Lorcaserin (Belviq) foda (616202-92-7) hplc≥98% | Asarar AASraw
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Lorcaserin (Belviq) foda

Rating: SKU: 616202-92-7. category:

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa tsari na murya na Lorcaserin (Belviq) foda (616202-92-7), a karkashin tsarin CGMP da tsarin kula da inganci mai kyau.

Samfur Description

 

Lorcaserin Gabatarwa

Samar da ƙwayar magungunan asarar lafiya da lafiya mai tsanani shine aiki mai wuyar gaske. Ƙoƙari a baya sun zo tare da tasiri masu yawa irin su lalacewar zuciya. Abin takaici, wani sabon binciken ya ce adadin kwayar hasara mai nauyi zai iya taimaka maka zubar da kisa ba tare da yin hadaya da lafiyar zuciyarka ba. Lorcaserin wata kwayar cutar ne mai cin gashin gaske, wadda FDA ta yarda a 2012. Amma abin da ke lorcaserin? To, a ƙasa ƙasa ne mai cikakken bayani game da maganin miyagun ƙwayoyi, tsarin da ya shafi sinadarai da kaddarorinsa, amfani, sashi, tsare-tsaren, da sauransu.

Sunan kamfanin: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Lorcaserin (Belviq) foda bidiyo

 

 


 

I.Lorcaserin (Belviq) foda ainihin Maballin:

 

name: Lorcaserin (Belviq) foda
CAS: 616202-92-7
Formula kwayoyin:  C11H14ClN
Kwayoyin Weight: 195.692
Shawarwar Melt: 212 ° C
Ajiye Temp: RT
Color: White zuwa kashe-farin foda

 


 

Lorcaserin Gabatarwa

Samar da ƙwayar magungunan asarar lafiya da lafiya mai tsanani shine aiki mai wuyar gaske. Ƙoƙari a baya sun zo tare da tasiri masu yawa irin su lalacewar zuciya. Abin takaici, wani sabon binciken ya ce adadin kwayar hasara mai nauyi zai iya taimaka maka zubar da kisa ba tare da yin hadaya da lafiyar zuciyarka ba. Lorcaserin wata kwayar cutar ne mai cin gashin gaske, wadda FDA ta yarda a 2012. Amma abin da ke lorcaserin? To, a ƙasa ƙasa ne mai cikakken bayani game da maganin miyagun ƙwayoyi, tsarin da ya shafi sinadarai da kaddarorinsa, amfani, sashi, tsare-tsaren, da sauransu.

Sunan kamfanin: Lorcaserin / BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

 

Da ke ƙasa akwai tsarin sunadarai na lorcaserin a cikin 3-D conformation.

Lorcaserin (Belviq) foda

 

Abubuwan Kayan Gida na Lorcaserin (belviq) (CAS 616202-92-7)

Da ke ƙasa akwai taƙaitaccen kayan haɗin sunadarai na Lorcaserin (belviq); an gabatar dasu a cikin tebur ɗin ƙasa don kallo da sauri.

 

Sunan Yanki Darajar Abinci
Ƙididdigar Ƙididdigar Ƙwararren Ƙidaya 1
Atomar Atom Count 0
Ba'a ƙayyade Bond Stereocenter Count ba 0
An ƙayyade Bond Stereocenter Count 0
Abubuwan da aka ƙayyade Atom Stereocenter Count 0
An tsara Atom Stereocenter Count 1
Tashin Atom Count 13
Dokar da ta dace 0
Kwararren Canonicalized Gaskiya
XLogP3-AA 2.7
Zama daidai 195.081 g / mol
Monoisotopic Mass 195.081 g / mol
Ƙungiyar Tashin Lafiya na Topological 12 A ^ 2
Hadaddiyar 172
Ƙididdigar Lissafin Rotatable 0
Hydrogen Bond Acceptor Count 1
Binciken Gida na Hydrogen Bond 1
kwayoyin Weight 195.69 g / mol
Ƙunƙasawar Maɗaukaki

 

pKa = 9.98 (est)

 

