwaƙwalwar da ke samo ƙwayar neurotrophic) da kuma sunadarai masu karɓar BDNF masu mahimmanci waɗanda ke da mahimmanci don ilmantarwa da ƙwaƙwalwa. Kwatanta tsakanin J147 da donepezil a cikin sifar scpolamine ya nuna cewa yayin da duka mahaɗan sun kasance kwatankwacin ceton ƙwaƙwalwar ajiyar ɗan gajeren lokaci, J147 ya kasance mafi girma wajen ceton ƙwaƙwalwar sararin samaniya kuma haɗuwa da su biyun sunyi aiki mafi kyau don ƙwaƙwalwar ajiya da ƙwaƙwalwar ajiya.

Kammalawa akan J-147 don AD

J147 sabon fili ne mai kayatarwa wanda yake da matukar ƙarfin gaske, mai aminci a karatun dabba da kuma aiki mai baka. J147 magani ne mai yuwuwa na AD saboda iyawar sa don samar da gaggawa fa'idar fa'ida, kuma har ila yau yana da damar dakatarwa kuma wataƙila ya sake ci gaba da cutar a cikin dabbobi masu alamomin kamar yadda aka nuna a cikin waɗannan karatun.

J-147 Kula da Matsalar tsufa

J-147 da Anti-tsufa: Bayan Fage 

Berayen da aka yiwa jiyya tare da J147 sun sami ƙwaƙwalwar ajiya da ƙwaƙwalwa, sun fi lafiya cikin jijiyoyin jini a cikin kwakwalwa da sauran abubuwan da suka dace da ilimin lissafi…

"Da farko, karfin gwiwa shi ne a gwada wannan magani a cikin samfurin dabba wanda ya yi kama da kashi 99 cikin XNUMX na al'amuran Alzheimer," in ji Antonio Currais, memba na Farfesa David Schubert's Laboratory Neurobiology Laboratory a Salk. “Ba mu yi hasashen cewa za mu ga irin wannan ba Anti-tsufa tasiri, amma J147 ya sanya tsoffin beraye su yi kamar sun kasance matasa, bisa ga wasu hanyoyin ilimin lissafi. ” "Duk da yake mafi yawan kwayoyi da aka kirkira a cikin shekaru 20 da suka gabata suna yin niyya ne ga amyloid plaque adibas a cikin kwakwalwa (wanda alama ce ta cutar), babu wanda ya tabbatar da inganci a asibitin," in ji Schubert.

Shekaru da dama da suka gabata, Schubert da abokan aikinsa sun fara tunkarar maganin cutar daga wata sabuwar hanya. Maimakon yin niyya ga amyloid, dakin gwaje-gwaje ya yanke shawarar ba komai a kan babban haɗarin haɗarin cutar - tsufa. Amfani da fuska mai ƙwayoyin jiki akan tsufa mai alaƙa da ƙwayoyin cuta, sun haɗa J147.

A baya, ƙungiyar ta gano cewa J147 na iya hanawa har ma da juyawar ƙwaƙwalwar ajiya da cutar Alzheimer a cikin ƙananan yara waɗanda ke da nau'ikan nau'in gadon Alzheimer, samfurin linzamin da aka fi amfani da shi. Koyaya, wannan nau'in cutar ya ƙunshi kusan 1% na al'amuran Alzheimer. Ga kowa da kowa, tsufa ita ce tushen haɗarin farko, in ji Schubert. Teamungiyar ta so ta bincika tasirin ɗan takarar miyagun ƙwayoyi a kan nau'in beraye waɗanda ke tsufa da sauri kuma suna fuskantar wani nau'in hauka wanda ya fi kamanceceniya da cutar ɗan adam da ke da shekaru.

J-147 da Anti-tsufa: Binciken ƙwarewar gwaji akan Beraye

A cikin wannan aikin na baya-bayan nan, masu binciken sun yi amfani da cikakkun matakai na gwaji don auna yadda dukkanin kwayoyin halitta ke cikin kwakwalwa, da kuma kanana kananan kwayoyin 500 da ke dauke da cutar metabolism a cikin kwakwalwa da jini na kungiyoyi uku na mice masu saurin tsufa. Groupsungiyoyi uku na berayen da ke saurin tsufa sun haɗa da saiti ɗaya wanda yake saurayi, saiti ɗaya tsoho da saiti ɗaya waɗanda suka tsufa amma sun ciyar da J147 kamar yadda suka tsufa.

