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Alprostadil, (PGE1), Prostaglandin E1

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SKU: 745-65-3. category:

AASraw yana tare da kira da kuma samar da damar daga gram zuwa tsari na Alprostadil, (PGE1), Prostaglandin E1 (745-65-3), ƙarƙashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

Prostaglandin E1 (PGE1), wanda aka fi sani da alprostadil, shi ne abin da ake yi wa prostaglandin ta hanyar halitta wanda ake amfani dashi azaman magani. A cikin jarirai da cututtuka na zuciya, an yi amfani da su ta hanyar jinkirin raƙuwa a cikin wani ɓangaren da za a bude lactus arteriosus har sai an yi aikin tiyata. By allura a cikin azzakari ko sanyawa a cikin urethra, ana amfani da shi don bi da lahani mai tsabta.

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Alprostadil, (PGE1), Prostaglandin E1 bidiyo


Alprostadil, (PGE1), Prostaglandin E1 na ainihi Abubuwa

name: Alprostadil, (PGE1), Prostaglandin E1
CAS: 745-65-3
Kwayoyin Formula: C20H34O5
Girman kwayoyin halitta: 354.48
Shawarwar Melt: 115-116 ° C
Ajiye Temp: 2 ° -8 ° C
Color: White foda


Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) amfani da shi a yanayin zagaye na steroid

names

Alprostadil, (PGE1), Prostaglandin E1 (CAS 745-65-3), wanda ake kira Avastin da Mvasi.

Alprostadil, (PGE1), Prostaglandin E1 Amfani

Bevacizumab ya zo ne a matsayin bayani don gudanar da hankali cikin hankali a cikin wani abu. Bevacizumab takaddamar da likita ko likita a asibitin likita, cibiyar infusion, ko asibiti. An ba Bevacizumab sau ɗaya a kowace makon 2 ko 3.

Ya kamata ya dauki minti 90 don karɓar sakon farko na bevacizumab. Dikita ko likita za su kula da ku a hankali don ganin yadda jikinku ya yi tasiri ga bevacizumab. Idan ba ka da wata matsala mai tsanani idan ka sami kashi na farko na bevacizumab, yawanci zai dauki 30 zuwa 60 minti don ka karbi kowanne daga cikin sauran maganin maganin.

Kiɗa Bevacizumab zai iya haifar da halayen mai tsanani a lokacin jiko na magani. Idan ka fuskanci wani daga cikin wadannan alamun bayyanar, ka gaya wa likitanka nan da nan: wahalar numfashi ko rashin ƙarfi, numfashi, girgizawa, suma, ciwon kai, chestpain, dizziness, jin kunya, flushing, itching, rash, ko hives. Kwararka na iya buƙatar rage jinkirin ka, ko jinkirta ko dakatar da magani idan ka fuskanci wadannan ko wasu tasirin.

Ta yaya Alprostadil, (PGE1), Prostaglandin E1 (745-65-3) ke aiki

Don lura da dysfunction ta erectile (ED), alprostadil ya danganta da tsokoki mai tsabta na corpus cavernosum; Duk da haka, ainihin aikin aikin ba a sani ba. Ya bayyana cewa sakamakon shine saboda kara yawan ƙwayoyin intracellular na AMP cyclic. Alprostadil yayi hulɗar da wasu masu karɓar nau'in halitta wanda ke karfafa motsin adenylate cyclase da kuma tayar da AMP na cyclic intracellular, wanda ke haifar da kunnawa protein kinase kuma ya haifar da hutu mai laushi. Wannan aikin ya bambanta da Papaverine wadda ke hana yin amfani da na'ura mai lamba oxidative phosphorylation ta AMP kuma yana tsangwama tare da allurar alli yayin haɓaka muscle. Alprostadil na iya ƙyale ayyukan da ake yi na norepinephrine ta hanyar hana sakin neuronal na norepinephrine kuma zai iya inganta ayyukan da ba a da magunguna, wadanda ba su da magunguna. Yayinda ake kula da ED, alprostadil yana haifar da tsararraki ta hanyar shakatawa da tsoka da ƙwayar cavernosal da rassan su. Rushewa na cavernosal arteries yana tare tare da ƙara arterial gaggawa gudu da kuma ƙara venous outflow juriya. A sakamakon haka, lacunar sarari yana yadawa kuma jini ya zama wanda ya zama na biyu don matsawa ga magungunan da ake yi a kan maida albuginea. Don samun cikakkiyar tumatir da kuma rigidity, dole ne maida albuginea ya zama cikakke sosai don matsawa cikin raƙuman ruwa ya shiga shi kuma ta haka ne ya kwarara ruwan da ya yi. Wannan tsari kuma ana kiransa shi ne mai haɗin zane-zane na corporal. Alprostadil ba zai shafi tasiri ko haɗari ba.

