Magungunan anabolic steroids, jima'i na jima'i, SARMS, asarar hasara,
AASraw yana samar da NMN da NRC foda a cikin girma!

Urolithin A Backgroud

Amfanin zuciyar Rumman ya sa masu bincike suka binciko ta wace hanya wannan jan itacen zai ba mu lafiya. A cikin binciken da suka yi na baya-bayan nan, masu binciken na Switzerland sun gano wata sabuwar kwayar halitta wacce ta samo asali daga narkar da wasu mahadi biyu da aka samu a cikin rumman: punicalagins da ellagitannins. Wannan kwayar halitta ta musamman, wanda aka fi sani da urolithin A, yana taimakawa sake sabunta mitochondria, gidajen wutar lantarkinmu. Urolithin A yana buɗe ƙofar don sababbin sababbin hanyoyin maganin warkewa game da rikice-rikicen shekaru, gami da ƙarancin ƙarfi, wanda shine haɗarin haɗari ga nakasa, asibiti, da mace-mace.

Urolithin Bayani

Urolithin A shine mahaɗan ƙwayar cuta, wanda ke cikin rukunin mahaɗan ƙwayoyin cuta waɗanda aka sani da benzo-coumarins. Samfurin ƙarshe ne wanda aka samar daga amfani da abinci wanda ya ƙunshi ellagitannins (polyphenols) kuma ƙwayoyin ƙwayoyin jiki ne ke sarrafa shi. A takaice dai, ana samar da Urolithin A lokacin da mutum ya shayar da kayan abinci dauke da ellagitannins.

Urolithin A ba ya faruwa ta dabi'a a cikin ƙarshen ƙarshensa. Tushen abinci na Ellagitannin, kamar wasu nau'ikan 'ya'yan itace da ruman, dole ne a haɗa su da ƙwayoyin hanji don ƙirƙirar su. Domin mahaɗan su sami ingantattun aikace-aikace, dole ne a kera shi a cikin lab, ko kuma a wata ma'anar, dole ne a samar da Urolithin A ta roba don ana iya amfani da shi.

Nazarin ilimin kimiyya ya nuna cewa Urolithin A ya mallaki kayan tsufa. An ce yana taimakawa cikin haɓakar ƙwayar tsoka, yana da kayan haɗin anti-inflammatory, har ma ya nuna ƙwarewa wajen inganta lafiyar hankali ga tsofaffi.

Urolithin Hanyar Ayyuka

Ta yaya Urolithin A ke aiki? Ellagic acid da Ellagitannins sune masu gabatarwa Urolithin A.

Ellagitannins ana yin su da ruwa daga hanji zuwa fitowar Ellagic acid, kuma ana sarrafa wannan ne daga hanji microflora zuwa urolithins ta hanyar karin asara a cikin 1 na lactones dinsa biyu na cire hydroxyl. Da zarar an shanye shi a cikin hanjin, to Urolithin A foda ya shiga cikin kwararar Tsarin wannan hanjin.

Mitophagy, bisa ga ma'anar Wikipedia, shine zaɓin lalacewar mitochondria ta hanyar aikin autophagy. Yana faruwa sau da yawa ga mitochondria mai lahani bayan lalacewa ko damuwa. Koyaya, yayin da muke tsufa, aikin Mitophagy yana zama mai ƙarancin aiki. Abin farin ciki, Urolithin A an yarda dashi don motsa mitophagy ta hanyar kiyayewa ta kowane nau'in.

Fa'idodi / Tasirin Urolithin A

Rol Urolithin A Yana Taimakawa Akan Ciwon Sankara

Duk da matsanancin aikin tiyata da kuma cutar sankara, kusan 50% na mutanen da ke fama da cutar kansa suna haifar da ciwace-ciwace. Wannan na iya kasancewa saboda wani ɓangare na rayuwar ƙwayoyin cuta masu hana kamuwa da hanji wanda ke tsayayya da maganin gargajiya da kuma aiki a matsayin '' tsaba '' don cututtukan da ke tafe.6
A cikin bincike mai ban sha'awa, masu bincike sun fallasa kwaya-kwayar cutar kanjamau daga mai haƙuri tare da ciwon sankarar fata zuwa gauraya mai ɗauke da 85% urolithin A ko 30% urolithin A. Sakamakon ya kasance mai ban sha'awa. Cikakken urolithin Cakudawar haɗuwa ya kasance mafi tasiri wajen hana lamba da girman ƙwayoyin cuta na kansar hanji da kuma hana aikin aldehyde dehydrogenase, alama ce ta ƙarfin gwiwa.
Wannan tsarin maganin yana da ban sha'awa saboda hanyoyin gargajiya na yaki da cutar kansa basu da ikon kashewa ko dakatar da yaduwar kwayar cutar kansa. Waɗannan sababbin binciken suna tallafawa ra'ayin cewa tsarin abinci mai gina jiki na iya tabbatar da mahimmanci azaman madadin magani ko rigakafin rigakafi don ƙaddamar da waɗannan ƙwayoyin cutarwa.

