TAK-438 foda (1260141-27-2) foda - Maƙerin Maƙerin Masana'antu
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TAK-438

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TAK438, wanda aka fi sani da Vonoprazan Fumarate, sabon magani ne don magance cututtukan da ke da alaƙa da acid tare da wani sabon tsarin aikin da ake kira masu hana ƙwanƙwasa acid (P-CABs) wanda gasa ke hana ɗaurin ions potassium zuwa H +, K + -ATPase ( wanda aka fi sani da proton pump) a matakin ƙarshe na ɓoye ruwan ciki a cikin ƙwayoyin kayan ciki, yana sarrafa ɓoyayyen ruwan ciki. Yana bayar da ƙarfi mai ɗorewa da ɓoye tasirin sakamako mai hana ruwa.

Samfur Description

Abubuwa Na Asali

Product Name TAK-438 foda
CAS Number 1260141-27-2
kwayoyin Formula C21H20FN3O6S
Formula Weight 461.46
nufin abu ɗaya ne Vonoprazan Fumarate;
TAK-438 foda;
1260141-27-2;
Vonoprazan fumurate;
TAK438.
Appearance White zuwa kashe-farin foda
Ajiye da kulawa Dry, duhu kuma a 0 - 4 C don gajere (kwanaki zuwa makonni) ko -20 C na dogon lokaci (watanni zuwa shekaru).

 

TAK-438 foda Bayani

TAK438, wanda aka fi sani da Vonoprazan Fumarate, sabon magani ne don magance cututtukan da ke da alaƙa da acid tare da wani sabon tsarin aikin da ake kira masu hana ƙwanƙwasa acid (P-CABs) wanda gasa ke hana ɗaurin ions potassium zuwa H +, K + -ATPase ( wanda aka fi sani da proton pump) a matakin ƙarshe na ɓoye ruwan ciki a cikin ƙwayoyin kayan ciki, yana sarrafa ɓoyayyen ruwan ciki. Yana bayar da ƙarfi mai ɗorewa da ɓoye tasirin sakamako mai hana ruwa.

A cikin ƙwayoyin cuta na al'ada, TAK-438 maganin foda ya haifar da ƙarancin ƙarfin haɓakar acid. Sakamakon hanawa na TAK-438 foda akan ɓoyewar acid kamar yana da alaƙa da ilimin kimiyyar lissafi na ciki.

 

TAK-438 foda Kayan aikin

TAK-438 foda (Vonoprazan fumarate) abu ne mai banbanci kuma mai hana acid-gasa mai hana gasa (P-CAB) wanda ke gasa ya toshe gidan mai dauke da sinadarin potassium na H (+), K (+) - ATPase, maɓallin enzyme a cikin aiwatar da ƙwayar ciki na ciki Compoundungiyar zata iya tarawa a cikin yanayin acid kuma yakamata ya bada tsawon lokaci na hanawa saboda pKa alkaline na 9.06.

A cikin ƙwayoyin cuta na al'ada, TAK-438 maganin foda ya haifar da ƙarancin ƙarfin haɓakar acid. Sakamakon hanawa na TAK-438 foda akan ɓoyewar acid kamar yana da alaƙa da ilimin kimiyyar lissafi na ciki.

 

TAK-438 foda Aikace-aikace

TAK-438 foda (Vonoprazan fumarate ko Vonoprazan) sabon magani ne don magance cututtukan da ke da alaƙa da acid tare da wani sabon tsarin aikin da ake kira masu tokawar acid na gasa (P-CABs) wanda gasa ke hana ɗaurin ions potassium zuwa H +, K + - ATPase (wanda aka fi sani da proton pump) a mataki na ƙarshe na ɓoye ruwan ciki a cikin ƙwayoyin parietal na ciki. An amince da maganin a Japan don magance cututtukan da suka shafi acid, ciki har da gyambon ciki, duodenal ulcer, reflux esophagitis da Adjunct zuwa kawar da Helicobacter pylori game da batun Helicobacter pylori gastritis.

 

TAK-438 foda Gurbin & Gargadi

Hanyoyi masu illa na kowa sun haɗa da:

▪ gudawa,

▪ tashin zuciya da amai,

▪ maƙarƙashiya,

Pain ciwon ciki,

Rash fatawar fata,

B ciwon zuciya.

 

Waɗannan ba duk sakamakon tasirin TAK438 bane. Don ƙarin bayani, tambayi likitan ku ko likitan magunguna. Kira likitan ku don shawara na likita game da sakamako masu illa. Kuna iya bayar da rahoton sakamako masu illa ga FDA a 1-800-FDA-1088.

 

reference

[1] Arikawa Y, Nishida H, Kurasawa O, Hasuoka A, Hirase K, Inatomi N, Hori Y, Matsukawa J, Imanishi A, Kondo M, Tarui N, Hamada T, Takagi T, Takeuchi T, Kajino M. Ganowar sabon littafin pyrrole wanda ya samo asali 1- [5- (2-fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e fumarate (TAK-438 foda) azaman gasar potassium mai toshe acid (P-CAB) J Med Chem. 2012 Mayu 10; 55 (9): 4446-56. Doi: 10.1021 / jm300318t. Epub 2012 Apr 30. PubMed PMID: 22512618.

[2] Kondo M, Kawamoto M, Hasuoka A, Kajino M, Inatomi N, Tarui N. Nunin yawan kayan aiki na masu hana acid-gasa masu hana gasa. J Allon allo. 2012 Feb; 17 (2): 177-82. Doi: 10.1177 / 1087057111421004. Epub 2011 Sep 22. PubMed PMID: 21940711.

[3] Shin JM, Inatomi N, Munson K, Strugatsky D, Tokhtaeva E, Vagin O, Sachs G. Halin fasalin ɗan littafin mai cike gasa na acid mai hana ciki na ciki, H, K-ATPase, 1- [5- (2- fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 foda). J Pharmacol Mai Magana. 2011 Nuwamba; 339 (2): 412-20. Doi: 10.1124 / jpet.111.185314. Epub 2011 Aug 9. PubMed PMID: 21828261; PubMed Tsakiyar PMCID: PMC3199995.

[4] Hori Y, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. Nazarin da ke kwatanta tasirin antisecretory na TAK-438 foda, wani sabon labari mai hana acid-gasa acid, tare da lansoprazole a cikin dabbobi. J Pharmacol Mai Magana. 2011 Jun; 337 (3): 797-804. Doi: 10.1124 / jpet.111.179556. Epub 2011 Mar 16. An buga PMID: 21411494.

[5] Matsukawa J, Hori Y, Nishida H, Kajino M, Inatomi N. Nazarin kwatankwacin yadda ake aiwatar da hodar TAK-438, wani sabon littafin toshe mai ƙwanƙwasa acid, da lansoprazole a cikin ƙwayoyin cutar zomo na farko. Biochem Pharmacol. 2011 Mayu 1; 81 (9): 1145-51. Doi: 10.1016 / j.bcp.2011.02.009. Epub 2011 Mar 1. PubMed PMID: 21371447.

[6] Hori Y, Imanishi A, Matsukawa J, Tsukimi Y, Nishida H, Arikawa Y, Hirase K, Kajino M, Inatomi N. 1- [5- (2-Fluorophenyl) -1- (pyridin-3-ylsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamin e monofumarate (TAK-438 foda), wani labari da kuma mai ƙarfi mai hana acid-gasa don maganin cututtukan da suka shafi acid. J Pharmacol Mai Magana. 2010 Oktoba; 335 (1): 231-8. Doi: 10.1124 / jpet.110.170274. Epub 2010 Jul 12. An buga PMID: 20624992.