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MMAD (10 Demethyldolast)

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5.00 daga 5 bisa 1 abokin ciniki rating
SKU: 203849-91-6. category:

AASraw yana tare da kira da kuma samar da damar daga gram zuwa tsari na MMAD (Demethyldolastatin 10) (CAS 203849-91-6), a karkashin tsarin CGMP da tsarin kula da inganci mai kyau.

Bugu da ƙari, MMAD an bayar da rahoton cewa za a yi amfani dashi a cikin samar da magungunan miyagun ƙwayoyin cuta (NDCs). A cikin NDCs, an haɗa MMAD tare da anti-5T4 ko anti-Her2 antibody. An nuna cewa NDCs sun nuna kyakkyawan inganci da pharmacokinetics.

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Samfur Description

MMAD (Bidiyon 10 na Demethyldolast)


MMAD (10 Demethyldolastatin) nau'ikan nau'ikan

name: MMAD (10 Demethyldolast)
CAS: 203849-91-6
Kwayoyin Formula: C41H66N6O6S
Girman kwayoyin halitta: 771.06
Shawarwar Melt: N / A
Ajiye Temp: Foda -20 ° C 3 shekaru
4 ° C 2 shekaru
A cikin watanni masu yawa -80 ° C 6
-20 ° C 1 watan
Color: White zuwa kashe-farin (m)


MMAD (10 Demethyldolastatin) (203849-91-6) amfani da shi a yanayin zagaye na steroid

names

Synonyms: Demethyldolastatin 10 (203849-91-6), Monomethylauristatin D; Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide

Gargaɗi akan MMAD (10 Demethyldolastatin)

Ba a cika cikakkiyar samfur don aikace-aikace na likita ba. Don yin bincike kawai

Don samun mafi girma solubility, don Allah dumama da bututu a 37 ℃ kuma girgiza shi a cikin ultrasonic wanka na wani lõkaci.Stock bayani za a iya adana a kasa -20 ℃ don da yawa watanni.

Karin bayani

A cikin Vitro: MMADUM-10-203849) (91-6-2.0) an haɗa ta biyu ta hanyar tsarin tsarin oxime-ligation mai kwakwalwa don samar da magungunan anti-drug-related conjugates (ADCs) tare da wani magungunan magani-to-antibody na ~ 2. Abubuwan da aka haifar da su sun nuna alamun kantin magani, mai yiwuwa a cikin kwayar cytotoxic akan HERXNUMX + ciwon daji. Idan aka kwatanta da ADCs wanda aka tsara ta hanyar cysteine ​​alkylation bayan ragowar interhatin disulfide, an nuna alamun ADCs wadanda ba su da wata al'ada - wadanda aka nuna su sun karu cikin cytotoxicity a cikin vitro

A Vivi: Sakamakon antibody-miyagun ƙwayoyi conjugates (ADCs) nuna cikakken tumo regression a rodents. Har ila yau, suna da bayanin ingantacciyar ilimin toxicology a cikin berayen.


Yadda za'a saya MMAD; saya Demethyldolastatin 10 daga AASraw

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.


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COA

HNMR

Recipes

Karin bayani & amsoshin samfurin