NMN foda - Maƙerin Masana'anta
AASraw yana samar da NMN da NRC foda a cikin girma!

-Nicotinamide Mononucleotide

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AASraw yana da cancanta don samar da samfuran tsufa-NMN Foda a cikin yawa tare da tsarin CGMP da tsarin kula da ƙimar inganci. Matsakaicin matsakaicinmu na wata yana iya kaiwa 1500kg. Barka da zuwa tuntube mu don ƙarin bayanin siye:
Matsayi: A cikin kaya

Ungiyoyin fakiti: 1kg / jaka, 25kg / drum

Samfur Description

Abubuwa Na Asali

Product Name β-Nicotinamide Mononucleotide (NMN)
CAS Number 1094-61-7
kwayoyin Formula C11H15N2O8P
Formula Weight 334.22
nufin abu ɗaya ne NMN;

-D-NMN;

BETA-NMN;

beta-D-NMN;

NMN foda;

NMN zwitterion;

NICOTINAMIDE RIBOTIDE;

Nicotinamide nucleotide;

Nicotimide mononucleotide.

Appearance White foda
Ajiye da kulawa 2-8 ° C a bushe wuri

Maballin Maɓalli:

AD NAD + yana da mahimmin coenzyme da ake buƙata don rayuwa da ayyukan salula.

Matakan NAD +, musamman siffar NAD +, a zahiri yana raguwa da shekaru a cikin yawancin kyallen takarda.

♣ Jiki yana ƙirƙirar NMN azaman matsakaiciyar mataki ko “ƙaddara” ga NAD +. A sauƙaƙe: mafi girman matakan NMN yana nufin matakan NAD + mafi girma.

Abubuwan da aka lura: A waɗannan labaran, Anyi amfani da NMN maimakon β-Nicotinamide Mononucleotide (NMN)


 

Bayanin NMN- NAD + & NMN

NAD + fili ne na musamman, ana ci gaba da yin shi a jikin mu kuma yawancin enzymes masu amfani suna amfani dashi don haɓaka ingantaccen aikin salula. Koyaya, tunda NAD + yayi amfani dashi wajen samar da waɗannan tsarin enzyme, zamu fara shiga raunin NAD + a wurare daban-daban a rayuwarmu, tare da ƙaruwa yayin da muke tsufa. Tunda waɗannan enzymes masu amfani da NAD + suna da mahimmiyar rawa wajen kiyaye kuzarin salula, da haɓaka lafiyar salula, raguwar NAD + na iya zama babbar illa ga lafiyarmu gaba ɗaya.

Saboda wannan, an fara bincike mai yawa don inganta matakan NAD + a cikin jiki. Ka'idar da ke bayan inganta matakan NAD + ita ce cewa zai sami babban taimako ga yawancin ayyuka masu mahimmanci na jiki, don haka zai iya taimakawa inganta tsawon rai. Mafi mahimmanci duk da haka, ingantattun matakan NAD +, ya kamata ba kawai inganta tsawon rai ba, yana iya kuma taimakawa inganta ingantaccen rayuwa yayin da muke tsufa!

Don haka ta yaya za mu ɗaukaka matakan NAD +? Wannan yana da kyau. Koyaya, binciken da aka yi kwanan nan ya gano wani fili na musamman da ake kira Nicotinamide Mononucleotide (NMN), wanda jiki zai iya amfani dashi azaman ingantaccen tsari ga NAD +. A ka'ida, wannan yana nufin NMN na iya inganta rayuwa mai kyau da lafiya!

Koyaya, NMN ba kawai ingantaccen tsawon rayuwa bane mai haɓaka kari. A zahiri, NMN kyauta ce mai ban sha'awa ga matasa da tsofaffi, saboda tana da tasiri komai tsufa. Matasa da tsofaffi duka suna buƙatar matakan NAD + masu girma don jikinsu da tunaninsu don yin aiki mafi girma. Matsayi mafi girma na matakan NAD +, ƙimar ƙarfin salula za ku sami, kuma mafi kyawun jikinku da tunaninku za su iya aiki a cikin mawuyacin yanayi. Bari mu kasance masu gaskiya, wa ba zai iya yin amfani da ɗan ƙaramin abu a cikin wannan duniya mai sauri da sauri ba? Don haka, idan kuna son cajin ƙwayoyinku, kuma kuna sha'awar abin da jikinku da tunaninku za su iya cimma tare da ƙarin ƙarin NAD + yana zagayawa, to, za mu ƙarfafa ku da ku ci gaba da karantawa ta wannan ingantaccen blog ɗin da aka tsara don taimaka muku samun mafi daga cikin karin NMN!

