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Lorcaserin (Belviq) foda

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SKU: 616202-92-7. category:

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa tsari na murya na Lorcaserin (Belviq) foda (616202-92-7), a karkashin tsarin CGMP da tsarin kula da inganci mai kyau.

Samfur Description

Lorcaserin Gabatarwa

Samar da ƙwayar magungunan asarar lafiya da lafiya mai tsanani shine aiki mai wuyar gaske. Ƙoƙari a baya sun zo tare da tasiri masu yawa irin su lalacewar zuciya. Abin takaici, wani sabon binciken ya ce adadin kwayar hasara mai nauyi zai iya taimaka maka zubar da kisa ba tare da yin hadaya da lafiyar zuciyarka ba. Lorcaserin wata kwayar cutar ne mai cin gashin gaske, wadda FDA ta yarda a 2012. Amma abin da ke lorcaserin? To, a ƙasa ƙasa ne mai cikakken bayani game da maganin miyagun ƙwayoyi, tsarin da ya shafi sinadarai da kaddarorinsa, amfani, sashi, tsare-tsaren, da sauransu.

Sunan kamfanin: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Lorcaserin (Belviq) foda


I.Lorcaserin (Belviq) foda ainihin Maballin:

name: Lorcaserin (Belviq) foda
CAS: 616202-92-7
Kwayoyin Formula: C11H14ClN
Girman kwayoyin halitta: 195.692
Shawarwar Melt: 212 ° C
Ajiye Temp: RT
Color: White zuwa kashe-farin foda


Lorcaserin Gabatarwa

Samar da ƙwayar magungunan asarar lafiya da lafiya mai tsanani shine aiki mai wuyar gaske. Ƙoƙari a baya sun zo tare da tasiri masu yawa irin su lalacewar zuciya. Abin takaici, wani sabon binciken ya ce adadin kwayar hasara mai nauyi zai iya taimaka maka zubar da kisa ba tare da yin hadaya da lafiyar zuciyarka ba. Lorcaserin wata kwayar cutar ne mai cin gashin gaske, wadda FDA ta yarda a 2012. Amma abin da ke lorcaserin? To, a ƙasa ƙasa ne mai cikakken bayani game da maganin miyagun ƙwayoyi, tsarin da ya shafi sinadarai da kaddarorinsa, amfani, sashi, tsare-tsaren, da sauransu.

Sunan kamfanin: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Da ke ƙasa akwai tsarin sunadarai na lorcaserin a cikin 3-D conformation.

Lorcaserin (Belviq) foda

Gidaran Kayan Gida na Lorcaserin (belviq) (CAS 616202-92-7)

Da ke ƙasa an taƙaita sunadarai sunadarai na Lorcaserin (belviq); An gabatar da su a teburin da ke ƙasa don kallon kallo.

Sunan Yanki Darajar Abinci
Ƙididdigar Ƙididdigar Ƙwararren Ƙidaya 1
Atomar Atom Count 0
Ba'a ƙayyade Bond Stereocenter Count ba 0
An ƙayyade Bond Stereocenter Count 0
Abubuwan da aka ƙayyade Atom Stereocenter Count 0
An tsara Atom Stereocenter Count 1
Tashin Atom Count 13
Dokar da ta dace 0
Kwararren Canonicalized Gaskiya
XLogP3-AA 2.7
Zama daidai 195.081 g / mol
Monoisotopic Mass 195.081 g / mol
Ƙungiyar Tashin Lafiya na Topological 12 A ^ 2
Hadaddiyar 172
Ƙididdigar Lissafin Rotatable 0
Hydrogen Bond Acceptor Count 1
Binciken Gida na Hydrogen Bond 1
kwayoyin Weight 195.69 g / mol
Ƙunƙasawar Maɗaukaki

pKa = 9.98 (est)

Bayani mai sauƙi na ƙwayar Lorcaserin HCL

Lorcaserin (Belviq) wani abu ne mai ciwo mai cin nama wanda Arena Pharmaceuticals ya tsara. Yana da wani nau'i na magungunan da aka kira su agonists mai karɓa na serotonin. Ana tsara shi don taimaka maka jin dadi bayan ka ci abinci marar abinci. Yana hana ci ta hanyar kunna 5-HT2C masu karɓa, waxanda suke da nau'o'in masu karɓa na serotonin a cikin wani ɓangare na kwakwalwa (hypothalamus) wanda ke sarrafa ci. Lokacin da suke sigina jikinka don jin dadi, kayi cin abinci kadan, saboda haka ya ƙare nauyi a cikin lokaci mai tsawo.

