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Sunifiram (DM235) foda

Rating:
5.00 daga 5 bisa 1 abokin ciniki rating
SKU: 314728-85-3. category:

AASraw yana tare da kira da kuma samar da damar daga gram zuwa tsari na yawan Sunifiram (DM235) foda (314728-85-3), a ƙarƙashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

Samfur Description

Sunifiram (DM235) foda


Sunifiram (DM235) ƴan Maɗaukaki

name: Sunifiram (DM235) foda
CAS: 314728-85-3
Kwayoyin Formula: C15H13F2NO2S
Girman kwayoyin halitta: 309.33
Shawarwar Melt: 57-58 ° C
Ajiye Temp: Store a dakin da zazzabi ko mai sanyaya
Color: White ko kashe-farin foda


Sunifiram (DM235) foda a cikin kwakwalwa ta amfani

names

Sunifiram foda, DM235 foda yana da sunan kasuwanci kamar BisfluoroModafinil, Flmodafinil.

DM235 foda Amfani

DM235 foda shi ne wani littafi, mai mahimmanci maras kyau da kuma ampaccine mai kama da AMPAkine tare da sakamakon haɓakawa a cikin ƙwayoyin dabba.

Sunifiram foda ne mai piperazine wadda ke da wasu kamanni irin su piracetam. An kirkiro Piracetam don cututtukan neurodegenerative kamar cutar Alzheimer, kuma sunadarai Sunifiram da aka sani don bunkasa aikin haɓaka a cikin wasu gwaje-gwaje na hali. A cikin mai karɓa mai ɗaukar karatu, Sunifiram raw foda ba ya nuna affincin ga mafi yawan masu karɓar raƙuman ruwa ko tashoshi (babu wata dangantaka a 1MM don serotoninergic, dopaminergic, muscarinic, nicotinic, adrenergic, glutamatergic, histaminergic, opioid, ko GABAergic receptors), duk da haka yana inganta saki acetylcholine daga girasar cizon sauro, mai yiwuwa ta hanyar daidaitaccen amsawar mai karɓa na AMPA.

Sunifiram foda yana hana amnesia haifar da scopolamine, bayan ip da kuma shugabancin dare, a cikin linzamin kwamfuta na gwajin gwagwarmaya tare da ƙananan tasiri na 0.01 mg / kg po. Abubuwan da ake amfani da sunadarai Sunifiram sune kama da abin da aka yi amfani da kwayoyi irin su piracetam (30 mg / kg ip), aniracetam (100 mg / kg po) da kuma rolipram (30 mg / kg po), amma tare da nauyin 1,000 - 10,000 sauƙi mafi girma.

Gargaɗi kan tasirin sakamako na DM235

Sunifiram foda (DM-235) wani nau'in bincike ne wanda ke da nasaba da amnesiac a nazarin dabba tare da matukar girma fiye da piracetam. Sunifiram raw foda shine simplification kwayoyin unifiram. Bisa ga nazarin a cikin bitro da na dabba, yana nuna cewa sunadaran Sunifiram suna aiki ta hanyar aiki AMPA-receptor.

Sunifiram raw powder yana aiki ta hanyar kunna masu sauraron AMPA; wato, masu karɓa da ke da alhakin sabuntawa na synaptic watsawa a cikin tsarin kulawa na tsakiya. Ma'aikatanta kuma suna ƙaruwa da phosphorylation na AMPAR da NMDAR ta hanyar haɓaka kin kinase, wanda hakan zai inganta halayyar lokaci mai tsawo - wato, haɓakawa a sigina tsakanin na'urori guda biyu da aka haifar da ƙarfin lokaci.

Harkatarwar kin kin da Shafin Sunifiram ke shafar yana inganta lahani. Bugu da ƙari, Sunifiram raw powder aiki a cikin cerebral cortex na batutuwa gwaji ta hanyar taimakawa a cikin saki acetylcholine, kwayoyin halitta da cewa aiki a matsayin neurotransmitter a cikin wani taro na daban-daban kwayoyin. Wadannan hanyoyin sarrafawa suna taimakawa Sunifiram foda don yin amfani da kayan amsiac.

Karin bayani

Sunifiram foda ma yana iya hana amnesia da aka haɓaka ta mai kwakwalwa mai kyamara mecamylamine, GABAB agonist baclofen, α2 agonist clonidine da kuma ambagonist AMAC na NBQX a cikin gwaji na gujewa.

