Pregabalin foda

Pregabalin Foda Bidiyo-AAsraw

Raw Pregabalin Foda Basic Characters

Menene Pregabalin Powder?

Pregabalin foda shine maganin gabapentin-aji wanda ke aiki ta hanyar hana takamaiman tashoshi na calcium. Pregabalin An fara tsara foda don magance farfaɗo saboda tsarin aikinsa yana kama da na gabapentin, wanda zai iya hana kamuwa da cuta ta hanyar daidaita tashoshin calcium masu dogara da wutar lantarki a cikin tsarin kulawa na tsakiya. A gwajin asibiti, duk da haka, masu bincike sun gano cewa yana da inganci sosai. a cikin kula da ciwo. Pregabalin foda yana rage ciwon neuropathic, ciwon sukari na gefe neuropathy, da sauran alamun ta hanyar haɓakawa. Gaba matakan da ke cikin jiki da kuma kawar da sakin neurotransmitters mai ban sha'awa. Hakanan za'a iya amfani da foda na Pregabalin don magance yawan yanayin zafi, ciki har da fibromyalgia da neuralgia na postherpetic. A sakamakon haka, ana amfani da foda na pregabalin sosai a cikin maganin cututtuka daban-daban na ciwo kuma ya fito a matsayin magani mai mahimmanci a cikin maganin ciwon daji na neuropathic.

Ta yaya Pregabalin ke Aiki akan jiki?

Tsarin aikin Pregabalin yayi kama da na gabapentin, kuma ya nuna tasirin anticonvulsant da analgesic a yawancin nau'ikan dabbobi, kodayake ainihin tsarin aikin har yanzu ba a san shi ba. Pregabalin yayi kama da na GABA neurotransmitter, duk da haka baya aiki a cikin hanya ɗaya. Wannan maganin, duk da haka, ya bambanta da daidaitattun magungunan antiepileptic. A cikin kewayon maida hankali mai inganci, ba shi da wani tasiri akan masu karɓar GABAA ko GABAB. Ba a canza shi zuwa GABA ko GABA agonist, kuma baya hana GABA ɗauka da lalata, kuma baya yin aiki akan tashoshin sodium ko calcium, kuma baya rage sakin glutamate da ɗauka.

Pregabalin foda, a gefe guda, ba shi da alaƙa ga glutamic acid, GABA, ko sauran masu karɓar amino acid masu aiki, amma yana iya maye gurbin ɗaurin tagged GABA zuwa tashar calcium ion tashar 2 da masu karɓa da kuma hana tsarin juyayi na tsakiya. Subunit 2-protein na tashoshi na calcium masu dogara da wutar lantarki wanda ke hana shigowar calcium ion, yana rage sakin abubuwan neurotransmitters masu ban sha'awa irin su glutamate, norepinephrine, da abu P kuma yana tasiri GABAergic neurotransmission. Bugu da ƙari, pregabalin na iya haɓaka matakan GABA da yawa a cikin jiki, kuma ƙara yawan adadin pregabalin na iya ƙara haɓaka ayyukan glutamic acid decarboxylase.

Tarihin Amfani da Pregabalin Foda?

A cikin 1950s, masana kimiyya sun gano wani mai hana neurotransmitter wanda aka sani da gamma-aminobutyric acid, ko GABA a takaice. GABA neurotransmitter ne wanda ke aiki akan masu karɓar GABA a jikin ɗan adam. Mutane suna tunanin cewa ƙananan GABA na iya haifar da farfaɗiya, kuma GABA na iya kasancewa da alaƙa da zafi saboda tasirin hanawa. Gano GABA da kuma fayyace hanyoyin samar da magunguna ya haifar da samar da sabbin magungunan rigakafin cututtukan fata, wanda sanannen su shine pregabalin.

Pregabalin foda wani magani ne da ake amfani dashi don magance yanayi daban-daban, ciki har da ciwon sukari na gefe neuralgia, postherpetic neuralgia, fibromyalgia, da ciwon neuropathic daga raunin kashin baya a cikin manya, da sauransu. Tun lokacin da aka gano pregabalin, ana ci gaba da aiwatar da haɓakar sa da aikace-aikacen sa.

√ A watan Agusta 2003, Pfizer ya fara shigar da takardar neman rajista a Amurka.

√ A watan Disamba 2004, the Amurka FDA an amince da pregabalin don ciwon sukari na gefe neuralgia da postherpetic neuralgia.

√ A cikin watan Yuni 2005, an amince da pregabalin a matsayin ƙarin magani a cikin jiyya na ɓarna-farawa.

√ A cikin Yuni 2007, FDA ta Amurka ta amince da pregabalin a matsayin magani na farko don maganin ciwo na fibromyalgia.

√ A cikin Yuni 2012, FDA ta amince da pregabalin a matsayin magani na farko don magance neuralgia wanda ya haifar da rauni na kashin baya.