Belviq, wanda sunansa na sunadaran (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate, ana nufin ana daukar shi ta bakin rai. Nauyin kwayoyinsa shine 241.16 g / mol, kuma maƙasudin mahimmanci shine C11H15Cl2N • 0.5H2O. Its tsarin tsari shine a nan:

Lorcaserin (Belviq) foda

Rashin ƙarancin Lorcaserin hydrochloride hemihydrate cikin ruwa ya fi 400 mg / ml. Kwamfutar Belviq yana da nau'in nau'i na 10.4 na crystalline lorcaserin hydrochloride hemihydrate (wani farin zuwa kashe-fata foda), wanda yake daidai da 10.0 milligrams anhydrous lorcaserin hydrochloride. Har ila yau, akwai wasu abubuwa masu hade, ciki har da NF, magnetium, NP, FD & C Blue #2 tafkin aluminum, USP, polyethylene glycol NF, barazanar polyvinyl USP, colloidal silicon dioxide NF, croscarmellose sodium NF, microcristalline cellulose da hydroxypropyl cellulose NF.

Ayyukan aikin gyaran na Lorcaserin

Bisa ga ka'idojin jagorancin Abinci da Drug Administration (2007), Lorcaserin na iya taimaka wa mazan girma wajen samun asarar asibiti. Wannan ƙwayar magungunan asarar ya ce ya yi aiki sosai a yayin da aka haɗa tare da ƙara yawan aikin jiki da kuma cin abinci maras calorie. Zai iya taimakawa wajen taimakawa tare da kulawa mai nauyi, musamman ma mutanen da suke da karba (akalla 27 kg / m2), ko obese (BMI na akalla30 kg / m2). Wannan magani zai iya taimaka wa waɗanda ke da nauyin abu guda ko fiye da nauyin, kamar su ciwon sukari na 2, dyslipidemia, ko hauhawar jini.

Lorcaserin wani nau'i ne mai cike da ciwon nama wanda ke aiki a matsayin 5-HT2C agonist mai karɓa a cikin hypothalamus tare da zaɓin aiki na sau goma sha biyar ƙarin dangantaka ga 5-HT2C masu karɓa fiye da 5-HT2A da kuma yin watsi da 100 sau da yawa don zaɓin aiki ga 5-HT2C masu karɓa fiye da na 5-HT2B.

Masu karɓar 5-HT2C suna kusan kusan a cikin kwakwalwar mutum kuma za'a iya samun su a cikin thalamus, hypothalamus, cortex, hippocampus, choroid plexus, cerebellum, da amygdala. Ƙarawar da masu karɓar 5-HT2C ta motsawa a hypothalamus ta kunna samar da POMC (proopiomelanocortin) don haka inganta ƙimar ragewa ta hanyar jin dadi. Wannan jayayya yana goyan bayan goyan bayan gwaji da sauran binciken bincike. Duk da yake an yi tunanin cewa masu karɓar 5-HT2C zasu taimaka wajen gyaran abincin, cikewar gizon endocrin, da yanayi, ainihin yanayin aiki a ka'idar ci abinci ba a sani ba.

Receptor EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

Amfani da launi na Lorcaserin HCL

Idan muka yi la'akari da ƙwallafin kirki na ainihi na Lorcaserin, to wannan shine tabbas mafi asarar nauyi a kasuwa a yau. Wasu mutane da yawa, watau, waɗanda ke da nauyin kiwon lafiyar da suke da nauyin nauyi ko wadanda suke da kariya suna iya amfani da wannan samfuri mai yawa.

Idan aka yi amfani da shi tare da shirin likita, likitancin calorie, da salon rayuwa, Lorcaserin zai iya taimakawa mutum yayi yawa fiye da rasa nauyi - zai iya taimakawa wajen rage yawan hadarin kiwon lafiya wanda ke hade da kiba, ciki harda hawan jini, ciwon sukari, cututtukan zuciya, da kuma mutuwar farko.

Bisa ga cibiyar Cibiyar Kula da Cututtuka, lalata 5 zuwa 10 kashi dari na nauyin jikin jiki zai iya gabatar da wasu sha'anin kiwon lafiya kamar gyaran jini, da cholesterol da jini, da kuma karfin jini.

