Samfur Description
Rimonabant foda video
Raw Rimonabant foda asali Haruffa
| name: | Rimonabant Foda (SR141716) |
| CAS: | 168273-06-1 |
| Kwayoyin Formula: | C22H21Cl3N4O |
| Girman kwayoyin halitta: | 463.8 |
| Shawarwar Melt: | 230 ° C - 240 ° C |
| Ajiye Temp: | Foda -20 ° C 3 shekaru |
| Color: | Grey-fari foda |
Rimonabant Background
Tarihin tarihi na Rimonabant ya dawo zuwa ƙarshen 1990s da farkon 2000s lokacin da masu bincike suka fara bincikar tsarin endocannabinoid da abubuwan da zai iya haifar da su a cikin matakai daban-daban na ilimin lissafin jiki, gami da ka'idojin abinci da daidaiton makamashi.
A cikin wannan lokacin, masana kimiyya sun gano masu karɓar cannabinoid a cikin jiki, wanda aka sani da masu karɓa na CB1, waɗanda galibi ana samun su a cikin kwakwalwa da nama.
Ƙarfafa fahimtar haɓakar tsarin endocannabinoid tsarin shiga cikin kula da abinci, kamfanonin harhada magunguna sun fara haɓaka ƙwararrun masu karɓar mai karɓar CB1 don ƙaddamar da kiba da yanayi masu alaƙa.
A cikin 1999, kamfanin harhada magunguna na Faransa Sanofi-Synthélabo (yanzu Sanofi) ya fara haɓaka wani magani mai suna Rimonabant.Rimonabant an tsara shi don zaɓin toshe masu karɓar CB1, yadda ya kamata ya hana ayyukan tsarin endocannabinoid.
An gudanar da gwaje-gwaje na asibiti don kimanta tasiri da aminci na Rimonabant a cikin kula da kiba da kuma rikice-rikice na rayuwa. Nazarin ya nuna sakamako mai ban sha'awa, yana nuna asarar nauyi da ingantawa a cikin abubuwan haɗari na zuciya da jijiyoyin jini, irin su matakan cholesterol da insulin juriya.
Dangane da kyakkyawan sakamako daga waɗannan gwaje-gwajen, Rimonabant ya sami amincewar tsari a cikin 2006 a cikin Tarayyar Turai a ƙarƙashin sunan kasuwanci Acomplia. Ita ce magani na farko da aka haɓaka musamman don maganin kiba a cikin sama da shekaru goma.
Duk da haka, duk da nasarar farko da ya samu, Rimonabant ya fuskanci kalubale da rikice-rikice.Rahotanni game da cututtuka na psychiatric, ciki har da rashin tausayi, damuwa, da kuma ra'ayin kashe kansa, sun bayyana a lokacin sa ido na tallace-tallace. kasashe da dama, ciki har da Tarayyar Turai a 2008.
Janyewar Rimonabant ya nuna mahimmancin yin la'akari da hankali da aminci da yiwuwar haɗari na kwakwalwa da ke hade da kwayoyi da ke yin amfani da tsarin endocannabinoid. Yayin da Rimonabant bai cika alkawarinsa na asali ba a matsayin maganin maganin kiba, ya ba da basira mai mahimmanci a cikin hadaddun hulɗar tsakanin endocannabinoid. tsarin da tsarin metabolism.
Tun lokacin da aka janye Rimonabant, ƙoƙarin bincike ya ci gaba da gano hanyoyin da za a iya amfani da su na yin amfani da tsarin endocannabinoid, amma tare da mayar da hankali kan haɓakar mahadi waɗanda ke rage haɗarin ciwon hauka da ke hade da toshewar mai karɓar CB1.
Rimonabant Foda
Rimonabant Powder wani abu ne na magunguna wanda ya sami kulawa don yuwuwar amfani da shi a fannin likitanci.Yana na cikin nau'ikan magunguna da aka sani da zaɓaɓɓen masu karɓar masu karɓa na cannabinoid. ci da nauyi.