Bayani mai sauƙi na ƙwayar Lorcaserin HCL

Lorcaserin (Belviq) kwaya ne mai hana ci abinci wanda Arena Pharmaceuticals ya tsara. Yana daga cikin nau'ikan magungunan da ake kira agonists masu karɓar maganin serotonin. An tsara shi don taimaka muku jin ƙoshin bayan kun ɗan rage cin abinci. Yana dakile ci abinci ta hanyar kunna 5-HT2C masu karɓa, waxanda suke da nau'o'in masu karɓa na serotonin a cikin wani ɓangare na kwakwalwa (hypothalamus) wanda ke sarrafa ci. Lokacin da suke sigina jikinka don jin dadi, kayi cin abinci kadan, saboda haka ya ƙare nauyi a cikin lokaci mai tsawo.

Belviq, wanda sunansa na sunadaran (R) -8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate, ana nufin ana daukar shi ta bakin rai. Nauyin kwayoyinsa shine 241.16 g / mol, kuma maƙasudin mahimmanci shine C11H15Cl2N • 0.5H2O. Its tsarin tsari shine a nan:

 

Lorcaserin (Belviq) foda

 

Solarfin ruwan Lorcaserin hydrochloride hemihydrate a cikin ruwa ya fi 400 mg / mL. Allon Belviq yana da milligrams 10.4 na crystalline lorcaserin hydrochloride hemihydrate (fari zuwa fari-da fari), wanda yayi daidai da 10.0 milligram anhydrous lorcaserin hydrochloride. Shima yana dauke da wasu sinadarai, wadanda suka hada da magnesium stearate NF, talc USP, FD & C Blue # 2 tafkin aluminium, titanium dioxide USP, polyethylene glycol NF, polyvinyl alcohol USP, colloidal silicon dioxide NF, croscarmellose sodium NF, silicified microcrystalline cellulose da hydroxypropyl cellulose NF.

 

Ayyukan aikin gyaran na Lorcaserin

Bisa ga ka'idojin jagorancin Abinci da Drug Administration (2007), Lorcaserin na iya taimaka wa mazan girma wajen samun asarar asibiti. Wannan ƙwayar magungunan asarar ya ce ya yi aiki sosai a yayin da aka haɗa tare da ƙara yawan aikin jiki da kuma cin abinci maras calorie. Zai iya taimakawa wajen taimakawa tare da kulawa mai nauyi, musamman ma mutanen da suke da karba (akalla 27 kg / m2), ko obese (BMI na akalla30 kg / m2). Wannan magani zai iya taimaka wa waɗanda ke da nauyin abu guda ko fiye da nauyin, kamar su ciwon sukari na 2, dyslipidemia, ko hauhawar jini.

Lorcaserin wani nau'i ne mai cike da ciwon nama wanda ke aiki a matsayin 5-HT2C agonist mai karɓa a cikin hypothalamus tare da zaɓin aiki na sau goma sha biyar ƙarin dangantaka ga 5-HT2C  masu karɓa fiye da 5-HT2A  da kuma yin watsi da 100 sau da yawa don zaɓin aiki ga 5-HT2C masu karɓa fiye da na 5-HT2B.

Masu karɓar 5-HT2C suna kusan kusan a cikin kwakwalwar ɗan adam kuma ana iya samun su a cikin thalamus, hypothalamus, cortex, hippocampus, choroid plexus, cerebellum, da amygdala. Thearfafawar masu karɓa na 5-HT2C a cikin hypothalamus ya kunna samar da POMC (proopiomelanocortin) sabili da haka yana inganta rage nauyi ta cikin koshi. Wannan hujja tana tallafawa ta hanyar gwajin gwaji da sauran binciken bincike. Duk da yake yawanci ana tunanin cewa masu karɓar 5-HT2C suna taimakawa wajen tsara ci abinci, ɓoyewar ciki, da yanayi, ba a san ainihin yanayin aiki a ƙa'idar ci ba.