√ A cikin Maris 2019, an yi amfani da pregabalin bisa hukuma don maganin fibromyalgia a China.

Ya zuwa yanzu, an amince da pregabalin don maganin ciwon neuropathic a cikin fiye da kasashe 40 ciki har da Turai, Kanada, da Mexico.

Kodayake pregabalin foda yana da yawa a duk duniya, yana da mahimmanci a yi taka tsantsan yayin la'akari da siyan pregabalin kuma kawai saya daga tushe masu daraja. Yawancin masana'antun pregabalin da masu ba da kayayyaki suna da'awar suna ba da pregabalin tare da inganci mai kyau, amma ba duk foda na pregabalin ba ne na gaske. Siyan magunguna daga tushen da ba a tantance ba ko kasuwannin kan layi na iya zama haɗari kuma yana iya haifar da karɓar jabu ko samfuran marasa inganci.

Fa'idodin Amfani da Pregabalin Foda

Pregabalin foda magani ne mai mahimmanci wanda ke ba da fa'idodi da yawa ga mutanen da ke da yanayin kiwon lafiya daban-daban. Wasu daga cikin mafi yawan yanayi na yau da kullum wanda zai iya amfana daga amfani da AASraw pregabalin foda ciki har da ciwon sukari na gefe neuropathy, postherpetic neuralgia, epilepsy partially, fibromyalgia, neuropathic zafi, da kuma rashin jin daɗi na gaba ɗaya.

· Ciwon Ciwon Ciwon Jiki (DPN)

Ciwon sukari peripheral neuropathy (DPN) sakamako ne gama gari na nau'in 1 da nau'in ciwon sukari na 2, yana shafar kusan 30-40% na masu ciwon sukari. Alamomin wannan yanayin jijiya a hannaye da ƙafafu sun haɗa da ciwo, rauni, da rashin jin daɗi. Pregabalin foda shine magani na farko na DPN, yana ba da taimako mai mahimmanci yayin da yake magance cututtuka kamar damuwa da rashin barci. Ana buƙatar ƙarin bincike, duk da haka, don fahimtar gabaɗaya pregabalin shine tasirin warkewa akan damuwa da rikicewar bacci, da kuma gano waɗanne mutane ne zasu fi amfana da wannan magani.

· Postherpetic Neuralgia (PHN)

Postherpetic neuralgia (PHN) wani ciwo ne mai raɗaɗi mai raɗaɗi wanda zai iya tasowa bayan kamuwa da cutar ta herpes zoster kuma ya zama ruwan dare kamar yadda marasa lafiya suka tsufa. PHN na iya zama da wahala a bi da shi kuma akai-akai yana buƙatar amfani da magunguna da yawa don samun ragi mai ma'ana. Pregabalin foda shine mafi yawan magungunan kwanan nan da za a yarda da shi don PHN. Bayanai sun nuna inganci don rage jin zafi da rushewar barci da PHN ya haifar a cikin marasa lafiya da abin ya shafa. Kodayake babu kwatancen kai tsaye, pregabalin yayi kama da gabapentin da sauran magungunan layin farko don maganin PHN.

· Sashin farfadiya

An ba da lasisin Pregabalin foda kuma an sayar da maganin rigakafin cututtukan cututtuka don amfani da shi azaman haɗin gwiwa na farfadiya. Yana aiki a tashoshin calcium na presynaptic, yana daidaita sakin neurotransmitter a cikin CNS. Tsakanin tsakiya guda uku bazuwar, makafi biyu, gwaje-gwaje masu sarrafa wuribo waɗanda ke yin rajistar marasa lafiya tare da ɓarna na ɓarna na ɓarna sun nuna tasirin antiepileptic na pregabalin akan placebo, azaman jiyya na haɗin gwiwa, tare da 31-51% na marasa lafiya suna nuna raguwar 50% a cikin mitar kamawa.

· Fibromyalgia

Ana sa ran Pregabalin foda don rage ciwo na fibromyalgia ta hanyar iyakance haɓakawar haɓakar nociception ta hanyar tashar tashar calcium da kuma sakin neurotransmitter a cikin hanyar ciwo mai tasowa. Hakanan an nuna Pregabalin don rage matakan glutamate da glutamine a cikin insula na baya na marasa lafiya na fibromyalgia, yana tsoma baki tare da haɗin aikin sa zuwa cibiyar sadarwar yanayin tsoho.

Nazarin jijiyar jijiya (ONS) akan marasa lafiya na fibromyalgia suna nuna ƙarancin yanayin yanayin zafi. An nuna Pregabalin yana da tasiri akan saukowa da kewayawar zafi a cikin berayen da suka ji rauni; Don haka, pregabalin shine tasirin tsakiya na iya ba da gudummawa ga tasirin sa wajen magance fibromyalgia.