Sashin ilimin launi na Lorcaserin HCL

Dole ne a dauki magunguna biyu a kowace rana. Saboda haka kuna bukatar ɗaukar kwayoyin 60 kowace wata. A cewar FDA, ya kamata mutum ya yi amfani da miyagun ƙwayoyi yayin sauran rayuwarsa don kiyaye lafiyar lafiya.

Yana da mahimmanci a lura cewa an sami sakamako mai kyau bayan 12 makonni. Idan ba za ku rasa akalla 5 bisa dari na ma'aunin jikin ku ba, to, ana shawarce ku daina amfani da kwaya. Ko da ci gaba da yin amfani da shi, ba zai yiwu ba za ku iya cimmawa kuma ku ci gajiyar asarar asibiti.

Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Ciki

Yana da kyau a tuna cewa masu sana'a na kiwon lafiya sun tsara wannan miyagun ƙwayoyi saboda sun yanke hukunci cewa amfanin da kake samu shine mafi girma fiye da hadari na sakamako masu illa. Yawancin mutanen da suka yi amfani da wannan miyagun ƙwayoyi ba su nuna mummunar tasiri.

Kafin kayi karba, bari likitan ku ko likita ya san ko kuna shan magani ga miyagun ƙwayoyi; ko kuma kana da wasu abubuwan allergies. Lorcaserin yana dauke da sinadaran aiki wanda zai iya haifar da halayen rashin lafiyan ko wasu batutuwa. Ka tambayi magungunan likitancinka don ba maka cikakkun bayanai.

Kafin yin wannan magani, sanar da likitan ku ko likita game da tarihin lafiyarku, musamman matsalolin koda, ciwon sukari, matsalar hanta, cututtukan zuciya (ciki har da zuciya, damun zuciya, jinkirta zuciya, rashin zuciya) matsaloli wanda zai iya ƙara haɗari daɗaɗɗa mai raɗaɗi / kwanciya a cikin maza (ciki har da azzakari maras kyau, cutar Peyronie, myeloma mai yawa, ciwon sikila anemia, cutar sankarar bargo).

Wannan kwayar cutar ta ci abinci na iya sa ka rage tunaninka ko damuwa. Marijuana ko barasa na iya sa wadannan sakamako ya fi muni. Kada kayi amfani da kayan aiki, kullun, ko yin wani abu da ke buƙatar jijjiga har sai kun iya yin shi a hankali. Yi iyakacin giya da kuma magana da likitanka idan kana amfani da marijuana.

Idan kana fuskantar wata hanya ta jiki, yana da hankali ka gaya wa likitanka ko likita game da duk samfurorin da kake dauka (ciki har da magungunan marasa amfani, kayan daji, da kwayoyi masu magani).

Idan kana zaune tare da ciwon sukari, wannan nau'in asarar nauyi zai iya shafar jini na jini. Tabbatar ka duba matakin jinin jininka a lokuta na lokaci kamar yadda aka shawarta kuma ka raba sakamakonka tare da likita. Bari likitan ku san idan kuna da alamun sukari. Kwararren likita naka na iya buƙatar daidaita tsarin motsa jiki, abinci ko ciwon sukari.

Ba za a dauki wannan miyagun ƙwayar a lokacin daukar ciki domin zai iya cutar da jariri ba a haifa ba. Ka tambayi likitanka game da aikace-aikacen ƙwayoyin haihuwa. Idan kun kasance mai ciki ko zama ciki, gaya wa ma'aikacin lafiyar ku a nan da nan.

Ya zuwa yanzu, ba a sani ba ko wannan magani ya shiga cikin nono madara. Don hana yiwuwar hadarin zuwa jaririn, nono a lokacin amfani da wannan magani bai bada shawara ba. Tabbatar ka shawarci likitan ka kafin ka nono.

Karanta Rubutun Bayanin Mai amfani a hankali idan akwai daga likitanka kafin ka fara amfani da lorcaserin da duk lokacin da ka cika cika. Idan kana da wata tambaya, tambayi likitan ku ko likita.

Yi amfani da kwayar cutar ta ci tare da ko ba tare da cin abinci ba kamar yadda jagoran ka ke so, yawanci sau biyu a kowace rana. Yi amfani da wannan miyagun ƙwayoyi a kai a kai don samun mafi yawan daga ciki. Don taimaka maka ka tuna, kai kwaya a lokuta guda a kowace rana.