 

Receptor EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92

 

Amfani da launi na Lorcaserin HCL

Idan muka yi la'akari da ƙwallafin kirki na ainihi na Lorcaserin, to wannan shine tabbas mafi asarar nauyi a kasuwa a yau. Wasu mutane da yawa, watau, waɗanda ke da nauyin kiwon lafiyar da suke da nauyin nauyi ko wadanda suke da kariya suna iya amfani da wannan samfuri mai yawa.

Idan aka yi amfani da shi tare da shirin likita, likitancin calorie, da salon rayuwa, Lorcaserin zai iya taimakawa mutum yayi yawa fiye da rasa nauyi - zai iya taimakawa wajen rage yawan hadarin kiwon lafiya wanda ke hade da kiba, ciki harda hawan jini, ciwon sukari, cututtukan zuciya, da kuma mutuwar farko.

Bisa ga cibiyar Cibiyar Kula da Cututtuka, lalata 5 zuwa 10 kashi dari na nauyin jikin jiki zai iya gabatar da wasu sha'anin kiwon lafiya kamar gyaran jini, da cholesterol da jini, da kuma karfin jini.

 

 Sashin ilimin launi na Lorcaserin HCL

Dole ne a dauki magunguna biyu a kowace rana. Saboda haka kuna bukatar ɗaukar kwayoyin 60 kowace wata. A cewar FDA, ya kamata mutum ya yi amfani da miyagun ƙwayoyi yayin sauran rayuwarsa don kiyaye lafiyar lafiya.

Yana da mahimmanci a lura cewa an sami sakamako mai kyau bayan 12 makonni. Idan ba za ku rasa akalla 5 bisa dari na ma'aunin jikin ku ba, to, ana shawarce ku daina amfani da kwaya. Ko da ci gaba da yin amfani da shi, ba zai yiwu ba za ku iya cimmawa kuma ku ci gajiyar asarar asibiti.

 

Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Harkokin Ciki

Yana da kyau a tuna cewa ƙwararrun likitocin ku sun ba da wannan magani saboda sun yanke hukunci cewa fa'idar da kuka samu ya fi haɗarin haɗarin illa. Yawancin mutanen da ke shan wannan magani ba sa nuna sakamako mai illa.

Kafin ka ɗauki lorcaserin, bari likitan ka ko likitan ka su sani ko kana rashin lafiyan maganin; ko kuma kuna da wasu cututtukan. Lorcaserin yana dauke da sinadarai marasa aiki wadanda zasu iya haifar da halayen rashin lafiyan ko wasu batutuwa. Tambayi likitan ku don ya ba ku ƙarin bayani.

Kafin shan wannan magani, sanar da likitan ka ko likitanka game da tarihin lafiyar ka, musamman matsalolin koda, ciwon suga, matsalar hanta, cututtukan zuciya (gami da bugun zuciya, cututtukan bawul na zuciya, jinkirin bugun zuciya, gazawar zuciya) matsalolin da ke iya ƙara haɗarin mai raɗaɗi / tsawaitawa a cikin maza (gami da azzakari mara kyau, cutar Peyronie, myeloma da yawa, cutar sikila, cutar sankarar bargo).

Wannan kwayar maye mai cike da ci na iya sa ku rage tunani ko damuwa. Marijuana ko barasa na iya sa waɗannan tasirin su zama mafi muni. Kada ayi amfani da injina, tuƙi, ko aikata komai wanda ke buƙatar faɗakarwa har sai kun sami damar yin shi a hankali. Ayyade abubuwan shaye shaye kuma yi magana da likitanka idan kuna amfani da marijuana.

Idan za a yi maka aikin tiyata, yana da kyau ka gaya wa likitan hakori ko likita game da duk samfuran da ka sha (gami da magunguna marasa magani, kayan ganye, da magunguna).

Idan kana rayuwa da ciwon sukari, wannan kwaya mai nauyin nauyi na iya shafar jininka. Tabbatar da duba matakin sikarin jininku a lokaci-lokaci kamar yadda aka shawarta kuma raba sakamakonku tare da likita. Sanar da likitan ku idan kuna da alamun cutar sikari. Kwararrun likitocin ku na iya buƙatar daidaita shirin motsa jiki, abinci ko maganin ciwon sikari.

