Samfur Description
Menene Melanotan II?
Melanotan II (kuma ana kiranta da Melanotan 2,MT2,MT-2,MT-II) wani nau'in nau'in nau'in peptide ne da aka samar da shi ta hanyar halitta a cikin jiki wanda ke motsa melanogenesis, wani tsari da ke da alhakin canza launin fata.Alpha-Melanocyte Stimulating Hormone, wanda aka fi sani da MSH, yana aiki ta hanyar kunna takamaiman masu karɓar melanocortin don samar da tasirinsa.Hakika, ta hanyar waɗannan masu karɓa na melanocortin, MSH kuma yana da tasiri mai mahimmanci akan metabolism na lipid, yunwa, da jima'i. Sakamakon haka, bincike ya nuna cewa Melanotan 2 yana da tasirin da ya wuce kawai haɓaka fatar fata, kamar kashe yunwa, haɓaka lipolysis, da haɓaka sha'awar jima'i.Saboda ikon sa na motsa melanogenesis, Melanotan 2 an yi nazari sosai don aikace-aikacen don hana lalacewar tasirin UV daga hasken rana.
Ci gaban Melanotan 2
Halittar farko na Melanotan 2 peptide na roba za a iya ƙididdige shi ga Jami'ar Arizona. A yayin gudanar da bincike da nufin haɓaka kariya daga ciwon daji na fata, an mayar da hankali kan haɓaka hanyar haɓaka melanogenesis na halitta, ko kuma samar da melanin na halitta. Da farko, Jami'ar Arizona masu bincike sun yi yunƙurin sarrafa alpha-MSH da ke faruwa a cikin fata kai tsaye don samun wannan sakamakon da ake so. An ƙaddara cewa MSH da ke faruwa a zahiri yana da ɗan gajeren rabin rayuwa don zama mai amfani da gaske a matsayin magani na warkewa. Duk da haka, kyakkyawan sakamakon da aka samu daga gwamnatin MSH ya ƙarfafa ƙarin bincike game da ci gaban Melanotan 1 da Melanotan 2, waɗanda ke nuna irin wannan tasiri yayin da suke nuna irin wannan tasiri mallaki tsawon rabin rayuwa don amfanin aikin warkewa.
Menene Melanin?
Melanin shine launin fata da aka samar wanda ke kare fata daga hasken rana ta UV radiation da lalacewa. Ana iya la'akari da jikinmu na jikinmu na jikinmu. da kariya daga UV radiation yana nufin cewa waɗancan mutanen da ke da fata mai kyau suna da kusanci don ƙonawa da haɗarin ƙarin lalacewar DNA. Hakanan yana nufin cewa lokaci mai yawa ana kashe ikon su don haɓaka tan lafiya ba tare da konewa ba.
Samun isasshen isasshen bitamin D daga rana ba tare da kasancewa cikin haɗarin haɓakar melanoma ba ɗan aikin daidaitawa ne.Nazari sun riga sun gano cewa tsayawa daga rana don hana cutar melanoma na iya haifar da ƙarancin bitamin D. Kwayoyin pigment na fata da ake kira melanocytes.
Yaya Melanotan II ke aiki?
Melanotan II (MT2) yana aiki ta hanyar yin hulɗa tare da takamaiman masu karɓa a cikin jiki da ake kira melanocortin receptors. Ga rugujewar yadda Melanotan II ke aiki:
Daure ga masu karɓar melanocortin
Melanotan II yana ɗaure kuma yana kunna masu karɓar melanocortin, musamman MC1R da MC4R masu karɓa.Wadannan masu karɓa ana samun su da farko akan melanocytes, ƙwayoyin fata na musamman waɗanda ke da alhakin samar da melanin.
Ƙarfafa samar da melanin
Lokacin da Melanotan II ya ɗaure ga melanocortin receptors, yana haifar da jerin halayen biochemical a cikin melanocytes. Wannan haɓakawa yana haifar da haɓakar samar da melanin, pigment da ke da alhakin tantance fata, gashi, da launin ido.
Kunna hanyoyin melanin
Melanotan II yana kunna hanyoyin siginar da ke cikin melanogenesis, tsarin haɗin melanin. Wannan ya haɗa da hanyar adenosine monophosphate (cAMP), hanyar cyclic, wanda ke taka muhimmiyar rawa wajen daidaita samar da melanin da rarrabawa.