Lorcaserin shine maganin miyagun ƙwayoyi. Kada ka ƙara yawan kashi ko ka dauki wannan kwaya fiye da yadda aka tsara. Yanayin da kake da shi bazai inganta kowane sauri ba, kuma hadarin illa na iya ƙara.

Hanyoyin maganin miyagun ƙwayoyi na iya faruwa a yayin da ake amfani da kwayoyi masu amfani tare da kwayar ƙwayar lorcaserin. Faɗa wa likitanku game da dukkanin kwayoyi da kuke amfani da su a halin yanzu, da kowane takardar sayan da kuka fara ko dakatar da yin amfani da su.

Ba a yarda da kwayar lalata kwayar cutar ta Magnetta ba don ba ta amfani da yara masu tsufa ba fiye da shekaru 18.

Yaya ya kamata in dauki murfin Lissafin Cizonal HCL?

Kada ku ƙyale, karya, ko kuɓutar da kwamfutar hannu mai ɗorewa. Kamar haɗiye shi duka.

Maimakon ciwon ciwon sikila ne kawai wani ɓangare na tsarin kulawa wanda ya kamata ya hada da motsa jiki, kula da nauyi, cin abinci, da kuma jarrabawar jinin ku kullum. Bi da maganin ku, abinci mai gina jiki, da kuma motsa jiki yana ci gaba sosai.

Ajiye magunguna a dakin da zazzabi daga zafi da damshi.

Tsaya rikodi na yawan kwayoyi da aka yi amfani da su daga dukan kwalabe. Labaran asarar ƙwayar murzarin ƙwayar kwayar cutar kwayoyi ne mai amfani da miyagun ƙwayoyi, kuma ya kamata ka kasance da hankali idan wani yana amfani da maganinka ba tare da takardar magani ba ko rashin dacewa.

Kada ka taba yin maganin lorcaserin tare da kowa. Tsaya miyagun ƙwayoyi a wuri inda ba wanda zai iya samun shi.

Mene ne ya faru idan kun rasa rancen layin na Lorcaserin?

Kawai ɗaukar kashi da aka rasa a nan da nan ka tuna. Ya kamata ku yi tsai da kashi wanda aka rasa idan lokacin da za a shirya na gaba ya kusan. Kar ka ɗauki karin kashi don yin amfani da kashi wanda aka rasa.

Mene ne zai faru idan kun yi sama da na Lorcaserin?

Bincika don taimakon likita a gaggawa ko tuntuɓi layin taimakon taimakon Poison a 1-800-222-1222.

Menene ya kamata in kauce wa shan yayin da nake kan layi?

Kada ka ɗauki wani nauyin haɗari-nau'i ko nauyin kaya-ƙari-ƙari ba tare da shawarar likitanka ba. Har ila yau, kada ku dauki magunguna ko sanyi lokacin shan kwayar lorcaserin.

Waɗanne magunguna ne zasu iya shafar lorcaserin?

Wadannan magunguna zasu iya tasiri yadda yin amfani da lorcaserin:

  • Kyakkyawan '' '' '' '' 'wadanda ke da magungunan ciwon magunguna - irin su Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, da sauransu.
  • Cabergoline;
  • Daidaitawa;
  • kowane irin antidepressant
  • lithium;
  • Yoga na Yahaya;
  • dctfun dysfunctiondrugs- Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, da sauransu;
  • Tashi;
  • tryptophan (wanda aka sani da L-tryptophan);
  • maganin ko sanyi wanda ya ƙunshi dextromethorphan;
  • magunguna don magance cututtukan tunani, yanayi ko damuwa.

Jerin da aka sama ba cikakke bane. Wasu magunguna na iya shafar ƙwaƙwalwa, kuma ba duka halayen ma'amala ba an rubuta su a cikin wannan jagorar magani.

Rahotanni na BBC kan Tsaro da Kwarewa na Lorcaserin HCL (CAS 616202-92-7)

Akwai rahotanni da yawa na BBC kan Lorcaserin game da yadda ba a dace ba amma har ma lafiyar maganin. A cewar BBC, binciken da aka yi a kwanan nan, wanda aka wallafa a cikin New England Journal of Medicine, ya nuna mutane suna amfani da kwayar da ke cike da ciwon nama a cikin 8.8lb (4kg) a tsawon lokaci na tsawon shekaru uku da rabi. Sakamakon wannan binciken ya tabbatar da cewa lorcaserin ba shakka wani daga cikin kwayoyi masu asarar nauyi ba.