Dole ne a sha wannan magani a lokacin daukar ciki saboda yana iya cutar da jaririn da ba a haifa ba. Tambayi likitanku game da aikace-aikacen hanyoyin ingantaccen haihuwa. Idan kana da juna biyu ko kuma ka sami ciki, ka gaya wa malamin lafiyar ka nan da nan.

Ya zuwa yanzu, ba a san ko wannan magani ya shiga cikin nono ba. Don hana yiwuwar haɗari ga jariri, ba da shawarar nono lokacin amfani da wannan magani. Tabbatar cewa ka shawarci likitanka kafin ka shayar.

Karanta Bayanin Bayanai na Mai amfani a hankali idan akwai daga likitanka kafin ka fara amfani da lorcaserin kuma duk lokacin da zaka sami cikawa. Idan kana da wata tambaya, tambayi likitan ka ko likita.

Thisauki wannan kwaya mai hana cin abinci ta baki tare ko ba tare da cin abinci ba kamar yadda likitan magungunan ku ya umurta, yawanci sau biyu a kowace rana. Yi amfani da wannan magani akai-akai don samun fa'idarsa. Don taimaka maka ka tuna, ɗauki kwaya a lokaci ɗaya kowace rana.

Lorcaserin shine maganin miyagun ƙwayoyi. Kada ka ƙara yawan kashi ko ka dauki wannan kwaya fiye da yadda aka tsara. Yanayin da kake da shi bazai inganta kowane sauri ba, kuma hadarin illa na iya ƙara.

Hanyoyin maganin miyagun ƙwayoyi na iya faruwa a yayin da ake amfani da kwayoyi masu amfani tare da kwayar ƙwayar lorcaserin. Faɗa wa likitanku game da dukkanin kwayoyi da kuke amfani da su a halin yanzu, da kowane takardar sayan da kuka fara ko dakatar da yin amfani da su.

Ba a yarda da kwayar lalata kwayar cutar ta Magnetta ba don ba ta amfani da yara masu tsufa ba fiye da shekaru 18.

 

Yaya ya kamata in dauki murfin Lissafin Cizonal HCL?

Kada ku ƙyale, karya, ko kuɓutar da kwamfutar hannu mai ɗorewa. Kamar haɗiye shi duka.

Maimakon ciwon ciwon sikila ne kawai wani ɓangare na tsarin kulawa wanda ya kamata ya hada da motsa jiki, kula da nauyi, cin abinci, da kuma jarrabawar jinin ku kullum. Bi da maganin ku, abinci mai gina jiki, da kuma motsa jiki yana ci gaba sosai.

Ajiye magunguna a dakin da zazzabi daga zafi da damshi.

Tsaya rikodi na yawan kwayoyi da aka yi amfani da su daga dukan kwalabe. Labaran asarar ƙwayar murzarin ƙwayar kwayar cutar kwayoyi ne mai amfani da miyagun ƙwayoyi, kuma ya kamata ka kasance da hankali idan wani yana amfani da maganinka ba tare da takardar magani ba ko rashin dacewa.

Kada ka taba yin maganin lorcaserin tare da kowa. Tsaya miyagun ƙwayoyi a wuri inda ba wanda zai iya samun shi.

 

Mene ne ya faru idan kun rasa rancen layin na Lorcaserin?

Kawai ɗaukar kashi da aka rasa a nan da nan ka tuna. Ya kamata ku yi tsai da kashi wanda aka rasa idan lokacin da za a shirya na gaba ya kusan. Kar ka ɗauki karin kashi don yin amfani da kashi wanda aka rasa.

 

Mene ne zai faru idan kun yi sama da na Lorcaserin?

Bincika don taimakon likita a gaggawa ko tuntuɓi layin taimakon taimakon Poison a 1-800-222-1222.

 

Menene ya kamata in kauce wa shan yayin da nake kan layi?

