J 147 foda (1146963-51-0) | neuroprotective da neurotrophic fili
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J 147 foda

Rating: SKU: 1146963-51-0. category:

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa umurnin taro na J 147 foda (1146963-51-0), ƙarƙashin tsarin CGMP da tsarin kula da inganci mai kyau.

J147 foda an fara gina shi a 2011, kuma masu bincike sunyi nazari da dama wanda ya nuna cewa zai iya canza asarar ƙwaƙwalwar ajiya kuma jinkirin jinkirin Alzheimer ta cikin ƙananan yara. Amma har sai wannan bincike, ba su san yadda yake aiki a cikin sel ba. Sun sami damar nuna cewa J147 foda yayi aiki ta hanyar amfani da ATP, mai gina jiki a cikin mitochondria da kuma hanyar samar da makamashi ta jiki. Lokacin da J147 foda ya kasance, ana kare kaya daga abubuwan da ke tattare da tsufa. Ƙarin gwaje-gwaje sun nuna cewa J147 foda yana ƙaruwa da matakan ATP kuma yana inganta lafiyar jiki, mafi haɓaka mitochondria

Samfur Description

 

J 147 foda

 

 


 

Raw J 147 ƴan Maɗallan Maɗaukaki

 

name: J 147 foda
CAS: 1146963-51-0
Formula kwayoyin: C18H17F3N2O2
Kwayoyin Weight: 350.3349896
Shawarwar Melt: 177-178 ° C
Ajiye Temp: 4 ° C
Color: White ko kashe farin foda

 


 

Raw J 147 foda don bunkasa aikin kwakwalwa da kuma ƙarin ƙarfin haɓaka

 

names

J 147 foda

 

J 147 (1146963-51-0) Sashin amfani

Yin amfani da tsarin gano miyagun ƙwayoyi don cutar Alzheimer (AD) wanda ya dogara da ƙwayoyin cuta da yawa na tsufa, mun gano mahimmin fili tare da inganci a cikin ƙwaƙwalwar ƙwaƙwalwa da samfurin dabbobin AD. Tunda wannan mahaɗin, J-147 foda, shine phenyl hydrazide, akwai damuwa cewa za'a iya haɗuwa zuwa amines / hydrazines masu ƙoshin lafiya waɗanda suke da yiwuwar cutar kanjamau. Don bincika wannan yiwuwar, mun bincika metabolites na J 147 foda a cikin ɗan adam da linzamin kwamfuta microsomes da linzamin plasma. An nuna cewa J-147 (1146963-51-0) foda ba ta haɗuwa zuwa amines mai ƙanshi ko hydrazines, cewa sikeli yana da tsayayyen yanayi, kuma cewa masu maye gurɓataccen abu kuma ba sa iya aiki. An yanke shawarar cewa manyan metabolites na J 147 (1146963-51-0) foda na iya taimakawa ga ta nazarin halittu a cikin dabbobi.
J 147, wanda aka samo daga curryin curryin curry, yana da ƙarancin guba kuma a zahiri yana sake lalata lalacewar ƙwayoyin cuta masu alaƙa da Alzheimer.

J 147 (1146963-51-0) shi ne furotin mitochondrial wanda aka sani da ATP synthase, musamman ATP5A, wani ɓangaren wannan furotin. ATP synthase yana da hannu a mitochondrial ƙarni na ATP, wanda sel amfani da makamashi.

Masu bincike sun nuna cewa ta hanyar rage ayyukan ATP synthase, sun iya kare kwayayyun neuronal daga yawan kwayoyin da ke hade da tsufa na kwakwalwa. Ɗaya daga cikin dalili na wannan sakamako neuroprotective ana zaton shi ne muhimmancin rashin haɓaka a cikin lalacewar neuronal cell.

Rashin ƙyama shi ne tsarin ilimin maganin da ake amfani da shi a cikin abin da aka lalata magunguna da kuma kashe su ta hanyar cire masu karɓar ragamar masu cin hanci da rashawa. Yi la'akari da shi kasancewa kamar sauƙi mai sauyawa yana kunna kuma kashewa da sauri don ya ƙare har ya sa hasken wutar ya busa.