 

Menene NMN?

NMN (Nicotinamide Mononucleotide) na dangin nucleotides ne, kwayoyin da ake samu a yawancin abincin da muke ci. Kamar yadda yake tare da dukkanin nucleotides, NMN ya ƙunshi sassa 3: tushen nitrogenous, sukari, da ƙungiyar phosphate.

Duk da yake ana amfani da yawancin nucleotides don gina DNA, ana amfani da NMN don yin adonine dinucleotide adonin (NAD +) na nicotinamide (NAD +) da daidaitawar kuzari mai kyau. Jiki yana ƙirƙirar NMN a matsayin tsaka-tsakin matsakaici ko “ƙaddara” ga NAD +. A sauƙaƙe: mafi girman matakan NMN yana nufin matakan NAD + mafi girma.

NAD + yana ƙara yawan kuɗaɗen kuzarin jiki (ATP), yana daidaita yanayin juzu'i, kuma yana ba da ɗaruruwan halayen enzymatic - yawancinsu suna jinkirta tsufa. Matakan NAD +, musamman nau'ikan NAD +, a zahiri yana raguwa da shekaru a cikin yawancin kyallen takarda.

 

Ta yaya NMN ke Aiki? / Me yasa ake Bukatar ƙarin NMN?

NR da NMN suna da fa'ida duka saboda suna haɓaka matakan NAD +, wanda ke raguwa tare da shekaru. NAD + yana da mahimmanci ga tasirin salula, juya abubuwan gina jiki zuwa makamashi na salula, kuma hakan yana kunna sirtuins, jerin sunadaran da ke tsara lafiyar salula. Dukanmu muna samun NAD + a cikin jikinmu albarkacin abincinmu, ta hanyar cin abinci tare da abubuwan NAD + masu ƙima a cikinsu. Duk da yake ana iya samun NR da NMN a cikin adadi mai yawa a cikin abinci daban-daban, kodayake, mutum baya iya cin wadataccen abu don haɓaka matakan NAD +. A sakamakon haka, kari tare da NAD + precursor na iya taimakawa rage ragin.

 

Amfanin NMN

  • NMN na haɓaka samar da makamashi a cikin ƙwayoyin tsufa:

Kwayoyin suna ɗauka da sarrafa mai don ƙarfafa ayyukansu. Yayin da kuka tsufa sai suka rasa wannan damar, tilasta su cikin yanayin da aka sani da tsufa na salula ko tsufa wanda ya zo tare da wasu abubuwa masu illa. zuwa kuzarin tantanin halitta.Wannan yana nufin cewa haɓaka tare da NMN yana ba wa ƙwayoyinku hanzari mafi sauri don mai da haɓaka haɓakar tantanin halitta da haɓaka.

 

  • NMN tana taimakawa wajen yaƙar cututtukan rayuwa:

Yayin da kuka tsufa, yanayi kamar ciwon sukari, kiba, dyslipidemia, da cututtukan hanta mai haɗari (NAFLD) sun zama gama gari. Ana haifar da su ta ragewar matakan NAD +. NMN tana aiki ta hanyar salvage don haɓaka matakan NAD + don haka inganta waɗannan da sauran cututtukan rayuwa.

 

  • NMN na sake kunna rawan jini:

Yayinda jiki yake tsufa, lamba da ayyukan ƙwayoyin endothelial (ECs) masu haɗa jijiyoyin jini sun ragu.NAD + magabata kamar NMN da nicotinamide riboside (NR) da ke aiki ta hanyar Sirtuin Pathway, na iya taimakawa dawo da ƙarfin ƙwayoyin endothelial don samar da sabon jini tasoshin.

