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MMAF (Hydrochloride) (1415246-68-2)

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5.00 daga 5 bisa 1 abokin ciniki rating
SKU: 1415246-68-2. category:

AASraw yana tare da kira da kuma samar da damar daga gram zuwa tsari na MMAF (Hydrochloride) (CAS 1415246-68-2), a karkashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

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Samfur Description

MMAF (Hydrochloride) bidiyo


MMAF (Hydrochloride) ma'auni na asali

name: MMAF (Hydrochloride)
CAS: 1415246-68-2
Kwayoyin Formula: C39H66ClN5O8
Girman kwayoyin halitta: 768.42
Shawarwar Melt: 314.3 ° C a 760 mmHg (An Shari)
Ajiye Temp: Foda -20 ° C 3 shekaru
4 ° C 2 shekaru
A cikin watanni masu yawa -80 ° C 6
-20 ° C 1 watan
Color: White crystalline foda


MMAF (Hydrochloride) amfani da shi a yanayin zagaye na steroid

names

MMAF (Hydrochloride) (1415246-68-2) kuma kira Monomethylauristatin F Hydrochloride, MMAF HCL

MMAF (Hydrochloride) Amfani

Masanin kimiyya na likita yana da yawa a kan MMAF, a nan kasa akwai wasu bayanai don tunani:
A Vitro: MMAF yana nuna cytotoxicity a cikin wani sashen layi. Ayyukan IC50 na Karpas 299, H3396, 786-O da Caki-1 sune 119, 105, 257, da 200 nM, daidai da haka. MMAF da aka ƙaddara yana da karfi fiye da miyagun ƙwayoyi kyauta, da kuma cAC10 conjugates na MMAF nuna ayyukan. A kan mahimmanci, CAC10-L1-MMAF4 yana da ƙananan fiye da 2200-ninka mafi girma fiye da kyautar MMAF kuma yana aiki a kan dukan CD30-positive cell lines gwada

A Vivo: Matsakaicin matsakaicin magani a cikin mice na MMAF (1415246-68-2) (> 16 mg / kg) yana da yawa fiye da MMAE (1 mg / kg). CAC10-L1-MMAF4 yana da MTD na 50 mg / kg a cikin ƙananan yara da 15 mg / kg a cikin berayen. CAC10-L4-MMAF4 ADC daidai ya zama mai guba, yana da MTDs a cikin mice da berayen na> 150 mg / kg da 90 mg / kg a cikin berayen, bi da bi

Gargaɗi kan MMAF (Hydrochloride)

Don bincike da aka yi amfani kawai

Karin bayani

An rubuta cewa F Hcl (MMAF Hcl) na Monomethylauristatin wani wakilin antitubulin ne wanda ke hana rikici ta cell ta hanyar hanawa polymerization na tubulin; kuma aikin da aka fi sani da thecytotoxic ya fi kasa da MMAE; kuma yana da kwayar cutar cytotoxin antibody.

Sanya Sanya
Ana sa sẹẹli tare da jigilar salula na kwayoyin gwaje-gwaje da kwanakin 4-6 da aka ƙaddara dangane da layin salula. Bincike na girma salon salula da kuma rage bayanai don samar da dabi'un IC50 an yi ta amfani da ƙaddamar da yaduwar launin ruwan ƙyalƙyali Alamar
MCE ba ta tabbatar da gaskiyar waɗannan hanyoyin ba. Su ne kawai don tunani kawai.

Gudanar da dabbobi
Mice: binciken ya nuna cewa lokacin da ƙananan hanyoyi na Karpas 299 ya kai 300 mm3, dabbobin guda uku suna karɓar allurar 10 mg antibody bangaren / kg nauyin jiki na ko dai CAC10-L1-MMAF4 ko CBR96-L1-MMAF (1415246-68-2 ) 4 cikin intravenously. Za a cire tumors a wuri mafi kyau da zazzabi mai zafin jiki, kuma sassan jikin jiki na 5 μm-na bakin ciki suna stained ta yin amfani da kimanin kimantawa na immunohistochemistry.
MCE ba ta tabbatar da gaskiyar waɗannan hanyoyin ba. Su ne kawai don tunani kawai.


Yadda za'a saya MMAF; saya Hydrochloride daga AASraw

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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