Kwanan nan, an nuna ma'anar ATP na hana hana neuroprotection akan lalacewa ta hanzari a cikin binciken linzamin kwamfuta [4]. Nazarin na biyu ya nuna cewa nau'in linzamin kwamfuta wanda ke nuna nau'in mutun na mutunci 1 (hIF1) wanda ke haifar da dakatar da ATP synthase, ya fi dacewa da mutuwar ne bayan mutuwar excitotoxic. Wannan bayanan ya dace da wannan sabon binciken J 147 na foda, wanda karuwa a IF1 a cikin mice ya rage aikin ATP synthase (musamman ATP5A) kuma ya kasance neuroprotective.

 

Gargaɗi akan Raw J 147 foda

Bayanin da aka gabatar a nan ya nuna cewa foda-JN XXUM yana da ikon ceton ƙarancin da ya dace lokacin da aka gudanar da shi a karshen lokaci a cikin cutar. Hanya ta J-147 foda don inganta ƙwaƙwalwar ajiya a cikin tsohuwar ƙwaƙwalwar ƙarancin AD an haɗa shi tare da ƙaddamar da ƙananan ƙwayoyi na NGF (ƙananan factor factor) da kuma BDNF (ƙwararren ƙwayoyin neurotrophic) da kuma yawancin sunadaran BDNF wadanda ke da muhimmanci ga ilmantarwa da ƙwaƙwalwa. Misali tsakanin J-147 (147-1146963-51) foda da donepezil a cikin samfurin scopolamine ya nuna cewa yayin da mahadi biyu suka kasance daidai a lokacin tunawa da ƙayyadadden lokaci, J-0 foda yana da fifiko a yayin da aka kwashe ƙwaƙwalwar sararin samaniya da haɗuwa da ɗayan biyu mafi kyau ga abubuwan da ke cikin al'ada da kuma ƙwaƙwalwar ajiya.

 

Karin bayani

Ciwon Alzheimer shine ciwon kwakwalwa na ci gaba, kwanan nan ya zama babban matsayi na uku na mutuwa a Amurka kuma yana shafar fiye da miliyan biyar na Amurka. Har ila yau, shi ne mafi yawan abin da ke faruwa na tsoratar da tsofaffi, a cewar Cibiyar Kula da Lafiya na Ƙasar. Duk da yake mafi yawancin kwayoyi da suka samo asali a cikin shekaru 20 da suka gabata sun sa ido a cikin kwakwalwa (amyloid plaque deposits) a cikin kwakwalwa (wanda shine alamar cutar), 'yan kalilan sun tabbatar da tasiri a asibitin.

"Yayinda yawancin kwayoyi suka fara a cikin shekaru 20 da suka gabata sun sa ido a kan kwakwalwar amyloid a cikin kwakwalwa (wanda shine alamar cutar), babu wanda ya tabbatar da tasiri a asibiti," in ji Schubert, babban marubucin binciken.

Shekaru da dama da suka wuce, Schubert da abokan aikinsa sun fara magance cutar daga sabon kusurwa. Maimakon magance amyloid, jaridar ta yanke shawara ta yi la'akari da babban haɗari ga ƙwayar cutar. Yin amfani da fuska da kwayar cutar kan tsofaffin ƙwayoyin kwakwalwa, sun hada J 147 (1146963-51-0) foda.

A baya, ƙungiyar ta gano cewa foda J-147 na iya hanawa har ma da juyawar ƙwaƙwalwar ajiya da cututtukan Alzheimer a cikin ƙananan yara waɗanda ke da fasalin tsarin gadonsu Alzheimer's, samfurin linzamin kwamfuta da aka fi amfani da shi. Koyaya, wannan nau'in cutar ya ƙunshi kusan kashi 1 cikin XNUMX na al'amuran Alzheimer. Ga kowa da kowa, tsufa ita ce tushen haɗarin farko, in ji Schubert. Teamungiyar ta so binciko tasirin ɗan takarar miyagun ƙwayoyi a kan nau'in beraye waɗanda ke tsufa cikin sauri kuma suna fuskantar fasalin rashin hankali wanda ya fi kamanceceniya da cutar ɗan adam da ke da shekaru.

 

J 147 Raw Foda

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mafi girma (A cikin 1kg) za'a iya aikawa a cikin 3 workdays bayan biya.

 

Raw J 147 foda Marketing

Da za a bayar da shi a nan gaba.

 


 

Yadda za a saya J 147 foda daga AASraw

 

1.To tuntube mu ta hanyar imel ɗinmu tsarin bincike, ko skype na kan layiwakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.