Rol Urolithin A - Tasirin Neuroprotective

Haɗin tsakanin rumman da tasirin cutar kansa na cutar Alzheimer an tabbatar da shi sosai a cikin nazarin dabba.8 Duk da haka, ba a san abubuwan da ke tattare da bioactive don wannan aikin ba har yanzu.
Ana sa ran cutar ta mantuwa za ta iya shafar sama da mutane miliyan 115 a duniya baki daya nan da shekarar 2050. Wata kungiyar masu bincike ta yi nazarin wani binciken dabbobi da aka yi a baya wanda ya ba da rahoto game da cutar Alzheimer ta abubuwan da aka fitar da ruman.
Teamungiyar ta kimanta ikon waɗannan abubuwan haɗin don ƙetare shingen ƙwaƙwalwar jini kuma sun gano cewa wani nau'in methylated na urolithin A (mUA), wanda aka samo daga rumman, tare da sauran urolithins suna iya yin hakan.
Kuma, kodayake ana buƙatar ƙarin bincike, marubutan sun yanke shawarar cewa urolithins sune yiwuwar mahaɗan da ke da alhakin tasirin anti-Alzheimer waɗanda suka haɗa da kariya daga cutar ta jiki da b-amyloid fibrillation. Wadannan sakamakon suna da tabbaci, kuma suna ba da shawarar neman wasu dabarun tsoma baki game da dabi'a don hana ko rage saurin ci gaban cutar Alzheimer.
Sakamako da bayanai daga waɗannan karatun daban suna ƙara tallafawa mahimmancin mahaɗan polyphenol metabolite mahadi kamar urolithin A daga ruman da kuma rawar da suke takawa wajen yaƙi da ciwon daji na hanji da cututtukan neurodegenerative.
Nazarin kuma ya nuna cewa Urolithin A na iya inganta ƙarfin tsoka da jimiri a cikin mutanen da suka tsufa. Binciken da aka yi kwanan nan ya nuna cewa shaidun farko sun gabatar da wasu fa'idodi na Urolithin A, waɗanda suka haɗa da masu zuwa:

-Anti-mai kumburi
-Anticarcinogenic
-Antioxidant
-Bayan ciki
-Rashin kwayoyin cuta


Urolithin A ana kuma ganinsa a matsayin kari ga kayayyakin furotin don haɓaka tasirin motsa jiki, da kuma rage kiba.

Urolithin A Gurbin Gurbin

A cikin gwajin gwajin ɗan adam da aka ambata, babu wani sakamako mai illa da aka ruwaito. A cikin binciken kan jerin tsararru na yau da kullun da kuma na asibiti, da alama akwai shaidar goyan baya ga lafiyar Urolithin A amfani.

Babu wani sakamako mai guba da aka bayar da rahoto, har ma a cikin karatun da ya shafi mafi girman kashi da aka ba beraye a cikin irin wannan karatun.

Urolithin A an saita don canza masana'antar anti-tsufa. Karatun asibiti har yanzu suna matakin farko amma yawancin gwaji suna nuna sakamako mai kyau ba tare da wani tasiri ba. Daga abinci zuwa kari, Urolithin A zai iya kasancewa sabon sabon kayan abinci na gaba wanda yakamata kowa ya sha.

Urolithin Tushen Abinci

Kamar yadda aka ambata, Urolithin A a ƙarshen siffarsa ba ya bayyana ta yanayi. Ba a san cewa ana samun sa a cikin kowane tushen abinci ba. Koyaya, za'a iya samun magabatar gidan a cikin wasu 'ya'yan itace da kwayoyi. Tushen abinci wanda ya ƙunshi ellagitannins kamar rumman, raspberries, strawberries, girgije, da goro wasu misalai ne.

Ellagitannins a cikin wadannan 'ya'yan itatuwa da kwayoyi suna da ruwa a cikin hanji don samar da sinadarin ellagic, wanda daga nan sai a ci gaba da aiwatar da shi a cikin hanjin kuma a cakuda shi tare da gut microflora cikin Urolithin A.

Yana da mahimmanci a lura cewa Urolithin A ba koyaushe yake faruwa ba idan aka shanye shi. Wadansu mutane ba su da lafiyayyen hade-hade na microflora da ake bukata don juya acid mai narkewa zuwa Urolithin A. Wannan yana nufin cewa ba kowa ne zai samar da Urolithin A a cikin hanjinsu ba idan suka ci rumman, goro, ko 'ya'yan itace. Duk ya dogara da ƙwayoyin hanji da ke cikin jikinku.

