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Dolanatin 10 (110417-88-4)

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SKU: 110417-88-4. category:

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa umurnin taro na Dolastatin 10 (CAS 110417-88-4), a karkashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

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Samfur Description

Dolanatin 10 bidiyo


I.Dolastatin 10 na ainihi Abubuwan:

name: Dolanatin 10
CAS: 110417-88-4
Kwayoyin Formula: C42H68N6O6S
Girman kwayoyin halitta: 785.09g / mol
Shawarwar Melt: 94-95oC
Ajiye Temp: Ajiye a wuri mai sanyi da bushe kuma a 0 - 4 ℃ don gajeren lokaci (kwanaki zuwa makonni) ko -57 ℃ na tsawon lokaci (watanni zuwa shekaru)
Color: White zuwa kashe-farin sollid


II. Dolanatin 10 (110417-88-4) amfani da shi a cikin zagayowar antitumor

1. Sunaye:

Chemical name:
Dolastatin 10 (CAS 110417-88-4), Dolastatin-10, Neuro_000215, CCRIS 7310, CID100208, NSC376128,NSC 376128, C11280, L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

2.Dolastatin 10 Amfani:

Dalilin: Masanin kimiyya na likita ya bincika tasiri da mawuyacin magungunan anti-microtubule da ke dauke da kwayar cuta-10 a cikin marasa lafiya da ciwon ciwon daji.

Hanyar: Ashirin da daya marasa lafiya da ma'auni metastatic nono da aka bi da tare da dolastatin-10 a kashi na 400 mcg / m2 da igiyar jini bolus sau daya a kowace 3 makonni.

Sakamako: Daya daga cikin marasa lafiya na 21 (5%; 95% CI: 0-24%) ya sami gafarar jinkiri na tsawon kwanakin 113. Ma'aikata hudu sun kasance marasa lafiya a cikin kwakwalwa na kwanakin 87. Marasa lafiya sun sami nau'i na nau'i biyu na dolastatin-10. Maganin ilimin ilimin halitta yana da matsakaici, tare da marasa lafiya na 8 wadanda ke bunkasa 4 neutropenia, da 5 tare da nau'in 3 neutropenia; An lura da nau'in 3 na daidaitattun furotin. Wadannan sifofin na 3 da 4 neutropenia sun sami gogaggen a kan 36% na rawanin maganin. Ba a san abin da ya faru ba ne a cikin rashin ciwo.

Kammalawa: Yayinda ake yarda da maganganu na dolastatin-10, yana da ƙananan aiki a cikin binciken binciken ciwon nono na ci gaba.

A cikin Vitro: Dolastatin 10 na musamman ne wanda ke da mahimmanci na pentapeptide wanda ya ware daga kogin Dolabella auricularia. An founds cewa wadannan a vitro data ne quite m ga waɗanda na Dolastatin 10 da Auristatin PE, kowanne daga abin yana GI50 dabi'u na 10-5-10-6 μg / ml (10-2-10-3 NM) da wani irin minipanel na layin kwayoyin halitta. A antibody-miyagun ƙwayoyi conjugate (Dogarin) qunshi da anti-CD30 monoclonal antibody cAC10 conjugated ga cytotoxic wakili monomethyl auristatin E (MMAE), wani roba analog na tubulin Polymerization hanawa Dolastatin 10 (110417-88-4).

3.Warning akan Dolastatin 10

Wannan samfurin shine kawai don yin amfani da bincike, ba don amfanin mutum ba ko amfani da dabbobi.

Don samun mafi girma solubility, don Allah dumama da bututu a 37 ℃ kuma girgiza shi a cikin ultrasonic wanka na wani lõkaci.Stock bayani za a iya adana a kasa -20 ℃ don da yawa watanni.

4.Further umarnin:

Dolastatin 10 kira
Total kira na Dolastatin 10 (110417-88-4) da aka kammala, ta inganta wani ingantaccen kira na biyu key amino acid da aka gyara, Dil (6) da kuma Dap (11), kuma m stepwise hada guda biyu na biyar amino acid da aka gyara daga C-m Doe .

Yin kira da kimantawa na Dolastatin 10 Analogues da ke riƙe da Hannun Hoto a kan Hannun Amino Acid Yankuna.
Abubuwan da aka kwatanta da sunadarai na al'amuran yanayi na 10 suna da matukar sha'awar ciwon daji saboda abin da suke da shi a cikin vitro da kuma amfani da su kamar yadda aka yi amfani da shi a cikin kwayoyin cutar shan magani (ADCs). Gyara na dolastatin 10 core scaffold ya yafi mayar da hankali a kan gyare-gyare na P1, N-terminus, kuma P5, C-terminus, tare da kadan da hankali ga P2 subunit.

A salula kima, Dolastatin 10 (110417-88-4) ya nuna aiki da wasu mutum cutar sankarar bargo, lymphoma kuma m ƙari cell Lines (kamar OVCAR-3 da NSCLC) tare da IC50 dabi'u jere daga 0.1nM zuwa 10nM. An gwada shi yanzu a gwajin gwaji.


III. Dolaratin 10 (110417-88-4) HCML

Mu ne mai kwakwalwan foda, Fayaccen foda don sayarwa, Raw Aprepitant foda (170729-80-3) hplc ma98% | AASraw R & D masu amsa


IV. Yadda za a saya Dolastatin 10 daga AASraw?

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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