Rahoton ya kuma ce magani ne tun lokacin da yake aiki ta hanyar ragewa ci abinci, ba sa masu amfani a babban hadarin yanayin zuciya ba. Nazarin da aka wallafa ya biyo bayan wadanda suka kamu da cutar 12,000 a Amurka a cikin watanni 40.

Bayan shekaru uku da rabi, mazan da ke daukar karuwanci sun kasance sau uku fiye da kada su rage kashi biyar zuwa goma cikin dari na jikin su fiye da wadanda ke samun wuribo, in ji daya daga cikin masu bincike na binciken, Dr. Erin Bohula.

Gwaje-gwaje da aka gudanar a kan kwakwalwar zuciyar ba ta nuna alamun bambance-bambance ba idan aka kwatanta da ƙuƙwalwar zuciyar waɗanda suke ɗaukar wuri. Samun cewa wannan ya zama damuwa ta farko idan yazo ga lafiyar wasu kwayoyin kwayoyi, ƙwaƙwalwar ƙwaƙwalwa zai iya zama nauyi kwayar hasara mai kyau.

Manyan shan magani sun kasance a cikin ƙananan ƙwayar cutar ta 2. Kwayar kwayar tana kashe kimanin £ 155-225 ($ 220-290) a kowace wata a Amurka. Lorcaserin yana samar da kyakkyawar madaidaiciya ga halaye-raguwa kamar yadda ake yi a tsakanin wasu.

Wani rahoton BBC ya nuna wani binciken da masu bincike a Jami'ar Rowett ta Jami'ar Aberdeen suka gudanar da bincike game da ci. Masana kimiyya sunce cewa binciken da suka yi game da ci ya jagoranci su zuwa wani ɓangare na kwakwalwa.

Sun lura cewa ta hanyar rinjayar wadannan kwayoyin halitta da magungunan da suke iya rage abinci. Tun da yake lorcaserin ke aiki ne, wannan binciken ba wai kawai bude kofa don sababbin magunguna kamar lorcaserin amma kuma ya karfafa abin da masana suka yi imani game da lorcaserin-aminci da kuma ingancinsa.

BATSA DA TATTAUNAWA:

Ana Samun Wannan Abubuwan ne Don Amfani da Bincike Kawai. Sharuɗɗan Siyarwa suna Aiwatarwa. Ba don Amfani da Dan Adam bane, ko Likita, dabbobi, ko Amfani na Gida.


COA

HNMR

Mu ne masu samar da furotin na Lorcaserin, Belviq foda don sayarwa, (616202-92-7) hplc≥98% | HNMR mai sassaucin AASraw

AAS raw bayar da tsarki 98% Lorcaserin raw foda ga bodybuilders ko karkashin kasa labs don amfani da foda-asarar.

Recipes

Karin bayani & amsoshin samfurin

Lorcaserin foda: Dukkan abubuwa game da magungunan hasara

Rawanin Lafiya: Shin Lorcaserin foda yana aiki ne don hasara mai yawa?

20 abubuwan da suka fi muhimmanci Dole ne ku sani game da ƙwayar Lorcaserin HCL

Bibliography

  1. Weissman NJ, Sanchez M, Koch GG, et al. Kayan ƙwaƙwalwa na ƙwayar zuciya na valvular regurgitation tare da lorcaserin daga nazarin gwajin 3 na 3 gwaji. Xibiyar XML 2013; 6: 560-7
  2. Halford JC: Magunguna masu magungunan ƙwayoyi a ci gaba na asibiti. Curr Opin Investig Drugs. 2006 Apr; 7 (4): 312-8.
  3. Thomsen WJ, Grottick AJ, Menzaghi F, et al. Lorcaserin, wani littafi mai suna 5-hydroxytryptamine2C agonist: in vitro da halayyar kamfanoni da ke rayuwa. J Pharmacol Exp Ther 2008; 325: 577-87
  4. Smith BM, Smith JM, Tsai JH, et al. Sakamakon binciken da kuma tsarin tsarin aiki na Lorcaserin, mai maganin agu na mai daukar hoto na 5-HT2C na zafin jiki don magance kiba. J Med Chem 2008; 51: 305-13
  5. BBC News, "A Ƙananan ƙungiyar ƙwayoyin kwakwalwa zasu iya magance kiba kamar yadda masu binciken Aberdeen suka yi. "