URB597

AASraw yana tare da kira da kuma samar da samfurin daga gram zuwa umurnin taro na URB597 (546141-08-6), a ƙarƙashin tsarin CGMP da tsarin kula da kyawawan dabi'u.

URB597, wanda aka fi sani da KDS-4103, yana da mahimmanci kuma mai zaɓaɓɓiyar mai amfani da fatty-acid amide hydrolase (FAAH), wani enzyme wanda ke haifar da hydrolysis intracellular endocannabinoid anandamide, tare da darajar 50% zubar da hankali IC50 na 4.6 nM da 0.5 nM a cikin ƙwayar kwakwalwa da kuma jikin hanta microsomes daidai da bi. URB597 yana nuna anxiolytic, antidepressant, antinociceptive da kuma analgesic effects a vivo ba tare da cinye wasu bayyanar cututtuka hade da cannabinoid-kamar mahadi.

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Samfur Description

URB597 bidiyo


I.URB597 na ainihi Abubuwa:

name: URB597
CAS: 546141-08-6
Tsarki: ≥99% (HPLC)
Tsarin kwayoyin halitta: C20H22N2O3
Girman kwayoyin halitta: 338.4
EINECS: 1312995-182-4
Kamancin: N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [1,1'-biphenyl] -3-yl ester; 3'-CarbaMoyl- [1,1'-biphenyl] -3-yl cyclohexylcarbaMate; 3- (3-carbaMoylphenyl) phenyl N-cyclohexylcarbaMate ; CarbaMic acid, N-cyclohexyl-, 3 '- (aMinocarbonyl) [1,1'-biphenyl] -3-yl ester; KDS 4103 N-Cyclohexylcarbamic acid 3' - (aminocarbonyl) [1,1'-biphenyl] -3-yl ester N-Cyclohexylcarbamic acid 3 '- (aminocarbonyl) [1,1'-biphenyl] -3-yl ester URB 597 KDS 4103; URB 597,> = 98%; APD597 (URB597)
Shawarwar Melt: 155-157 ° C
Alpha: D + 5 ° (c = 0.437 a chloroform)
Ajiye Temp: 2-8 ° C
Solubility DMSO: Soluble2mg / ML, bayyane (warmed)
Color: White m


II. URB597 amfani a sake zagayowar:

1.Name:

URB597

2.Howene aikin na URB597?

Rationale: Babban damuwa na asibiti tare da yin amfani da mai karɓa na 1 (CB1) mai karɓa na cannabinoid shine cewa wadannan mahalli sun kara yawan shan giya da kuma halayyar miyagun ƙwayoyi. A matsayin madaidaicin hanya, za a iya taimakawa aikin watsa labarai na CB1-receptor ta hanyar ƙara matakan anandamide tare da amfani da hydrolase fatty acid amide hydrohibitors (FAAH) inhibitors. Manufar: Amfani da mai sarrafawa na FAAH URB597, mun binciki ko kunna cannabinoid ƙararrawa yana kara yawan abin da ake amfani da shi a bara, kamar yadda abin ya faru da magunguna na CB1. Abubuwa da hanyoyi: An gwada URB597 a kan barazanar shan barasa a cikin ratsan Wistar da kuma shan barazanar shan giya a madarar da aka zabi Marcigian Sardinian alcohol-preferring (msP) rats. A cikin ratsan Wistar, hankalin URB597 a kan barasa-ya haifar da damuwa da kuma danniya - da kuma yohimbine- da kuma sake shigar da barasa da ake bukata. Don kwatanta, an gwada sakamakon gwajin CB1 antagonist rimonabant a kan ethanol kai-gwamnati. Sakamako: A ƙarƙashin yanayin gwaji, gwamnatin intraperitoneal (IP) ta URB597 (0.0, 0.3 da 1.0 mg / kg) kuma ba ta ƙara yawan kayan shan giya ba a madogarar raguwa ko kuma ba a daidaita tsarin 1 ba. A cikin gwaje-gwaje na sake dawowa, fili bai da tasiri a kan lakabi, damuwa da damuwa - da sake komawa daga yaduban. A wata hanya, URB597 ta soke dukkanin amsawar da ake ciki a lokacin janyewar bayan wani babban tsarin IP na barasa (3.0 g / kg). Rimonabant (0.0, 0.3, 1.0 da 3.0 MG / kg) na rage ma'anar sararin samaniya na ethanol. Sakamakon: Sakamako ya nuna cewa kunna aikin endocannabinoid anandamide ta hanyar zabi na hana FAAH bai kara yawan hatsarin shan barasa ba amma yana rage damuwa da ya shafi maye gurbin shan barasa. Hakazalika zamu iya kwatanta cewa magani bisa tushen amfani da masu amfani da tsarin endocannabinoid kamar URB597 na iya bayar da basira mai mahimmanci idan aka kwatanta da magani tare da masu sauyawa masu karɓa na CB1.

3.Ina tasiri URB597?

Hakanan URB 597 kadai kuma a hade tare da anandamide an gudanar da binciken a cikin rukuni daya na birai (n = 4) wanda ya nuna bambancin Δ9-THC (0.1 mg · kg-1 iv) daga abin hawa, kuma a wani rukuni (n = 5) Δ9-THC na yau da kullum (1 mg · kg-112 h-1 sc) wanda ya nuna bambanci ga rnonabant antagonist cannabinoid (1 mg · kg-1 iv).