Tsarin Foda na Rimonabant yana ba da damar sauƙaƙewa da watsawa a yayin aiwatar da tsari. propylene glycol.Halayen solubility na Rimonabant suna da mahimmancin la'akari yayin haɓakar haɓakawa.
Rimonabant tsarin aiki
Hanyar aikin Rimonabant ya haɗa da hulɗar ta tare da tsarin endocannabinoid a cikin jiki.
Lokacin da aka yi amfani da shi, Rimonabant yana ɗaure kuma yana toshe masu karɓar CB1, yana hana kunna waɗannan masu karɓa ta hanyar cannabinoids na endogenous kamar anandamide. tsari, ma'aunin makamashi, da kuma metabolism na lipid.
Musamman, toshewar masu karɓar CB1 ta Rimonabant yana shafar masu zuwa:
Gudanar da etauka
Masu karɓa na CB1 suna shiga cikin tsarin ci abinci da cin abinci.Lokacin da aka kunna masu karɓar CB1, suna ƙarfafa sakin neuropeptides da ke haifar da yunwa da kuma kara yawan kayan abinci. don rage cin abinci da rage cin abinci.
Kashe Makamashi
Tsarin endocannabinoid yana rinjayar kashe kuzarin makamashi ta hanyar sarrafa thermogenesis, tsarin da jiki ke samar da zafi kuma yana ƙone calories.Ta hanyar hana masu karɓar CB1, Rimonabant na iya inganta yawan kashe kuzarin makamashi, yana ba da gudummawa ga asarar nauyi.
Lipid Metabolism
CB1 receptor kunnawa yana hade da ƙara lipogenesis (mai ajiya ajiya) da kuma rage lipolysis (fat rushewa) .Rimonabant ta antagonism na CB1 rabe iya haifar da suppression na lipogenesis da kuma inganta lipolysis, yuwuwar haifar da raguwa a cikin jiki tara tara.
Yana da mahimmanci a lura cewa yayin da Rimonabant da farko yana aiki a matsayin antagonist mai karɓa na CB1, kuma yana iya nuna wasu ƙarin tasiri ko hulɗa tare da wasu masu karɓa ko tsarin a cikin jiki.Madaidaicin hanyoyin da tasirin Rimonabant na iya bambanta kuma har yanzu suna da batun ci gaba. bincike.
Hanyar aikin Rimonabant Powder daidai yake da na Rimonabant a cikin sauran nau'o'insa.
Lokacin da ake gudanar da Rimonabant Powder, ko dai ta baki ko ta hanyar tsari a cikin nau'i-nau'i daban-daban, yana fama da rushewa da sha a cikin jiki. Da zarar an shafe shi, yana hulɗa tare da tsarin endocannabinoid ta hanyar ƙaddamar da masu karɓar CB1 da aka samo a cikin kwakwalwa da nama na gefe.
Menene sakamakon Rimonabant?
Rimonabant, maganin rigakafin kiba, an fara haɓaka shi don taimakawa mutanen da ke fama da sarrafa nauyi.Amfaninsa na farko shine ikonsa na hana ci da haɓaka asarar nauyi.Musamman, Rimonabant an yi niyya don amfani dashi don dalilai masu zuwa:
Ƙuntataccen Abinci
An tsara Rimonabant don rage yawan ci da kuma inganta asarar nauyi ta hanyar toshe masu karɓar CB1 a cikin kwakwalwa da ke cikin tsarin abinci.
Weight Loss
Sakamakon rashin cin abinci, Rimonabant ana tsammanin zai haifar da asarar nauyi a cikin mutane masu kiba ko kiba. Gwajin gwaji na asibiti ya nuna cewa maganin Rimonabant zai iya haifar da raguwa mai yawa yayin da aka hade tare da abinci mai sarrafawa da motsa jiki.
Ingantattun Hanyoyin Halitta
Rimonabant ya nuna yuwuwar fa'idodi a cikin haɓaka sigogi na rayuwa waɗanda ke da alaƙa da kiba, kamar bayanan martaba na lipid, juriya na insulin, da alamomin haɗarin cututtukan zuciya.Ya yi niyya don haɓaka ingantaccen canje-canje a cikin waɗannan abubuwan haɓakar rayuwa, waɗanda galibi ana lalata su a cikin mutane masu nauyi.
