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Canrenone foda (976-71-6)

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SKU: 976-71-6. category:

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa umurnin taro na Canrenone foda (976-71-6), a karkashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

Canrenone foda an gudanar da shi a cikin asali na 2 × 82 MG da 2 × 164 MG kowace rana a kan kwanakin 10 zuwa marasa lafiya na ciwon sukari marasa lafiya na zuciya, da hanta ko koda. Agreosterone excretion da plasma aldosterone ya karu kawai dan kadan a lokacin dukkan gwamnatoci.

Samfur Description

Canrenone foda video


Canrenone foda ainihin Maƙallan

name: Canrenone foda
CAS: 4642-95-9
Kwayoyin Formula: C18H20O2
Girman kwayoyin halitta: 258.36
Shawarwar Melt: 138-141 ℃
Ajiye Temp: Room Zazzabi
Color: White ko haske rawaya Crystalline foda


Canrenone foda sakewa

names

COMMON BRAND (S): Canrenone foda
SANAR SANTA (S): Contaren, Luvion, Phanurane, Spiroletan

Canrenone foda Amfani

Matakan plasma na Canrenone foda da 'ƙa'idodi da yawa' bayan an samar da hydrolysis a cikin matasan matasa da tsofaffi bayan sharuɗɗun spironolactone. Bayan da aka fara amfani da shi a ranar 1, matakan plasma na Canrenone raw foda da 'total metabolites' sun fi girma a cikin matasa fiye da tsofaffi tsofaffi, kuma an sami gagarumin bambance-bambancen tsakanin kungiyoyi biyu a AUC na Canrenone foda da "duka metabolites '. Duk da haka, waɗannan bambance-bambance tsakanin kungiyoyi biyu sun ragu bayan da aka yi amfani da su a ranar 8, da kuma matsakaicin matakin plasma na ƙananan Canrenone da kuma yawan '' metabolites '' sun kasance mafi girma a cikin batutuwa tsofaffi. Rashin haɗuwa na Canrenone foda da 'dukkanin metabolites' sun kasance mafi girma a cikin tsofaffi fiye da matasa. Dukkanin Canrenone raw foda da kuma canrenoic acid sun kasance suna da alaka da sunadaran plasma, amma babu bambancin dake tsakanin kungiyoyi biyu a cikin furotin. Bambance-bambance da aka kiyasta a cikin matakan plasma bayan jinsin aure da yawa tsakanin matasa da tsofaffin batutuwa na iya haifar da wasu dalilai masu yawa irin su matsin lamba a cikin metabolism tare da shekaru; rashin ciwo ta hanyar iyaye na iyaye; da / ko sauya girma na rarraba miyagun ƙwayoyi.

Menene sashi na Canrenone foda

Yawanci, a mafi yawan lokuta, 50-200 MG kowace rana a matsayin guda ɗaya ko a cikin hukumomi masu yawa ya isa.
A lokuta mafi tsanani, za a iya ƙaddamar da samfurin na farko zuwa 300MM ko fiye, to, an gyara kashi a cikin amsawar asibiti da kuma ƙididdigar labarun.

Ta yaya Canrenone foda aiki

Hanyar HPLC ta hanyar ci gaba ta hanyar samfurori da aka yi a kan TQ4 Quantum Discovery sau uku ma'aunin digiri na quadrupole tare da tsarin AAC CTC HPLC autosampler. A karkashin kyakkyawan electrospray ionization babban ion da aka gano shi ne kwayoyin sunadarai (M + H) + m / z 341 na Canrenone foda. An yi amfani da Alfaxalone (ma'anar da aka yi amfani dashi m / z 333; 1 μg) a matsayin misali na ciki. A yayin da aka fara aiki, manyan ions masu rarraba sun kasance m / z 107.1 da 91.1 don Canrenone raw foda da m / z 297.3 da 315.3 don alfaxalone. An yi amfani da ions mai rarrabuwa a matsayin masu mahimmanci da ƙirar cancanta don ƙara bayani game da gwaji. An rarraba rabuwa mafi kyau na steroid din ta hanyar amfani da ammonium acetate (5 mM) / methanol a (60: 40, 0.3 ml / min) a kan wani Rigon C18 T3 Atlantis HPLC (3 μm; 100 × 2.1 mm) a 25 ° C. An yi wani digiri daga 40 zuwa 90% methanol, tare da lokacin tafiyar 8 gaba daya.

