Alfaxalone (23930-19-0) foda - Maƙerin masana'anta
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Alfaxalone

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Alfaxalone shine kwayar cututtukan cututtukan ƙwayoyin cuta wanda ke aiki tare da kaddarorin magungunan rigakafi. Alfaxalone an bayyana shi a matsayin 3-α-hydroxy-5-α-juna biyu-11, 20-dione, kuma yana da nauyin kwayar 332.5…

Samfur Description

Abubuwa Na Asali

Product Name Alfaxalone
CAS Number 23930-19-0
kwayoyin Formula C21H32O3
Formula Weight 332.48
nufin abu ɗaya ne Alphaxalone;

Alfaxalone;

23930-19-0;

5alpha-Ciki-3alpha-ol-11,20-dione;

Alfaxalonum.

Appearance White foda
Ajiye da kulawa Adana a cikin zafin jiki na daki mai sarrafawa -20 ° C

 

Bayanin Alfaxalone

Alfaxalone shine kwayar cututtukan cututtukan ƙwayoyin cuta wanda ke aiki tare da kaddarorin magungunan rigakafi. Alfaxalone an siffanta shi da 3-α-hydroxy-5-α-juna biyu-11, 20-dione, kuma yana da nauyin kwayoyin 332.5. Hanya ta farko don aikin maganin alfaxalone ita ce canzawar jigilar membrane chloride ion, wanda aka haifar ta hanyar ɗaura alfaxalone zuwa GABAA (gamma-aminobutyric acid) masu karɓar sel.

 

Alfaxalone Tsarin aikin

Alfaxalone yana haifar da suma ta hanyar yin aiki akan gamma aminobutyric acid subtype A (GABAA) masu karɓar aiki a cikin tsarin juyayi na tsakiya (CNS). Wadannan masu karɓa sune tashoshin haɗin gwanon ionotropic, kuma GABA shine jigon haɗarin su. GABA shine babban mai hana neurotransmitter a cikin CNS. Bayan an kunna mai karba, tashar tana budewa kuma tana inganta aikin chloride a cikin kwayar, wanda ke haifar da hauhawar hawan membrane na postynaptic. A ƙananan haɗuwa, alfaxalone yana inganta yanayin chloride a halin yanzu ta hanyar tashar chloride; amma a mafi girman hankali, yana aiki azaman GABA agonist, kamar yadda yake barbiturates. Sakamakon ƙarshe shine zurfin nutsuwa ko shigar da maganin sa barci, gwargwadon kashi da hanyar gudanarwar.

 

Alfaxalone Aikace-aikacen

Alfaxalone, wanda aka fi sani da alphaxolone ko alphaxalone kuma ana amfani dashi a ƙarƙashin sunan kasuwanci Alfaxan, shine kwayar cututtukan cututtukan kwakwalwa da ke amfani da ƙwayoyi masu rauni a cikin karnuka da kuliyoyi. Ana iya amfani dashi azaman wakili na shigar da ciki ko kuma don maganin rigakafin jiki.

 

Alfaxalone Fa'idodi & Rashin Amfani

  • abũbuwan amfãni:

Alfaxalone yana haifar da canji kaɗan a cikin bugun zuciya ko hawan jini lokacin da ake amfani da allurai masu dacewa a asibiti ga marasa lafiya. Alfaxalone yana da mahimman bayanai na warkewa, gajere ne, kuma bashi da riba. Wadannan halaye suna sanya alfaxalone manufa don amfani azaman wakili na shigar da ciki ko kuma samar da maganin rigakafin allura.

Hakanan za'a iya amfani da Alfaxalone a cikin intramuscularly, don haka ana iya amfani dashi don kwantar da marasa lafiya marasa aiki. Lokacin da ake amfani da alfaxalone don kwantar da hankalin mai haƙuri matakin shine 1-3mg / kg IM kuma yawanci ana haɗa shi tare da opioid don ƙwanƙwasawar mafi kyau.

Lokacin da ake amfani da alfaxalone don raunin cikin kwiyakwiyi 'yan kwikwiyo sun fi faɗakarwa kuma suna rayuwa tare da ingantaccen maki na AGPAR idan aka kwatanta da propofol.

 

  • disadvantages:

Alfaxalone yana haifar da ciwon bugun numfashi na dogaro, tare da yuwuwar faruwar cutar biyo bayan saurin allurar IV. Yi shiri don intubate, samar da tallafi na oxygen, da iska yayin amfani da alfaxalone don ko dai shigar da ciki ko kwantar da hankali.

Gudanar da aiki mai yawa na alfaxalone na iya haifar da baƙin ciki na zuciya da jijiyoyin jini, tare da raguwa mai mahimmanci a cikin duka fitowar zuciya da hawan jini. Yawan alfaxalone yakamata a sanya shi a hankali cikin marasa lafiya waɗanda suka rage wadatar zuciya da jijiyoyin jijiyoyin jiki ko kuma basu da ƙarfi a yanayin rayuwa.

Alfaxalone ba ya ba da wata cuta, saboda haka ya kamata a yi amfani da shi tare da maganin opioid mai dacewa don hanyoyin ciwo.

Lokacin da aka gudanar alfaxalone cikin intramuscularly ƙarar allura na iya zama babba, mai haifar da zafi akan allura. Babban girman kuma na iya sa gudanar da gwamnati cikin ƙalubale idan akwai iyakance taga don allura saboda halin haƙuri. Gwamnatin Alfaxalone na iya haifar da mummunan rauni na murmurewa wanda ke da nau'ikan digiri na motsawa, faɗakarwa, da / ko myoclonus.

 

reference

[1] Whittem T, Pasloske KS, Heit MV da sauran su. (2008) Magungunan magani da maganin alfaxalone a cikin kuliyoyi bayan guda ɗaya kuma da yawa cikin maganin cikin Alfaxan a asibitoci da magungunan supraclinical. J Vet Pharmacol Ther 31 (6), 571-579.

[2] Ferre PJ, Pasloske K, Whittem T et al. (2006) Plasma pharmacokinetics na alfaxalone a cikin karnuka bayan wani ƙwayar intravenous bolus na Alfaxan-CD. Vet Anaesth Analg 33, 229-236.

[3] Muir W, Lerche P, Wiese A et al. (2009) Kwayoyin cututtukan zuciya da na maganin cututtukan asibiti da na maganin alfaxalone a cikin kuliyoyi. Vet Anaesth Analg 36, 42-54.

[4] Clarke KW, Gyara CM, Hall LW, eds. (2014). "Babi na 15: Anesthesia na kare". Magungunan dabbobi na dabbobi (edita na 11). Oxford: WB Saunders. shafi na 135-153.

[5] Varga M (2014). "Fasali na 4: Anesthesia and Analgesia". Littafin rubutu na Rabbit Medicine (2nd ed.). Butterworth-Heinemann. shafi na 178-202.

[6] Nieuwendijk H (Maris 2011). "Alfaxalone". Supportungiyar Tallafi ta Magungunan Kiwan dabbobi & Ciwon Magunguna. An sake dawo da Yuli 14, 2017.

[7] Zeltzman P (Nuwamba 17, 2014). "Me yasa Gudanar da Alfaxalone ke Bukatar 'Yan Ilimi". Labaran Likitocin dabbobi. An sake dawo da Yuli 14, 2017.