Taimakon Kashe Sigari
An bincika Rimonabant don yuwuwar amfani da shi azaman taimako wajen dakatar da shan taba.An yi tunanin cewa ta hanyar toshe masu karɓar CB1, Rimonabant zai iya rage sha'awar nicotine da alamun cirewa, tallafawa mutane a cikin ƙoƙarinsu na daina shan taba.
Me yasa Rimonabant ke haifar da ciki?
Ba a fahimci ainihin hanyoyin da Rimonabant zai iya haifar da rashin tausayi ba. Duk da haka, nazarin da rahotanni na asibiti sun nuna yiwuwar haɗin gwiwa tsakanin amfani da Rimonabant da kuma ƙara yawan haɗari na ciki da sauran cututtuka na psychiatric.
Rimonabant, a matsayin mai zaɓaɓɓen mai karɓar mai karɓar cannabinoid, yana toshe ayyukan masu karɓar CB1 a cikin tsarin endocannabinoid. endocannabinoid tsarin, wanda zai iya ba da gudummawa ga canje-canje a cikin yanayi da jin daɗin tunanin mutum.
Bugu da ƙari, tsarin endocannabinoid yana da hannu a cikin ƙayyadaddun martani na danniya da kuma daidaitawar neurotransmitters irin su serotonin, wanda aka sani yana taka muhimmiyar rawa a cikin tsarin yanayi. Rushewar waɗannan matakai ta hanyar CB1 antagonism mai karɓa na iya haifar da bayyanar cututtuka.
Yana da mahimmanci a lura cewa amsawar mutum ga magunguna na iya bambanta, kuma ba duk wanda ya dauki Rimonabant zai fuskanci rashin tausayi ko abubuwan da ke da alaka da shi ba. kasuwa a kasashe da dama.Don haka a yanzu watakila ba sauki saya Rimonabant Powder a cikin kantin magani na gida.Idan kana so ka saya Rimonabant Foda a kan layi, har ma da yawa Rimonabant Powder maroki, kana buƙatar zaɓar abin dogara.
Idan kuna da damuwa game da bakin ciki ko wasu batutuwan da suka shafi lafiyar kwakwalwa, yana da mahimmanci ku tuntuɓi ƙwararren kiwon lafiya don kimantawa da jagora mai kyau.
Rimonabant janyewa da bincike mai gudana
Saboda damuwa na tsaro, musamman magungunan ciwon hauka, Rimonabant daga ƙarshe ya janye daga kasuwa a cikin ƙasashe da yawa. Duk da haka, bincike da ci gaba da magunguna da aka yi niyya ga tsarin endocannabinoid ya ci gaba, tare da mayar da hankali kan bunkasa madadin mahadi da hanyoyin kwantar da hankali wanda ke magance iyakokin Rimonabant. .
Binciken gaba na iya haɗawa da haɓaka fahimtar tsarin endocannabinoid, bincika yuwuwar aikace-aikacen endocannabinoid modulation a cikin yanayin kiwon lafiya daban-daban, da haɓaka amintattun magunguna masu inganci a cikin wannan filin.
Inda zan saya Rimonabant Foda?
Yana da mahimmanci a lura ko da akwai Rimonabant Powder da yawa don siyarwa akan layi.Ba a samuwa don siyan mutum ko amfani da shi ba.Rimonabant Powder yana amfani da farko a cikin bincike da saitunan ci gaba, ciki har da kamfanonin harhada magunguna da dakunan gwaje-gwaje, don manufar nazarin magungunan miyagun ƙwayoyi. Kaddarorin, gudanar da gwaje-gwaje na gwaji da gwaji na asibiti, da kuma samar da sababbin samfurori na miyagun ƙwayoyi.Saboda damuwa na aminci da tasiri mai tasiri, yana da mahimmanci don siyan Rimonabant Powder mai mahimmanci don kauce wa illa maras amfani.Yadda za a zabi wani abin dogara Rimonabant manufacturer, kana bukatar ka duba. Rahoton HPLC da COA masu zaman kansu.AASRAW shine mai samar da abin dogaro don amincewa. Muna ba da kyakkyawan ingancin Rimonabant Foda. Don oda mai yawa na Rimonabant Foda, zaku sami farashi mai fa'ida sosai.