A cikin yarin Morris gwajin ruwa, gwajin scopolamine ya hana rage latency a cikin tantancewa da kuma riƙe gwaji na gwaji. Sunifiram raw foda, an gudanar 20 min kafin kowace horon horo, yana iya hana ƙwayar ƙwaƙwalwar ajiyar scopolamine a 0.1 mg / kg ip

Sunifiram foda yana samar da ƙananan ƙwayoyin cuta da ƙwayoyin cuta ba tare da wani gyare-gyaren da ake gani ba a cikin babban hali na ƙwayoyi ko berayen, kuma a cikin 0.1 mg / kg ip, Sunifiram foda ya rage tsawon tsinkayen da aka haifar da pentobarbital a cikin mice ba tare da gyaggyara lokacin hawan hypnoosis ba. Bugu da ƙari, mice da aka yi da Sunifiram raw foda riƙe haɗin kai a cikin gwajin rotarod. Halin motsa jiki marar lahani, wanda kayan aikin Animex yayi nazari, da kuma fasalin bincike, wanda aka gwada ta hanyar gwaji, ya kasance al'ada bayan gwamnatin Sunifiram.

Sunifiram raw foda yana yada kyakyawan ƙwayar cuta a cikin ƙwayar motsa jiki na ratsan motsi. Kamar yadda gwaje-gwaje na microdialysis ya nuna, Sunifiram foda yana iya ƙara sakin ACh a kashi na 0.01 MG / kg, tare da iko mafi girma fiye da Unifiram.

Bayyana nau'in sopocampal rat na 100 μM NMDA ya haifar da karuwar [3H] NE (48). Sakamakon NMDA an hana shi ta musamman daga 100 μM kynurenic acid (KYNA). Bugu da ƙari na ƙwayoyin nanomolar sunadarai na Sunifiram sunadarai sun canza KYNA antagonism. Sakamakon Sunifiram foda shine maida hankali (EC50 0.1 μM) kuma kusan cikakke a 1 μM.

Za'a iya tantance shigarwar masu sauraron AMPA ta hanyar aikace-aikacen mai karɓar ragamar mai karɓa ta AMPA mai zaman kansa NBQX. Idan aka yi amfani da shi a 5 μM, NBQX ya hana watsi na 3H NE wanda aka ambata ta AMPA (100 μM), amma ba XITUMX μM NMDA ba da aka saki daga wasu nau'in hippocampal rat (100). NBQX, yana aiki a kan kansa, ya karyata ƙwayar Sunifiram rwa ta yunkurin KYNA da aka kaddamar da shi daga NMDA, wanda ya ba da shawarar shigar da masu sauraron AMPA a sakamakon sunadarai Sunifiram.

Abin sha'awa, a ƙarƙashin yanayin ƙananan, sunadarai sunadarai Sunifiram sun kara PKCa (Ser-657) da kuma Src iyali (Tyr-416) tare da wannan nau'i-nau'i-nau'i-nau'i-nau'i-nau'i-nau'i-nau'i-nau'i kamar yadda yake na LTP, mai suna 10 nM. Ƙara yawan phosphorylation na PKCa (Ser-657) da kuma Src (Tyr-416) wanda Sunifiram foda ya jawo ya hana shi ta hanyar 7-ClKN magani. Ƙara inganta ta LTP ta Sunifiram raw foda an haramta shi ta hanyar PP2, mai hana dangi na Src.

A ƙarshe, lokacin da aka yi amfani da babban ƙwayar glycine (300 lM), magunguna Sunifiram sun kasa samun damar LTP a cikin yankin CA1.

A haɗuwa, shaidun da ke sama sun nuna cewa sunadarai Sunifiram mai tsabta yana karfafa wurin glycin-binding na NMDAR tare da kunnawa PKCa ta hanyar Src kinase. Ƙara inganta ayyukan PKCa yana haifar da haɓakawa na LTP hippocampal ta hanyar kunnawa CaMKII.

Sunifiram (DM235) Rashin Foda

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mafi girma (A cikin 1kg) za'a iya aikawa cikin 3 kwanakin aiki bayan biya.

DM235 foda Marketing

Da za a bayar da shi a nan gaba.


Yadda zaka saya DM235 foda: saya Sunifiram foda daga AASraw

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


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COA

HNMR

Sunifiram (DM235) foda (314728-85-3) hplc≥98% | Kamfanonin AASraw HNMR

Recipes

Sunifiram (DM235) Sauke-girke:

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

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