Ƙara yawan aikin melanocyte
Melanotan II yana haɓaka haɓakawa da aiki na melanocytes, yana haifar da haɓaka samar da melanin.Wannan yana haifar da duhun fata kuma yana iya kwaikwayi tasirin tanning na halitta.
Tasirin kariya ta rana
Ta hanyar haɓaka samar da melanin, Melanotan II na iya ba da ɗan kariya daga hasken UV.Melanin yana ɗaukar hasken UV, yana hana su shiga zurfi cikin yadudduka na fata da haifar da lalacewar DNA, kunar rana, da sauran illolin da ke tattare da wuce kima da fallasa rana.
Yana da mahimmanci a lura cewa tasiri da tsawon lokacin tasirin tanning na Melanotan II na iya bambanta tsakanin mutane saboda dalilai kamar kwayoyin halitta, sashi, da yawan amfani. Bugu da ƙari, yayin da Melanotan II na iya ba da wasu matakan kariya daga rana, ba madadin ba ne. don ingantattun matakan kariya daga rana, kamar saka garkuwar rana da iyakance hasken UV.
Melanotan II (MT2) fa'idodin peptide tanning
Melanotan II (MT2) yana da abubuwa na musamman da yawa waɗanda suka bambanta shi da sauran hanyoyin fata da fata. Ga wasu fitattun siffofi:
Ƙara yawan samar da melanin
Melanotan II an ƙera shi don tada samar da melanin, pigment da ke da alhakin fata, gashi, da launin ido. Wannan peptide yana ɗaure ga masu karɓar melanocortin, yana haifar da sakin melanin, wanda ke haifar da duhun fata.
Mai yuwuwar rage hasarar rana (Melanotan II don tanning)
Ɗaya daga cikin mahimman fa'idodin Melanotan II shine yuwuwar sa don rage yawan faɗuwar rana da ake buƙata don cimma tan. lalacewar fata.
Melanotan II yana ba da damar waɗanda ba su taɓa tanƙwara ba kuma suna ƙonewa a rana don samun tan na halitta.Synthetic melanotropin peptide supplements suna ba da damar canza rayuwa ga marasa lafiya tare da rashin lafiyar rana / masu karɓa. cewa fata mai kyau a yau za ta iya cimma. Melanotan an halicce shi tare da manufar rage yawan ciwon daji kuma watakila ya zama wakili na tanning maras amfani.
'Yan wasa da masu sha'awar motsa jiki suna amfani da Melanotan 2 don haɓakar tanning, haɓaka libido da hana ci abinci.Melanotan 2 an sanya shi da maganin Barbie kuma an haskaka shi a cikin mujallu na waya. Melanotan II ya ci gaba da kasancewa mafi inganci peptide tanning da ake siyar da shi akan layi.Don Allah a tabbata kun sayi MT2 daga Maƙerin peptide na gaske saboda samfurin da aka yi mara kyau na iya ɗaukar ƙarin haɗari.
Aikace-aikacen likita mai yiwuwa
Bayan tanning na kwaskwarima, Melanotan II yana nuna alkawari a wasu yanayi na likita. Misali, ana iya amfani da shi azaman zaɓin magani ga mutanen da ke da vitiligo, cuta ta fata wanda ke da faci na fata mai lalacewa. Bugu da ƙari, an yi nazari don yuwuwar tasiri a Sarrafa erythropoietic protoporphyria (EPP), cuta ce da ba kasafai ake gado ba wacce ke haifar da tsananin hankali ga hasken rana.
An ruwaito haɓaka libido
Wani al'amari mai ban sha'awa da ke hade da Melanotan 2 shine sakamakon da aka ruwaito akan libido da aikin jima'i. Wasu masu amfani sun ba da rahoton ƙara yawan sha'awar jima'i da sha'awar a matsayin sakamako mai tasiri na amfani da wannan peptide. Duk da haka, yana da mahimmanci a lura cewa waɗannan tasirin suna da ban mamaki kuma bazai yiwu ba. a dandana da duk masu amfani.
Melanotan II asarar nauyi
Duk da yake ba manufarsa ta farko ba, wasu nazarin sun nuna cewa Melanotan II na iya taimakawa wajen rage cin abinci da asarar nauyi. Duk da haka, ana buƙatar ƙarin bincike don fahimtar tasirinsa akan metabolism da tsarin nauyi.