4.Further umarnin:

URB 597 ya bunkasa yanayin halayen anandamide amma ba ma sauran CB1 agonists ba. Duk da haka, URB 597 bai inganta ingantaccen gyaran Δ9-THC ba wanda ya haifar da anandamide. Gaba ɗaya, waɗannan bayanai sun nuna cewa anandamide mai ban tsoro a cikin kwakwalwar kwakwalwa ba zai iya fahimtar halin halayen da ake gudanarwa ba.

Mai iya amfani da magungunan fatty acid amide na (FAAH) (IC50 dabi'u ne 3 da 5 nM a cikin hanta da kuma kwakwalwar ƙira). Ba a nuna wani abu mai mahimmanci ba game da wasu masu karɓa, tashar tashoshi da enzymes, ciki har da masu karɓa na cannabinoid dan adam da kuma ratsa monoacylglycerol lipase. Nuna aikin maganin antiallodynic da antihyperalgesic a cikin wani zane mai zafi na ƙura. A cikin vitro, KDS-4103 ya hana aikin FAAH tare da ƙananan magunguna (IC (50)) na 5 nM a cikin kwakwalwa ta kwakwalwa da kuma 3 nM a cikin ƙananan ƙwayoyin hanta. A cikin vivo, KDS-4103 inhibits kwakwalwa kwakwalwa FAAH aiki bayan gwamnatin intraperitoneal (ip) tare da kashi na miyagun kwayoyi (ID (50)) na 0.15 mg / kg. Cibiyar ba ta hulɗar da wasu cibiyoyin da aka danganta da cannabinoid, ciki har da masu karɓa na cannabinoid da kuma anandamide sufuri, ko kuma tare da babban sakon masu karɓa, tashoshin tashar jiragen ruwa, masu fashewa da kuma enzymes. Ta hanyar tsundar jita-jita zuwa ratsi da kumbuna KDS-4103 yana haifar da muhimmancin sakamako, irin na antidepressant-like da analgesic, wanda aka hana ta jiyya tare da masu karɓar mai karɓar CB1. Ya bambanta, a cikin allurai da ke da ikon hana aikin FAAH kuma ya haifar da matakan anandamide kwakwalwa, KDS-4103 ba ta yada tasirin maganin cannabinoid na gargajiya (misali, catalepsy, hypothermia, hyperphagia), baya haifar da zaɓi na wuri, kuma baya samar da jituwa akan sakamakon bayyanar da mai aiki na cannabis, Delta9-tetrahydrocannabinol (Delta9-THC). Wadannan binciken sun nuna cewa KDS-4103 na aiki ne ta hanyar inganta kayan aiki na anandamide a kan wani ɓangare na masu karɓar CB (1), wanda zai iya kasancewa a cikin sarrafa iko da motsa jiki. KDS-4103 yana samuwa a cikin ratsi da cynomolgus birai. Nazarin nazarin karatun da aka yi maimaitawa (1,500 mg / kg, kowace os) a cikin wadannan jinsunan biyu ba su nuna rashin ciwo ba. Bugu da ƙari, ba a nuna damuwa a gwaje-gwajen cytotoxicity na kwayan cuta ba a cikin gwajin Ames. Bugu da ƙari, ba a lura da raunuka a cikin ratsi a kan gwajin rotarod bayan shan magani mai tsauri tare da KDS-4103 a cikin allurai har zuwa 5 mg / kg ko a cikin baturin lura da aiki bayan maganin maganganu har zuwa 1,500 mg / kg. Sakamakon ya nuna cewa KDS-4103 zai ba da matsala mai kyau tare da magungunan jin dadi don magance tashin hankali, damuwa da zafi.

5. URB597:

Min umarni 10grams.
Za'a iya aika da binciken akan al'ada yawa (A cikin 1kg) a cikin 12 hours bayan biya.
Don yin umurni mafi girma (A cikin 1kg) za'a iya aikawa a cikin 3 workdays bayan biya.

6. URB597 Recipes:

Don bincika Abokin Abokan Abokin ciniki (CSR) don cikakkun bayanai, don bayaninku.

7. URB597 Marketing:

Da za a bayar da shi a nan gaba.


III. URB597 HNMR

Mu ne mai kwakwalwan foda, Fayaccen foda don sayarwa, Raw Aprepitant foda (170729-80-3) hplc ma98% | AASraw R & D masu amsa


IV. Yadda za'a saya URB597 daga AASraw?

1.To tuntube mu ta hanyar imel ɗinmutsarin bincike, ko skypewakilin sabis na abokin ciniki (CSR).
2.To samar mana da tambaya da adireshinka.
3.Our CSR zai ba ka zance, lokacin biya, lambar ƙididdiga, hanyoyin bayardawa da kuma kwanan wata zuwa ranar da aka zo (ETA).
4.Bayayyar da aka yi kuma za'a fitar da kayayyaki a cikin 12 hours (Domin a cikin 10kg).
5.Goods samu da bada comments.


Ganin shafukan samfurinka da kafi so:

Yadda ake amfani da Clenbuterol don asarar nauyi Mene ne nandrolone foda amfani da / nandrolone amfani?


Karin bayani game da samfurori masu dacewa,maraba don danna nan.


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