· Ciwon Neuropathic

Pregabalin foda ne mai ƙarfin lantarki-gated Ca2 + tashar antagonist wanda ke ɗaure kawai ga sashin alpha-2-delta don haifar da tasirin analgesic. Yana warkar da alamun bayyanar cututtuka na nau'in ciwon neuropathic da yawa kuma ya samo asali a cikin maganin jiyya na farko tare da babban aminci da inganci. An tabbatar da shi a cikin bincike na ainihi a cikin nau'ikan dabbobi masu yawa na ciwon neuropathic don zama masu amfani a cikin maganin cututtuka irin su allodynia da hyperalgesia.

· Ciwon Tashin Hankali (GAD)

Nazarin ya nuna cewa pregabalin yana da inganci akai-akai wajen magance matsalar tashin hankali (GAD). A cikin bita mai mahimmanci, bakwai daga cikin gwaje-gwajen da aka bazu da kuma sarrafawa guda takwas sun ba da rahoton raguwar ƙididdiga masu mahimmanci a cikin Hamilton Anxiety Rating Scale scores tare da pregabalin foda allurai daga 150-600 MG. A cikin wani binciken daban-daban wanda ya shafi marasa lafiya na GAD wadanda suka karbi maganin foda na pregabalin don makonni 12-24, abubuwan da suka faru na janyewar bayyanar cututtuka da sake dawowa da damuwa bayan dakatarwa ya ragu. Pregabalin foda kuma na iya zama zaɓin magani mai mahimmanci ga marasa lafiya tare da GAD waɗanda ba su amsa da kyau ga maganin antidepressant ba.

Tsanaki: Saboda ainihin ingancin pregabalin yana da alaƙa da ingancin samfurin, yana da mahimmanci don siyan foda mai inganci na pregabalin. Pregabalin raw foda mai samar da AASraw masana'antun da kuma samar da pregabalin raw foda tare da tsauraran matakan samarwa. Idan kuna buƙatar, AASraw's pregabalin foda shine zaɓi mai kyau.

Menene Illar Amfanin Pregabalin Powder?

Abubuwan da ke tattare da foda na pregabalin suna kama da na sauran masu juyayi na tsakiya. Mummunan halayen ƙwayoyi masu alaƙa da amfani da pregabalin sun haɗa da:

· Na kowa (> 10%):

Dizziness

Rashin hankali

· Na kowa (1-10%):

Binciken tsoro

diplopia

asar, sai murna

Rikici

Ƙara yawan ci da karuwar nauyi na gaba

· Badi (0.1-1%):

Hypoglycemia

Rash

Muscle cramps

Myalgia

Arthralgia

Thrombocytopenia

Tushen koda

Rigakafi: Idan illolin ba su ragu a hankali ko bace, a nemi likita cikin gaggawa. Bayan haka, da fatan za a tabbatar da siyan ingantattun samfuran don rage illa.

Sashi da Gudanarwa na Pregabalin Powder don Magana

Anan ga ginshiƙi na shawarar da aka ba da shawarar na pregabalin foda don yanayin kiwon lafiya daban-daban:

Tsanaki: Yana da mahimmanci a lura cewa waɗannan matakan jagorori ne na gabaɗaya kuma suna iya bambanta dangane da abubuwan mutum ɗaya, kamar shekaru, nauyi, da tarihin likita. Bugu da ƙari, ana iya buƙatar daidaita sashi na tsawon lokaci bisa la'akari da martanin mutum ga maganin da duk wani tasiri da zasu iya fuskanta. Yana da mahimmanci a tuntuɓi mai bada sabis na kiwon lafiya don ƙayyade adadin da ya dace don kowane takamaiman yanayin likita.

Inda zan saya Pregabalin Foda?

Pregabalin yana samuwa duka akan layi da layi, amma dole ne ku zaɓi masu siyar da ku a hankali don tabbatar da cewa kuna samun foda mai tsabta na pregabalin. Lokacin zabar mai sayarwa don pregabalin foda, akwai abubuwa masu mahimmanci da yawa don la'akari. Da farko, yana da mahimmanci don tabbatar da cewa mai siyarwar ya kasance sananne kuma amintacce. Nemo masu samar da kayayyaki suna da tarihin samar da samfurori masu inganci da ingantaccen sabis na abokin ciniki. Bugu da ƙari, ƙila kuna so kuyi la'akari da abubuwa kamar mafi ƙarancin oda, lokutan bayarwa, da zaɓuɓɓukan biyan kuɗi. A ƙarshe, yana da kyau a karanta bita da kuma neman shawarwari daga wasu abokan ciniki don samun ra'ayi game da sunan mai kaya da matakin gamsuwar abokin ciniki. Ta hanyar yin la'akari da waɗannan abubuwan, za ku iya zaɓar mai samar da foda na pregabalin wanda ya dace da bukatun ku kuma yana samar da samfurori da ayyuka masu inganci.