Samfuran nau'in Melanotan II (MT2) a kasuwa
Akwai Melanotan II da yawa don siyarwa akan layi, samar da MT2 yana da girma.MT2 yana da samuwa a cikin maganin hanci, pre-mixed Melanotan 2, pills, melanotan na baki da alluran Melanotan II. Duk da haka, peptide Melanotan II (MT2) yana samuwa da farko. a cikin kasuwa a cikin nau'i na lyophilized foda don sake gyarawa da kuma gudanarwa na gaba.A nan ne mafi yawan nau'i na Melanotan II samuwa:
Foda foda
Melanotan II yawanci ana sayar da shi azaman lyophilized foda, wanda shine nau'i mai bushe-bushe na peptide.Yawanci ya zo a cikin vials ko ƙananan kwantena.Melanoan 2 mai ba da kaya AASRAW ba kawai yana ba da peptide foda ba kawai, amma kuma lyophilized foda a cikin vials.
Sake tsarin mulki
Kafin amfani, foda yana buƙatar sake ginawa tare da sauran ƙarfi mai dacewa, yawanci bakararre ruwa ko ruwan bacteriostatic. umarnin sake fasalin na iya bambanta dangane da takamaiman samfurin da masana'anta na MT2, don haka yana da mahimmanci a bi ka'idodin da aka bayar a hankali.
Inuwa
Da zarar an sake dawo da foda, Melanotan II yawanci ana gudanar da shi ta hanyar allurar subcutaneous. Ana amfani da ƙaramin allura don allurar maganin a ƙarƙashin fata, yawanci a cikin nama mai kitse na ciki ko cinya.Maimakon siyan allura a cikin ƙasa, shi ne. Ya tanadi kudi don siyan lyophilized foda na Melanotan 2 don yin alluran MT2 na kansu.Sai Melanotan 2 wholesale zai sami farashi mai kyau.
Yana da mahimmanci don tabbatar da inganci da halaccin samfurin lokacin siyan Melanotan II, saboda jabu ko sigar da ba ta dace ba na iya haifar da ƙarin haɗari.
Melanotan II Tasirin Side
Melanotan II peptide da aka ba da shi ta hanyar subcutaneously ana ba da rahoton lafiya kuma yana da inganci a cikin shawarar allurai.
Tashin zuciya
Ciwon ciki
rage ci
Hayaniya
Fatar duhu
Matsalolin azzakari cikin hanzari
Canji a cikin siffofin tawadar Allah
A cikin mafi munin yanayi, akwai yuwuwar haɗari ga waɗannan sakamako masu illa masu tsanani, gami da:
Wani nau'in ciwon daji na fata (melanoma)
Ƙirƙirar sababbin moles da melanocytic naevi na yau da kullun
Rhabdomyolysis (lalacewar ƙwayoyin tsoka wanda zai iya mutuwa)
Encephalopathy ciwo
Jima'i dysfunction
Yana da mahimmanci a fahimci cewa idan an raba allura ko kuma ba a tsaftace su da kyau kafin amfani da su, akwai haɗarin kamuwa da cuta.Kamar yadda kowane allura, ja da ciwo a wurin allurar zai yiwu.Sai kawai saya peptide melanotan II tare da tsabta na 98% ko mafi girma.
Ba a ba da shawarar yin amfani da allurar PT-141 a lokaci guda tare da mai hana PDE5 a cikin maza saboda haɗarin priapism.
Bai kamata a yi amfani da wannan samfurin ba idan kuna da ciki ko kuma mai shayarwa.Babu isassun shaidu don nuna yadda lafiya yake ga mutanen da ke cikin wannan rukunin.Kamar yadda yake tare da kowane magani, yakamata ku tuntuɓi ƙwararren likita koyaushe kafin fara duk wani kari. A wannan lokacin, ba a san hulɗar miyagun ƙwayoyi ba, amma yana da kyau a yi hankali fiye da yin hakuri.
Masu bincike masu sha'awar bincike na Melanotan 2 sakamako masu illa na iya zama masu sha'awar inda za su sayi wannan sinadari na bincike akan layi.