 

  • NMN tana hana karɓar nauyi mai alaƙa da shekaru:

Yayinda mutane suka tsufa, suna kara nauyi. A cikin nazarin na 2016, an gano cewa batutuwa da aka ba NMN sun ga yawan ƙibarsu yana ƙaruwa kuma siraran ƙaruwa yana ƙaruwa. Ta hanyar haɓakawa tare da NMN, zaku iya rasa nauyi kuma ku gina tsoka - hanyoyi biyu masu ƙarfi don haɓaka lafiyar tsoka da kallo da jin ƙuruciya!

 

  • NMN na ƙarfafa haɓaka makamashi:

Ta hanyar yin sulhu da kira na NAD +, NMN yana taimakawa cikin rarraba abubuwan gina jiki cikin kuzari, samar da mahimman ayyukan ƙwayoyin salula da rage stressarfin ƙwayoyin cuta. Waɗannan hanyoyin nazarin halittu suna jinkiri kuma suna iya dakatar da tsarin tsufa. NMN ba kawai yana ƙarfafa kuzarin ku ba amma yana taimakawa wajen gyara ƙwayoyin ku!

 

NMN Tsaro da Tasirin Gefen

NMN ana daukarta mai lafiya a cikin dabbobi, kuma sakamakon yana da kwatankwacin yadda gwajin ɗan adam ya fara. Wannan kwayar halitta ana ɗaukarta mai haɗari kuma ba mai guba ba, koda a cikin manyan ƙwayoyi a cikin beraye kuma a cikin binciken ɗan adam. Gudanar da baki na tsawon shekara (shekara ɗaya) a cikin beraye ba shi da illoli masu guba. An gama gwajin gwaji na farko a cikin mutane kuma shaidun suna tallafawa ra'ayin cewa ba mai guba ba ne a cikin allurai guda ɗaya.

Kodayake wani binciken da aka yi game da maza 'yan Japan da aka buga a watan Nuwamba na 2019 ya lura cewa batutuwa sun haɓaka yawan bilirubin a cikin jininsu bayan gwamnatin NMN, waɗannan matakan sun kasance cikin yanayin al'ada. Karatu na gaba ya kamata su mai da hankali kan aminci na dogon lokaci da ingancin amfani. NMN ba shi da alaƙa da kowane sanannen sakamako masu illa.

 

NMN azaman ADarin NAD +-Mashahuri sosai

Concentididdigar intracellular na NAD + raguwa daga tsufa kamar yadda ayyukan salula na yau da kullun suka lalata kayan NAD + akan lokaci. Ana tunanin za a dawo da matakan lafiya na NAD + ta hanyar haɓakawa tare da ƙaddara NAD +. Dangane da bincike, magabata kamar su NMN da nicotinamide riboside (NR) ana kallon su azaman kayan aikin NAD +, ƙara haɓaka NAD +. David Sinclair, mai binciken NAD + daga Harvard, ya ce, “Ciyar ko sarrafa NAD + kai tsaye ga ƙwayoyin halitta ba zaɓi ne mai amfani ba. Kwayar NAD + ba za ta iya ƙetare membran ƙwayoyin salula cikin sauri ba don shigar da ƙwayoyin halitta, sabili da haka ba zai sami tasiri mai tasiri ba game da metabolism. Madadin haka, dole ne a yi amfani da ƙwayoyin cuta na farko zuwa NAD + don ƙara matakan da ba za a iya samu na NAD + ba. ” Wannan yana nufin ba za a iya amfani da NAD + azaman ƙarin kai tsaye ba, saboda ba sa saurin ɗaukarta. NAD + precursors sun fi saurin samun nutsuwa fiye da NAD + kuma sun fi inganci kari.

 

Dole ne ku sani Kafin Sayi NMN Foda akan layi

 

Structure Tsarin mara ƙarfi

Generationarnin farko na NMN tare da ƙarancin ƙarfi ba shi da kyakkyawan ruwa. Ingantaccen fasalin AASraw na NMN zai rage farashin masana'antun ta hanyar mafi kyawun kwararar foda wanda ke haifar da haɓaka ƙarfin samarwa saboda zai zama da sauƙi a bi ta cikin injunan. Abin da ya fi haka, wannan sigar zai haifar da daidaitaccen sashi na kawunansu kamar yadda ƙirar keɓaɓɓiyar siga ke da wuya a haɗe gaba ɗaya. Aƙarshe, ƙarancin NMN foda da aka matse cikin nau'in kwamfutar hannu zai iya warwatse sauƙi yayin wucewa.