Tsoffin beraye waɗanda suka karɓi J147 sun yi aiki mafi kyau a kan ƙwaƙwalwar ajiya da sauran gwaje-gwaje don ƙwaƙwalwa sannan kuma sun nuna mafi ƙarfin motsi na motsi. Berayen da aka kula da su J147 suma suna da ƙananan alamun alamun cutar Alzheimer a cikin kwakwalwar su. Mahimmanci, saboda yawan bayanan da aka tattara akan ƙungiyoyi uku na beraye, zai yiwu a nuna cewa yawancin fannonin bayyanar da kwayar halitta a cikin tsohuwar berayen da aka ciyar da J147 sun yi kama da na ƙananan dabbobi. Wadannan sun hada da alamomi don kara kuzarin kuzari, rage kumburin kwakwalwa da rage matakan kitsen mai mai kiba a kwakwalwa.

Wani sanannen tasirin shine J147 ya hana zuban jini daga microvessels a cikin kwakwalwar tsohuwar beraye. Currais ya ce "Lalacewar jijiyoyin jini wata alama ce ta tsufa gabaɗaya, kuma a cikin Alzheimer, cutar tana daɗa muni."

Kammalawa akan J-147 don matsalar tsufa

Berayen da aka ciyar da J147 sun kara karfin kuzari da kuma rage kumburin kwakwalwa.Masu bincike sun gano cewa wani dan takarar gwajin kwaya da nufin yakar cutar Alzheimer, da ake kira J147, yana da tarin abubuwan da ba tsammani anti-tsufa effects a cikin dabbobi.

Fromungiyar daga Cibiyar Salk ta nuna cewa ɗan takarar miyagun ƙwayoyi ya yi aiki sosai a cikin ƙirar linzamin kwamfuta na tsufa wanda yawanci ba a amfani da shi a cikin binciken Alzheimer. Lokacin da aka bi da waɗannan berayen tare da J147, suna da ƙwaƙwalwar ajiya da fahimi, da lafiyar jijiyoyin jini a cikin kwakwalwa da sauran ingantattun abubuwan ilimin lissafi.

J-147 Bi da Babban Rashin Ciwon Cutar (MDD)

J-147 da MDD: Bayan Fage

Babban mawuyacin hali (MDD) cuta ce mai zurfin ruhi da ke da alaƙa da rashi na ƙwayoyin cuta na kwayar halitta, musamman ma rashin dacewar 5-HT (5-hydroxytryptamine, serotonin) da masu karɓa. Bincikenmu na baya ya ba da shawarar cewa magani mai mahimmanci tare da labari Tsarin curcumin J147 nuna alamun antidepressant-kamar sakamako ta hanyar ƙara ƙwaƙwalwar da aka samo factor neurotrophic (BDNF) a cikin hippocampus na beraye. Binciken na yanzu ya fadada kan bincikenmu na baya kuma yayi bincike game da cututtukan da ke kama da cutar ta J147 na kwanaki 3 a cikin ƙananan yara ICR da yiwuwar dacewa ga masu karɓa na 5-HT1A da 5-HT1B da siginar CAMP-BDNF.

J-147 da MDD: Binciken ƙididdigar gwaji akan Beraye

Hanyar: J147 a cikin allurai na 1, 3, da 9 mg / kg (ta hanyar gavage) an gudanar da su tsawon kwanaki 3, kuma an yi rikodin lokacin hana motsa jiki a cikin tilasta yin iyo da gwajin dakatar da jela (FST da TST). Anyi amfani da gwajin gwajin radioligand don tantance dangantakar J147 zuwa 5-HT1A da mai karɓar 5-HT1B. Bugu da ƙari, an yi amfani da 5-HT1A ko 5-HT1B agonist ko abokin gaba don ƙayyade wane nau'in mai karɓar mai karɓar 5-HT da ke cikin ƙwayoyin cuta na antidepressant-kamar na J147. Hakanan an auna ƙwayoyin siginar ƙasa kamar su CAMP, PKA, pCREB, da BDNF don ƙayyade yanayin aikin.