Rahoton Gwajin Melanotan II-HNMR
Menene HNMR kuma Menene Bakan HNMR ke gaya muku?H Nuclear Magnetic Resonance (NMR) spectroscopy dabara ce ta nazarin sinadarai da ake amfani da ita wajen sarrafa inganci da bincike don tantance abun ciki da tsarkin samfurin da kuma tsarinsa na kwayoyin halitta. Misali, NMR na iya tantance gaurayawan da ke dauke da sanannun mahadi. Don mahaɗan da ba a san su ba, NMR ana iya amfani da su ko dai don daidaitawa da ɗakunan karatu na bakan gizo ko don fahimtar ainihin tsarin kai tsaye. Da zarar an san ainihin tsarin, ana iya amfani da NMR don ƙayyade daidaituwar kwayoyin halitta a cikin bayani tare da nazarin kaddarorin jiki a matakin kwayoyin halitta kamar musanya mai daidaituwa, canje-canjen lokaci, solubility, da yadawa.
Yadda ake siyan Melanotan II daga AASraw?
❶Don tuntuɓar mu ta tsarin binciken imel ɗin mu, ko kuma ku bar mana lambar ku ta whatsapp, wakilin sabis na abokin ciniki (CSR) zai tuntuɓar ku cikin awanni 12.
❷Don samar mana da adadin ku da adireshin ku.
❸CSR ɗin mu zai ba ku fa'ida, lokacin biyan kuɗi, lambar bin diddigi, hanyoyin bayarwa da ƙididdigar ranar isowa (ETA).
❹An gama biyan kuɗi kuma za a fitar da kayan a cikin awanni 12.
❺Kayayyakin da aka karɓa kuma a ba da sharhi.
Marubucin wannan labarin:
Dr. Monique Hong ya sauke karatu daga Kwalejin Kimiyya ta Burtaniya ta London Faculty of Medicine
Mawallafin Jaridar Kimiyya:
1. Mariël P Ter Laak
Ma'aikatar Magungunan Magunguna, Rudolf Magnus Cibiyar Nazarin Neuroscience, Cibiyar Kiwon Lafiyar Jami'ar Utrecht
2. Chase W. Mallory BHS
Herbert Wertheim College of Medicine, Florida International University, Miami, FL, Amurka
3. Miia Kilpeläinen
Makarantar Pharmacy, Fasahar Magunguna, Jami'ar Gabashin Finland, Kuopio, Finland
4. Ryouichi Banno
Sashen Cututtukan Metabolic, Filin Magungunan Ciki, Makarantar Digiri na Jami'ar Nagoya, Japan
Babu wata hanya da wannan likita/masanin kimiyyar ya yarda ko ba da shawarar siyan, siyarwa, ko amfani da wannan samfur saboda kowane dalili. Aasraw ba shi da wata alaƙa ko alaƙa, a fayyace ko akasin haka, tare da wannan likitan. Manufar ambaton wannan likita shine yarda, yarda da kuma yaba da cikakken bincike da ayyukan ci gaba da masana kimiyyar da ke aiki akan wannan abu suka yi.
References
[1] Gilhooley E, Daly S, McKenna D.”Melanotan II Kwarewar Mai Amfani: Nazari Nazari na Dandalin Tattaunawa akan Layi.” Kimiyyar fata. 2021; 237 (6): 995-999. doi: 10.1159/000514492. Epub 2021 Agusta 31.PMID: 34464955
[2] Peters B, Hadimeri H, Wahlberg R, Afghahi H.” Melanotan II: mai yuwuwar sanadin ciwon koda: bitar wallafe-wallafe da rahoton shari’a.” Wakilin Case na CEN. doi: 2020/s9-2-159-z. Epub 161 Jan 10.1007.PMID: 13730
[3] Tomassi S, Dimmito MP, Cai M, D'Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S." CLIPSing Melanotan-II don Gano Mahalarta Zaɓaɓɓen HMCR Agonists. ”J Med Chem. 2022 Maris 10; 65 (5): 4007-4017. doi: 10.1021/acs.jmedchem.1c01848. Epub 2022 Fabrairu 21.PMID: 35188390
[4] Giuliano F, Clément P. 2006;138 (1): 293-301. doi: 10.1016/j.neuroscience.2005.11.008. Epub 2005 Dec 19.PMID: 16360286
[5] Hjuler KF, Lorentzen HF. "Melanoma hade da amfani da melanotan-II." Dermatology. 2014; 228 (1): 34-6. doi: 10.1159/000356389. Epub 2013 Dec 18.PMID: 24355990
[6] Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. masu karɓa." Am J Physiol Endocrinol Metab. 1 Satumba 2018;1(315):E3-E357. doi: 366/ajpendo.10.1152. Epub 00024.2018 Mayu 2018.PMID: 29
Sami babban zance