Abokan ciniki da yawa suna ƙoƙari su warware wannan ta ƙarin ƙarin ƙari amma hakan yana haifar da manyan allunan, wanda ba shine mafi kyau ga masu amfani a cikin tsofaffin waɗanda aka ƙaddara ba. Don haka, ƙananan ƙarfin NMN kawai ya dace da samfurin samfurin foda.

 

▲ Ruwan da aka Cutar da sinadarin NMN.

Kasuwa ta cika da ambaliyar NMN ta lalata da lalata. Tunda NMN ta shiga kasuwa a shekarar da ta gabata yawancin sababbin samfuran NMN sun bayyana ɗayan bayan ɗaya. Yana da matukar wahala ga masana'antun da kwastomominmu su fada ainihin kayan mai inganci daga kayan jabu da masu karancin tsarkin da aka siyar akan yanar gizo.

Wasu samfuran NMN da aka siyar suna da ƙasa da tsarki 80%. Abokan ciniki da abokan ciniki ba su san abin da filler ko gurɓatuwa suke a cikin sauran 20% na samfurin ba.

Mun gano cewa yawancin masu samar da NMN suna sayar da nicotinamide (talakawan bitamin B3) ko nicotinamide riboside maimakon NMN. Koda mafi yawan masu samarda suna ƙara gari don narke NMN da yaudarar abokan cinikin su. Waɗannan samfuran galibi suna da arha amma kuma ba tare da wani tasiri mai amfani ba.

 

▲ Rashin aminci da ingantaccen bayanai.

NMN ya zama mafi mashahuri a cikin Amurka, Turai, Japan da China, da sauransu, amma yawancin aminci da ingantattun bayanai har yanzu suna rasa. Mutane da yawa har yanzu basu yarda da wannan samfurin ba, don haka kasuwar NMN koyaushe tana da iyaka. A zahiri NMN asalinsa yana cikin jikin mutum kuma wasu kayan lambu kamar broccoli, don haka bashi da wata matsala ta tsaro. Amma lokaci yayi da za a kara tabbatar da ingancin sa.

 

[reference]

[1] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. (Mayu 2018). "+ Ragewa" Cell metabolism. 27 (5): 1081-1095.e10. Doi: 10.1016 / j.cmet.2018.03.016. PMC 5935140. PMID 29719225.

[2] Stipp D (Maris 11, 2015). "Beyond Resveratrol: Anti-tsufa NAD Fad". Hanyoyin sadarwar Blog na Amurka.

[3] Cambronne XA, Kraus WL (Oktoba 2020). “+ Haɗakarwa da Ayyuka a cikin swayoyin Mammalian”. Yanayi na Kimiyyar Biochemical. 45 (10): 858-873. Doi: 10.1016 / j.tibs.2020.05.010. PMC 7502477. PMID 32595066.

[4] Bogan KL, Brenner C (2008). "Nicotinic acid, nicotinamide, da nicotinamide riboside: kimantawar kwayar halitta ta NAD + precursor bitamin a cikin abincin mutum". Binciken shekara-shekara na Gina Jiki. 28: 115-30. Doi: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.

[5] Yue Yang, Anthony A. Sauve. NAD + metabolism: Bioenergetics, sigina da magudi don far. Biochim Biophys Dokar, 2016; DOI: 10.1016 / j.bbapap.2016.06.014.

[6] Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Gudanar da Tsawon Lokaci na Nicotinamide Mononucleotide Mitigates -arfafa Physarfin Jikin Jiki a cikin Mice. Cell Metab, 2016; DOI: 10.1016 / j.cmet.2016.09.013.

[7] Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen. NAD + metabolism a matsayin manufa don lafiyar rayuwa: Shin mun sami harsashin azurfa? Diabetologia, 2019; DOI: 10.1007 / s00125-019-4831-3.

[8] Ann Katrin-Hopp, Patrick Grüter, Michael O. Hottiger. Dokar Glucose Metabolism ta NAD + da ADP-Ribosylation. Sel, 2019; DOI: 10.3390 / sel8080890.

[9] Shuang Zhou, Xiaoqiang Tang, Hou-Zao Chen. Sirtuins da Resulin Resistance. Front Endocrinol (Lausanne), 2018; DOI: 10.3389 / fendo.2018.00748.