results: Sakamakon binciken ya nuna cewa ƙaramin maganin J147 ya rage lokacin rashin motsi a duka FST da TST a cikin yanayin dogaro da kashi. J147 ya nuna babban dangantaka a cikin vitro zuwa mai karɓar 5-HT1A wanda aka shirya daga ƙwayoyin ƙwayoyin ƙwayaye kuma ba shi da ƙarfi a mai karɓar 5-HT1B. Wadannan tasirin J147 an katange su ta hanyar shiri tare da mai adawa 5-HT1A NAD-299 kuma an inganta shi ta hanyar agonist 5-HT1A 8-OH-DPAT. Koyaya, mai karɓar mai karɓar 5-HT1B NAS-181 bai nuna godiya ba game da canza tasirin J147 akan halaye na kama-ciki. Bugu da ƙari, yin shiri tare da NAD-299 an katange haɓakar J147 a cikin CAMP, PKA, pCREB, da BDNF a cikin hippocampus, yayin da 8-OH-DPAT ya inganta tasirin J147 akan waɗannan maganganun sunadaran.

Kammalawa akan J-147 don Babban Rashin Ciwon Cutar (MDD)

Sakamako ya nuna cewa J147 yana haifar da saurin antidepressant-kamar sakamako a yayin kwanakin kulawar kwanaki 3 ba tare da haifar da haƙuri da magani ba. Wadannan tasirin za a iya yin sulhu ta hanyar 5-HT1A-dependent dogara CAMP / PKA / pCREB / BDNF siginar.

Researcharin Bincike Game da J-147

T-006: Yadda Ake Yin Wannan Ingantaccen Canjin Zuwa J-147

J147 shine phenyl hydrazide wanda aka samo daga asalin mahaɗin curcumin.

J147 yana da rabin rai na awanni 2.5 a kwakwalwa, awanni 1.5 a plasma, 4.5min a cikin microsomes ɗan adam, da <4min a cikin microsomes na linzamin kwamfuta.

Maganin jiyya na yau da kullun tare da J147 ya kare jijiyar sciatic daga ci gaba da ciwon sukari wanda ke haifar da jinkirin jinkirin saurin haɓakar fiber yayin da allurai guda ɗaya na J147 cikin hanzari kuma cikin hanzari ya juya aka kafa ingantaccen allodynia.

J147 magani ya ƙaddara BACE, saboda haka haɓaka APP (ƙarancin APP ɓarkewa ƙarshe yana haifar da Aβ).

Mit oc-F1 mitochondrial of-F5 na ATP synthase (ATP147A) a matsayin babban haɗin ƙirar ƙirar J5, furotin da aka riga yayi nazari akan yanayin tsufa… yana da ƙoshin dogaro mai dogaro akan ATPXNUMXa.

J147 ya dawo da matakan acylcarnitines wanda ke ba da shawarar sakamako mai tasiri akan tasirin mitochondrial.

A cikin masu karɓar NMDA, T-006 yana hana yawan Ca2 + ambaliya.

-T-006 yana da rawar kariya a cikin wannan tsarin ta hanayar hanyar MAPK / ERK da maido da hanyar PI3-K / Akt.

Sauran abubuwan da suka samo asali kamar 3j (analog na maye gurbin J147 dicyanovinyl) na iya hana oligomerization da fibrillation na am-amyloid peptides kuma suna kare ƙwayoyin neuronal daga β-amyloid-jawo cytotoxicity.

Inda zan Sayi Foda J-147?

Doka ta wannan nootropic har yanzu ƙashin hankali ne amma hakan ba zai hana ku samun halattattun kayayyaki ba. Bayan haka, ana ci gaba da gwajin gwaji na J-147 Alzheimer. Kuna iya siyan foda a cikin shagunan kan layi yayin da kuka sami damar kwatanta farashin J-147 a tsakanin masu sayarwa daban-daban. Koyaya, yakamata ku tabbatar da siyayya daga masu samar da inganci tare da gwajin gwaji mai zaman kansa.

Idan kana son wasu J-147 don siyarwa, shiga tare da shagonmu. Mun samar da nootropics da yawa a ƙarƙashin kula da inganci. Kuna iya saya da yawa ko yin sayayya ɗaya dangane da burin zuciyar ku. Lura cewa, farashin J-147 na abokantaka ne kawai lokacin da ka sayi adadi da yawa.

reference

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