Kada ka ɗauki wani nauyin haɗari-nau'i ko nauyin kaya-ƙari-ƙari ba tare da shawarar likitanka ba. Har ila yau, kada ku dauki magunguna ko sanyi lokacin shan kwayar lorcaserin.

 

Waɗanne magunguna ne zasu iya shafar lorcaserin?

Wadannan magunguna na iya shafar yadda lorcaserin ke aiki:

  • Wani "triptan" waɗanda sune magungunan ƙaura na ƙaura – kamar su Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan, zolmitriptan, Imitrex, da sauransu.
  • Cabergoline;
  • Daidaitawa;
  • kowane irin antidepressant
  • lithium;
  • John wort;
  • erectile dysfunctiondrugs– Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, da sauransu;
  • Tashi;
  • tryptophan (wanda aka sani da L-tryptophan);
  • tari ko kwayoyi masu sanyi wanda ya ƙunshi dextromethorphan; ko
  • magunguna don magance cututtukan ƙwaƙwalwa, yanayi ko damuwa.

Jerin da aka sama ba cikakke bane. Wasu magunguna na iya shafar ƙwaƙwalwa, kuma ba duka halayen ma'amala ba an rubuta su a cikin wannan jagorar magani.

 

Rahoton BBC Kan Tsaro da Ingancin Lorcaserin HCL (CAS 616202-92-7)

Akwai rahotanni da yawa na BBC kan Lorcaserin game da yadda ba a dace ba amma har ma lafiyar maganin. A cewar BBC, binciken da aka yi a kwanan nan, wanda aka wallafa a cikin New England Journal of Medicine, ya nuna mutane suna amfani da kwayar da ke cike da ciwon nama a cikin 8.8lb (4kg) a tsawon lokaci na tsawon shekaru uku da rabi. Sakamakon wannan binciken ya tabbatar da cewa lorcaserin ba shakka wani daga cikin kwayoyi masu asarar nauyi ba.

Rahoton ya kuma ce magani ne tun lokacin da yake aiki ta hanyar ragewa ci abinci, ba sa masu amfani a babban hadarin yanayin zuciya ba. Nazarin da aka wallafa ya biyo bayan wadanda suka kamu da cutar 12,000 a Amurka a cikin watanni 40.

Bayan shekaru uku da rabi, mazan da ke daukar karuwanci sun kasance sau uku fiye da kada su rage kashi biyar zuwa goma cikin dari na jikin su fiye da wadanda ke samun wuribo, in ji daya daga cikin masu bincike na binciken, Dr. Erin Bohula.

Gwaje-gwaje da aka gudanar a kan kwakwalwar zuciyar ba ta nuna alamun bambance-bambance ba idan aka kwatanta da ƙuƙwalwar zuciyar waɗanda suke ɗaukar wuri. Samun cewa wannan ya zama damuwa ta farko idan yazo ga lafiyar wasu kwayoyin kwayoyi, ƙwaƙwalwar ƙwaƙwalwa zai iya zama nauyi kwayar hasara mai kyau.

Manya masu shan magani suma suna cikin ƙananan haɗarin kamuwa da ciwon sukari na 2. Kwayar kwayar tana kashe kusan £ 155-225 ($ 220-290) a kowane wata a cikin Amurka. Lorcaserin yana ba da kyakkyawar madaidaiciya ga hanyoyin rage nauyi kamar na tiyata a cikin wasu.

Wani rahoton na BBC ya nuna wani bincike da masu bincike a Jami'ar Rowett ta Jami'ar Aberdeen suka gudanar da bincike kan ci abinci. Masana kimiyya sun ce binciken da suka yi kan ci ya kai su ga wani bangare na kwakwalwa.

Sun lura cewa ta hanyar rinjayar wadannan kwayoyin halitta da magungunan da suke iya rage abinci. Tun da yake lorcaserin ke aiki ne, wannan binciken ba wai kawai bude kofa don sababbin magunguna kamar lorcaserin amma kuma ya karfafa abin da masana suka yi imani game da lorcaserin-aminci da kuma ingancinsa.