N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw yana tare da kira da samar da damar daga gram zuwa tsari na N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide foda (CAS 681136-29-8), a karkashin tsarin CGMP da tsarin tsarin kulawa mai kyau.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder shi ne piperazinyl phenyl urea wanda tsarinsa ya bambanta da alkyl carbamates da haruffa-heterocyclic alpha-ketrocyclic kuma ya kasance mai hanawa da zaɓaɓɓen mai amfani da fatty acid amide hydrolase (FAAH) (IC50s = 34 da 33 nM a cikin ɗan adam da dan Adam) wanda zai iya don ƙetare jini-brain barrier.1 A 20 mg / kg, ya danganta da aikin FAAH ta hanyar rabuwa da aikin urea da ke samar da aniline da kuma FAAH-poperazinyl carbamate.

Samfur Description

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

name: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Tsarki: ≥99% (HPLC)
Kamancin: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Tsarin kwayoyin halitta: C19H19N5OS
Girman kwayoyin halitta: 365.459
Maimaitawa: 240.48
Maganin tafasa: 559.69 ° C a 760 mmHg
yawa: ~ 1.3 g / cm3
Ajiye Temp: Ajiye a + 4 ° C
Solubility: DMSO: ≥28mg / mL
Fassara mai nunawa: N20D 1.68
Color: Kyakkyawan crystalline
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Key: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Foda amfani a sake zagayowar:

1.Name:

N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid foda, JNJ 166101 Foda

2.Howene aikin N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Yin amfani da foda?

Hukumar FAAH ta jaddada tare da JNJ-1661010 na nuna jinkirin jinkiri na hulɗar tsakanin JNJ1661010 da shafin aiki, wanda aka inganta a yanayin zafi mafi girma. JNJ-1661010 ya kasance mai haɗari, mai ƙera tsari na tsari kamar yadda LC-ESI-MS ta bincika. Jirgin JNJ-1661010 tare da phenylthiadiazole a cikin ramin hydrophobic da phenylurea a cikin aljihu na hydrophilic na FAAH, JNJ-1661010 (20 mg / kg ip) ya hana FAAH daga akalla 85% don har zuwa 4 h bayan da aka dosing, sakamakon tarawa na lipid ethanolamides a cikin kwakwalwar kwari. JNJ-1661010 kashi-da gaske yana juyo da kayan da aka yi amfani da shi tare da matsakaicin tasiri na kimanin 90% a 30 min da ke gabatarwa a cikin Maɗaukakin Raunin Mild (MTI). JNJ-1661010 (20 mg / kg) ya sake canzawa ta hanyar 60.8% a 30 min a cikin ƙwayar cututtuka na raunin ƙwayar jijiyar ƙwayar jijiya. JNJ-1661010 (50 mg / kg ip) yana nuna babban haɓakawa na hyperalgesia a 30 min da ke gabatarwa a cikin ƙwayar ƙuƙwalwar ƙwayar katako mai zafi.
Rats da JNJ-1661010 (20 mg / kg ip) yana da Cmax na 26.9 μM plasma a Tmax na 0.75 h da Cmax a kwakwalwa ta 6.04 μM a Tmax na 2 h. JNJ-1661010 (20 mg / kg ip) ya hana kwakwalwa ta FAAH kuma ya haɓaka matakin AEA a kwakwalwar nama a cikin bera.

3.Warning on N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid foda

4.Further umarnin:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mafi girma (A cikin 1kg) za'a iya aikawa a cikin 3 workdays bayan biya.

6. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid Shafin Farko:

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

7. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamid foda Marketing:

Da za a bayar da shi a nan gaba.


III. N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide foda HNMR


IV. Yadda za a saya N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide foda daga AASraw?

1.To tuntube mu ta hanyar imel ɗinmutsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.


Ganin shafukan samfurinka da kafi so:

  Yadda ake amfani da Clenbuterol don asarar nauyi Mene ne nandrolone foda amfani da / nandrolone amfani?


Karin bayani game da samfurori masu dacewa,maraba don danna nan.


=

reviews

Babu reviews yet.

Ka kasance na farko da za a duba "N-phenyl-4- (3-phenyl-1,2,4-thiadiazol-5-yl) piperazine-1-carboxamide"

Your email address ba za a buga. Da ake bukata filayen suna alama *

Captcha *