Rahoton Gwajin Foda na Rimonabant-HNMR
Menene HNMR kuma Menene Bakan HNMR ke gaya muku?H Nuclear Magnetic Resonance (NMR) spectroscopy dabara ce ta nazarin sinadarai da ake amfani da ita wajen sarrafa inganci da bincike don tantance abun ciki da tsarkin samfurin da kuma tsarinsa na kwayoyin halitta. Misali, NMR na iya tantance gaurayawan da ke dauke da sanannun mahadi. Don mahaɗan da ba a san su ba, NMR ana iya amfani da su ko dai don daidaitawa da ɗakunan karatu na bakan gizo ko don fahimtar ainihin tsarin kai tsaye. Da zarar an san ainihin tsarin, ana iya amfani da NMR don ƙayyade daidaituwar kwayoyin halitta a cikin bayani tare da nazarin kaddarorin jiki a matakin kwayoyin halitta kamar musanya mai daidaituwa, canje-canjen lokaci, solubility, da yadawa.
Yadda za a saya Rimonabant Foda daga AASraw?
❶Don tuntuɓar mu ta tsarin binciken imel ɗin mu, ko kuma ku bar mana lambar ku ta whatsapp, wakilin sabis na abokin ciniki (CSR) zai tuntuɓar ku cikin awanni 12.
❷Don samar mana da adadin ku da adireshin ku.
❸CSR ɗin mu zai ba ku fa'ida, lokacin biyan kuɗi, lambar bin diddigi, hanyoyin bayarwa da ƙididdigar ranar isowa (ETA).
❹An gama biyan kuɗi kuma za a aika da kayan a cikin awanni 12.
❺Kayan da aka karɓa kuma a ba da sharhi.
Marubucin wannan labarin:
Dr. Monique Hong ya sauke karatu daga Kwalejin Kimiyya ta Burtaniya ta London Faculty of Medicine
Mawallafin Jaridar Kimiyya:
1. CC Carson
Sashen tiyata, Sashen Urology, Jami'ar North Carolina, Chapel Hill, NC,
2. I. Eardley
Asibitin Jami'ar St. James, Leeds, UK,
3. DJ Walker
Eli Lilly and Company, Indianapolis, IN, Amurka
4. WH Cordell
Eli Lilly and Company, Indianapolis, IN, Amurka
Babu wata hanya da wannan likita/masanin kimiyyar ya yarda ko ba da shawarar siyan, siyarwa, ko amfani da wannan samfur saboda kowane dalili. Aasraw ba shi da wata alaƙa ko alaƙa, a fayyace ko akasin haka, tare da wannan likitan. Manufar ambaton wannan likita shine yarda, yarda da kuma yaba da cikakken bincike da ayyukan ci gaba da masana kimiyyar da ke aiki akan wannan abu suka yi.
References
[1] Soyka M."
[2] Boyd ST, Fremming BA." Rimonabant - zaɓaɓɓen abokin adawar CB1." Ann Pharmacother.2005 Afrilu; 39 (4): 684-90.doi: 10.1345/aph.1E499.Epub 2005 Mar 8.PMID: 15755787
[3] Curioni C, André C.” Rimonabant don kiba ko kiba.” Cochrane Database Syst Rev.2006 Oct 18;2006(4):CD006162.doi: 10.1002/14651858.CD006162.pub2ID:
[4] Wierzbicki AS. "Rimonabant: endocannabinoid hanawa don ciwo na rayuwa. 2006
[5] Cox SL. "Rimonabant hydrochloride: wakili na bincike don gudanar da abubuwan haɗari na zuciya. Saukewa: 2005
[6] Bifulco M,Grimaldi C,Gazzerro P,Pisanti S,Santoro A.”Rimonabant: maganin hana kiba kawai? Shaida na yanzu akan tasirin sa na pleiotropic.