AASraw yana daya daga cikin sanannun masana'antun da masu samar da foda na pregabalin, wanda ya himmatu wajen samar da inganci mai inganci, mai tsabta pregabalin foda ga abokan ciniki a duk duniya. Bayan haka, AASraw yana da ƙungiyar ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararrun kuma don tabbatar da cewa duk samfuranmu sun dace da mafi girman ƙimar inganci da tsabta. Bugu da ƙari, AASraw yana amfani da fasaha mai mahimmanci da kayan aiki don kera pregabalin foda wanda ba shi da ƙazanta da ƙazanta. A ƙarshe, AASraw yana da ƙayyadaddun tsarin kula da inganci don tabbatar da cewa kowane nau'in foda na pregabalin an gwada shi sosai don tsabta da ƙarfi.

Raw Pregabalin foda Rahoton Gwajin-HNMR

Menene HNMR kuma Menene bakan HNMR ke gaya muku? H Nuclear Magnetic Resonance (NMR) spectroscopy dabara ce ta nazarin sinadarai da ake amfani da ita wajen sarrafa inganci da bincike don tantance abun ciki da tsarkin samfurin da kuma tsarinsa na kwayoyin halitta. Misali, NMR na iya tantance gaurayawan da ke dauke da sanannun mahadi. Don mahaɗan da ba a san su ba, NMR ana iya amfani da su ko dai don daidaitawa da ɗakunan karatu na bakan ko don fahimtar ainihin tsarin kai tsaye. Da zarar an san ainihin tsarin, ana iya amfani da NMR don ƙayyade daidaituwar kwayoyin halitta a cikin bayani tare da nazarin kaddarorin jiki a matakin kwayoyin halitta kamar musanya mai daidaituwa, canje-canjen lokaci, solubility, da yadawa..

Pregabalin Foda (148553-50-8) -COA

Pregabalin Foda (148553-50-8) -COA

Yadda za a saya Pregabalin Foda daga AASraw?

❶Don tuntuɓar mu ta tsarin binciken imel ɗin mu, ko kuma ku bar mana lambar ku ta whatsapp, wakilin sabis na abokin ciniki (CSR) zai tuntuɓar ku cikin awanni 12.

❷Don samar mana da adadin ku da adireshin ku.

❸CSR ɗin mu zai ba ku fa'ida, lokacin biyan kuɗi, lambar bin diddigi, hanyoyin bayarwa da ƙididdigar ranar isowa (ETA).

❹An gama biyan kuɗi kuma za a aika da kayan a cikin awanni 12.

❺Kayan da aka karɓa kuma a ba da sharhi.

Marubucin wannan labarin:
Dr. Monique Hong ya sauke karatu daga Kwalejin Kimiyya ta Burtaniya ta London Faculty of Medicine

Mawallafin Jaridar Kimiyya:
1. Alexandra M. Stein
Orthopedics department, Hôpital Cochin Paris, 27, rue du Faubourg Saint-Jacques, 75014 Paris, France
2. Tomoya Akashi
Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
3. H.R. Martínez
Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey N.L., Mexico
4. Markus Dold
4.Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
Babu wata hanya da wannan likita/masanin kimiyyar ya yarda ko ba da shawarar siyan, siyarwa, ko amfani da wannan samfur saboda kowane dalili. Aasraw ba shi da wata alaƙa ko alaƙa, a fayyace ko akasin haka, tare da wannan likitan. Manufar ambaton wannan likita shine yarda, yarda da kuma yaba da cikakken bincike da ayyukan ci gaba da masana kimiyyar da ke aiki akan wannan abu suka yi.

reference

[1] MC Walker, JW Sander. Wahala wajen fitar da bayanan gwaji na asibiti zuwa aikin asibiti: batun magungunan rigakafin cututtuka. Neurology, 49 (1997), shafi na 333-337

[2] M.J. Field, R.J. Oles, L. Singh. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. Br J Pharmacol, 132 (2001), pp. 1-4

[3] Hong JS, Atkinson LZ, Al-Juffali N, Awad A, Geddes JR, Tunbridge EM, et al. (Maris 2022). "Gabapentin da pregabalin a cikin rikice-rikice na bipolar, jihohin damuwa, da rashin barci: nazari na yau da kullum, meta-bincike, da ma'ana". Ilimin Halin Halitta. 27 (3): 1339-1349.

[4] Freynhagen R, Baron R, Kawaguchi Y, Malik RA, Martire DL, Parsons B, et al. (Janairu 2021). "Pregabalin don ciwon neuropathic a cikin saitunan kulawa na farko: shawarwari don dosing da titration". Likitan Digiri na gaba. Informa UK Limited girma 133 (1): 1–9.

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