Allopregnanolone (516-55-2) foda - Maƙerin Maƙerin Masana'antu
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Allopregnanolone

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Allopregnanolone, wanda aka fi sani da Sepranolone da Isopregnanolone, mai karɓar GABA ne wanda ke canza ƙyamar steroid da nau'in 11-betahydroxysteroid dehydrogenase nau'in 1 (11'-HSD1)…

Samfur Description

Abubuwa Na Asali

Product Name Allopregnanolone
CAS Number 516-55-2
kwayoyin Formula C21H34O2
Formula Weight 318.5
nufin abu ɗaya ne NSC-97078; U-0949; UC-1010; NSC97078; U0949; UC1010; NSC 97078; U 0949; UC 1010; Isopregnanolone; Allopregnanolon; Sepranolone; 516-55-2; 5alpha-Ciki-3beta-ol-20-daya
Appearance White foda
Ajiye da kulawa Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).

 

Bayanin Allopregnanolone

Allopregnanolone, wanda aka fi sani da Sepranolone da Isopregnanolone, mai karɓar GABA ne wanda ke canza antagonist na steroid da nau'in 11-betahydroxysteroid dehydrogenase na 1 (11'-HSD1). Sepranolone wani katafaren mahaɗin ne, wanda aka samar da shi cikin jiki, wanda ke canza tasirin Allopregnanolone (ALLO). ALLO yana da ƙarfin neurosteroid wanda ke cikin damuwa - da yanayin alaƙa wanda ya haɗa da Tourette zuwa OCD, PTSD, caca mai tilasta, jaraba, PMDD, Migraine na Mace.

 

Ayyukan Allopregnanolone na Aiki

Hadin gwiwar kwayoyin halitta

Allopregnanolone shine ƙarancin hana haihuwa ciki neurosteroid. An yi shi ne daga progesterone, kuma yana da kyakkyawar mahaɗin allosteric na aikin γ-aminobutyric acid (GABA) a mai karɓar GABAA. Allopregnanolone yana da tasiri irin na sauran masu amfani da kayan aiki na GABA a cikin mai karɓar GABAA kamar su benzodiazepines, gami da ɓacin rai, kwantar da hankali, da kuma ayyukan da ke sa maye. Ba tare da ɓata lokaci ba ya samar da allopregnanolone yana aiki a cikin aikin neurophysiological ta hanyar daidaitawa na mai karɓar GABAA da kuma daidaita aikin da yawa masu gyaran allo da kuma agonists a mai karɓar GABAA.

Allopregnanolone yana aiki ne a matsayin mai ƙarfin haɓakar mai karfin GABAA. Duk da yake allopregnanolone, kamar sauran neurosteroids masu hana ƙarfi kamar su THDOC, suna yin gyare-gyare da kyau duk masu karɓar mai karɓar GABAA, waɗancan hanyoyin da ke ɗauke da δ subunits suna nuna mafi girman ƙarfi. Hakanan an gano Allopregnanolone don yin aiki azaman mai amfani da allo na GABAA-ρ mai karɓar, kodayake abubuwan wannan aikin ba su da tabbas. Baya ga ayyukanta akan masu karɓar GABA, allopregnanolone, kamar progesterone, an san shi a matsayin mai rikodin allosteric mara kyau na masu karɓar nACh, kuma yana bayyana yana aiki azaman mai rikodin allosteric mara kyau na mai karɓar 5-HT3. Tare da sauran neurosteroids masu hanawa, allopregnanolone ya bayyana yana da ƙarancin aiki ko babu a wasu tashoshin ion, wanda ya haɗa da masu karɓar NMDA, AMPA, kainate, da glycine.

 

Magungunan antidepressant

Hanyar da neurosteroid GABAA mai karɓar PAMs kamar brexanolone ke da tasirin antidepressant ba a sani ba. Sauran masu karɓar GABAA PAMs, kamar su benzodiazepines, ba a tunanin su a matsayin masu kwantar da hankula kuma ba su da wani inganci, duk da cewa likitocin da ke ba da maganin Alprazolam don ɓacin rai a da. Neurosteroid GABAA receptor PAMs sanannu ne don yin hulɗa tare da masu karɓar GABAA da ƙananan alƙaluma daban da na benzodiazepines. A matsayin misalai, mai karɓar GABAA-mai karfin neurosteroids na iya fifita target subunit mai ƙunshe da masu karɓar GABAA, da haɓaka haɓakar tonic da phasic tsakanin masu karɓar GABAA. Zai yiwu kuma neurosteroids kamar allopregnanolone na iya yin aiki a kan wasu maƙasudin, gami da masu karɓar maganin ƙwaƙwalwar membrane, T-type irin ƙarfin lantarki mai ƙwanƙwasa, da sauransu, don sasanta tasirin tasirin antidepressant.

 

Aikace-aikacen Allopregnanolone

Allopregnanolone shine keɓaɓɓen steroid wanda ke aiki akan ƙwaƙwalwa. A matsayin magani, ana siyar dashi a ƙarƙashin sunan Zulresso kuma ana amfani dashi don magance baƙin ciki bayan haihuwa. Ana amfani dashi ta hanyar allura a cikin jijiya sama da awanni 60 a karkashin kulawar likita.

Illolin Allopregnanolone na iya haɗawa da laulayi, bacci, bushe baki, walƙiya mai zafi, da rashin hankali. Yana da neurosteroid kuma yana aiki azaman mai gyaran allo mai kyau na mai karɓar GABAA, babban maƙasudin ilimin halittu na mai hana ƙwayar t-aminobutyric acid (GABA).

An amince da Allopregnanolone don amfani da lafiya a cikin Amurka a cikin 2019. Hukumar Abinci da Magunguna ta Amurka (FDA) tana ɗaukar shi a matsayin magani na ajin farko. Lokaci mai tsawo na gwamnati, da kuma kuɗin magani na lokaci ɗaya, sun haifar da damuwa game da samun dama ga mata da yawa.

 

reference

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