Tabbatar da sigogi na mahimmanci an yi ta ta amfani da intra- da inter-assay replicates. Maganar da aka samo daga Canrenone foda da alfaxalone (106.2%) (DND) 9.5%) da 102.2% (RSD 4.7%)) sun samu bayan kamuwa da ruwa-ruwa daga kawai 25 μl plasma tare da acetate ethyl (1: 10). Ƙimar da aka gano shi ne 5 ng / ml kuma ƙananan ƙididdigar sune 15 ng / ml. Wannan gwajin ya kasance linzamin (r = 0.9936) a kan iyakoki (5 ng / ml zuwa 5 μg / ml). Wannan gwaji ya dace da kimantawa na Canrenone raw foda a cikin rukuni na marasa lafiya wanda ya karbi nau'in 400 na MV, wanda aka samu a cikin ƙwayar 5-45 μmol / l.

Amfanin Canrenone foda

Canrenone foda shi ne babban aikin da ake amfani da su na spironolactone. Ta hanyar nazarin tsarin, yana aiki tare da aldosterone ta hanyar kawar da shi daga tashoshin masu karɓa a matakin ɓangaren ƙananan ƙwararru na ɗakunan ƙirar da kuma ɗakin tattarawa; wannan yana haifar da karuwa a diuresis da natriuresis da rage a kaliureis. Idan aka kwatanta da spironolactone yana da amfani da lokacin lalata. Kamar spironolactone, duk da haka, ba shi da wani aiki a cikin batutuwa na kankara ko kuma a cikin al'amuran al'ada tare da ƙananan aldosterone marasa tushe.
Bayan gwargwadon maganganu, za a iya tunawa da ƙananan furotin na Canrenone, kai tsaye ga yawan ƙwayar plasma a cikin sa'o'i biyu na farko. Rabin rabin rayuwa game da 18 hours kuma, ba kamar spironolactone, an cire shi ba tare da canzawa ba, a cikin 72 hours, tare da fitsari da kuma faeces a daidai adadin.
Ana nuna furotin na canrenone a cikin yanayin asibiti inda yawancin aldosterone ya samar da ruwa da sodium da karuwar dijar. Yana da amfani wajen lura da ascites a cikin cirrhosis na hanta, koda kuwa ana cigaba da sashi don amsawa a cikin kowane hali.

Canrenone foda

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mai girma zai iya aikawa a cikin kwanakin 3 aiki bayan biya.

Canrenone raw foda Marketing

Da za a bayar da shi a nan gaba.

Canrenone raw foda dubawa

Canrenone raw foda ne mai aiki na rayuwa na spironolactone, canrenoic acid, da potassium canrenoate, kuma ana daukar su zama alhakin abubuwan da suka shafi. An samo asusu don kimanin 10 zuwa 25% na tasirin potassium na spironolactone, yayin da wani abin da ake amfani da shi, 7a-thiomethylspironolactone (7A-TMS), yana da asusun na 80% na magungunan potassium da aka rage ta magani.

Canrenone foda yana da rahotanni mafi girma a matsayin antimineralocorticoid zumunta da spironolactone, amma yana da ƙasa da rashin karfi da kuma tasiri a matsayin antiandrogen. Hakazalika ga spironolactone, Canrenone raw foda ya hana ingancin steroidogenic irin su 11β-hydroxylase, ƙananan zafin kafa na cholesterol, sarkar 17a-hydroxylase, 17,20-lyase, da kuma 21-hydroxylase, amma kuma a sake, ba shi da iyakacin yin hakan.


Yadda za a saya Canrenone foda daga AASraw

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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COA

HNMR

Recipes

Canrenone raw foda Recipes

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

Karin bayani & amsoshin samfurin