Yayinda ake kula da lahani na nakasasshen cutar ta jiki, alprostadil yana kula da hanyoyi masu tsauri ta hanyar kwantar da tsokoki na ductus arteriosus. Alprostadil yana da tasiri idan an ba kafin kammala ƙaddamar da ƙirar ductus arteriosus. Gudanarwa na alprostadil don magance cyanotic cututtukan zuciya (ƙuntata jini) yana haifar da karuwa cikin jini da jini da / ko karuwa a haɗuwa tsakanin tsarin jiki da kwakwalwan jini wanda zai haifar da ƙarar lokaci a cikin matsanancin iskar oxygen matsa lamba (PaO2) da kuma iskar oxygen saturation. Maganar cyanotic neonate zuwa farfado da alprostadil ma yana da alaka da nau'in nau'in nau'in wakilci PO2. Mafi girma amsa ya bayyana a cikin waɗanda ba tare da jinkirin low pretreatment PaO2 (<20 torr), narrowing ductus arteriosus, kuma waɗanda suke 4 days old ko ƙarami. Neonates tare da dabi'u na PaO2 na 40 torr ko mafi yawa yawanci yana da ɗan ƙaramin amsa ga alprostadil.

A cikin ƙananan jini tare da ƙuntata jini, tsarin alprostadil zai iya haifar da rigakafi ko gyaran acidmia, ƙara yawan ƙwayar zuciya da ƙara yawan jini, ƙara yawan ƙwayar cuta na mata, ƙara yawan jini da kuma aiki, rage digiri daga sauko zuwa hawan jini aortic jini matsalolin (a cikin ƙuƙwalwa tare da haɗuwa da aorta), da kuma / ko rage raguwa na matsa lamba na motsa jiki don saukowa matsa lamba (a cikin neonates tare da katsewa daga tarin daji). Ba kamar a cikin cyanotic neonates, da inganci na alprostadil a acyanotic neonates ba ya dogara da shekaru ko pretreatment PaO2.

Karin bayani

An yi amfani da Alprostadil (Prostglandin E1) don magance dysfunction (ED) a cikin maza. Amfani da alprostadil a magance ED ya bambanta da dalilin; Sakamakon mayar da martani yana ƙaddamar da marasa lafiya tare da ED saboda ƙwayoyin ƙafa da aka kwatanta da waɗanda ke da ED saboda kwayoyin neurogenic, psychogenic, ko vasculogenic. Ana sayar da siffofin samfurori biyu don magance ED: wani samfuri na ƙwayar cuta (Muse) wanda yayi amfani da pellet wanda aka sanya shi a cikin urethra da allura (Caverject ko Edex) wanda aka sanya shi a cikin corpus cavernosa. Sauran siffofi na sutura kamar gel-gizon da aka yi da kuma tsarin ba da izuwa ga liposomal suna karkashin bincike. A cewar sharuɗɗan kulawar ED, nau'in magunguna na 5 na kwayoyi (PDE5 inhibitor) suna dauke da farfadowa na farko. Hanyoyin magani na biyu sun haɗa da allurar rigakafi da ciwon intra-urethral. Magungunin inuwa mai mahimmanci shine mafi mahimmanci maganin rashin lafiya ga ED, tare da amsawar da za a iya gani da kuma ci gaba. Duk da haka, yana da haɗari da kuma caries sananne gefen-effects ciki har da priapism da penile fibrosis. Bayanan FDA sune kamar haka: Kashi a cikin Yuli 1995, MUSE a watan Oktoba 1996, da Edex a Yuni 1997.

Alprostadil da sauran prostaglandins a cikin jerin E shine suna a halin yanzu a cikin ƙwayar placenta da ductus arteriosus na tayin. Hanyoyin E-type prostaglandins sunyi amfani da shi ta hanyar shakatawa na kwantar da hanzari. Sauran maganganun maganin maganin magungunan magani sun hada da haɓaka a cikin ƙwayar zuciya, dilagewa na tsarin tsarin jiki da kuma kayan kwakwalwa, dullin ductus arteriosus, hana ƙin plaquettes, shakatawa na muscle bronchial, ƙara yawan jini, da kuma jinkirta lokacin ɓata. Ana amfani da alprostadil mai ɓarna a cikin ƙuƙwalwa tare da ƙuntatawa daga hagu na ventricular hagu ko hagu don kula da ɓangaren ductus arteriosus har zuwa lokacin gyarawa ko aikin tiyata. Alprostadil ya fi tasiri a cikin wadanda ba tare da jinkirta jini ba a cikin jini PO2 da kuma wadanda ke da shekaru 4 ko kasa. A cikin kwanakin da suka wuce shekarun 4, akwai ƙananan ƙwayar muscle mai laushi ta hanyar canjin canji na postnatal a cikin bango na ductus arteriosus. Rashin aikin alprostadil mai tsanani yana buƙatar saka idanu na numfashi a lokacin gwamnati domin ana iya gina apnea a cikin 10-12% na wadanda ba su sani ba. Alprostadil an amince da FDA a cikin marasa lafiyar yara a matsayin matashi kamar yadda ba a sani ba. FDA ta amince da Fediatric na 1981.


Yadda za a sayi Alprostadil, (PGE1), Prostaglandin E1 daga AASraw

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.


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