Urolithin Tsarin Masana'antu

Urolithin A ana kera shi ta hanyar hada sinadarai ta amfani da daya daga cikin matakai biyu da aka bayyana a kasa. Dukkanin hanyoyin guda biyu sun hada da aikin hada Ullmann, sannan kuma maganin Lewis acid don samar da ingantaccen urolithin A samfurin.

An tsarkake samfurin karshe ta hanyar daidaitattun hanyoyin magani a cikin kaushi, tace, wanka, da bushewa don samun tsarkakakken urolithin A. Daga baya ana fuskantar samfurin zuwa rage girman kwayar.

Dangane da ingantaccen tsari, Urolithin A foda an kera shi da roba kuma an tsarkake shi a manyan matakai da yawa zuwa cikakken bayani mai tsabta na 99%. Abubuwan Kaya da matakan sarrafawa wadanda suka hada da hada urolithin A sun hada da 2-Bromo-5-methoxy benzoic acid, 2-Bromo-5-hydroxy benzoic acid, Resorcinol, 50% sodium hydroxide, Copper sulfate pentahydrate, Methanol, Aluminum chloride, Toluene , DMSO, Methanol, Acetic Acid, da TBME (tert-butyl-methyl ether).

Roba Urolithin A VS Halittar Urolithin A

Kamar yadda aka ambata a sama, Urolithin A shine ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta ellagitannins (ET) ko ellagic acid (EA). Idan kana son samun adadi mai yawa na Urolithin A, dole ne ka fara cin 'ya'yan itatuwa masu yawa, sannan ka jira su su canza daga ellagitannins da ellagic acid zuwa Urolithin A. Wannan tsari yana da tsawo, kuma tsarkinsa yana da ƙasa, kuma mafi mahimmanci , yin hakan zai yi tsada sosai.

Ba kowa bane ke da microflora madaidaiciya wanda zai iya haifar da narkewar jiki. Bugu da kari, wannan aikin ba zai taba yin amfani da shi ba wajen samar da taro a cikin masana'antar kere kere mai yarda da GMP.

Labari mai dadi shine cewa, a matsayin sabon abu, Urolithin A ana samun kasuwancin ta ƙarshe a cikin 2019 daga Cima Science. Yanzu ana iya hada shi a cikin lab da ma'aikata. Urolithin na roba A yayi kama da tsari zuwa urolithin na halitta A. Iyawar kere kere yakai 3000 kgs ko tan 2.5 / wata.

Urolithin A Tsaro

Urolithin A Tarayyar Turai ta amince da ita azaman sabon kayan abincin abinci.

Hukumar Abinci da Magunguna ta Amurka (FDA) a cikin 2018 a cikin 500 ta ba urolithin A matsayin ta na GRAS wanda aka yi amfani da shi wajen tsarin karin abincin. GRAS yana nufin cewa Urolithin A gabaɗaya ana ɗaukarsa mai haɗari tare da sashi na 1mg zuwa gram XNUMX da sabis.

Urolithin An gudanar da bincike kan aminci a cikin jerin tsararru na gwaji da na asibiti, wanda ke karfafa lafiyar lafiyar sa don amfanin sa. Maimaita sashi na 28 da kwana 90 na urolithin A a cikin beraye bai nuna wani tasirin tasirin illa a cikin wasu sigogin da aka auna ta kowace hanya allurai da aka gwada.

Plementarin har zuwa kwanaki 90 tare da urolithin A ba ya haifar da alamun alamun cututtukan jijiyoyin jiki ko na haihuwa a cikin ingantaccen lokacin bincike na karatun-sake-sake kamar ƙimar spermatogenesis ko zagayen oestrus, gwajin ophthalmoscopic, nuna batirin aiki, da aikin motsa jiki kimantawa.

Maraba da Sayi Urolithin A / Urolithin 8-Methyl Ether Bulk Foda daga AASraw!

Gano urolithin A, wanda ke fitowa daga punicalagins da ellagitannins mahaɗan da aka samu a cikin rumman, yana ba da sababbin dama don yaƙi da raunin shekaru na aikin mitochondrial da sakamakon rashin ƙarfi da asarar tsoka.

Ta hanyar taimaka wa ƙwayoyin su sabunta kansu da kuma inganta aikin tsoka, cirewar rumman da sabon kwayar da ta gano, urolithin A-na iya tabbatar da nasara.

Tare da waɗannan binciken, akwai shaidar taimako mai ƙarfi game da tasirin da urolithin A ke da shi game da cutar Alzheimer da cutar kansa, tare da ba da wani kayan aiki don yaƙi da waɗannan mummunan yanayin da ya shafi yawancin tsofaffi.

Wannan tsarin abinci mai gina jiki yana buɗe damar da hanyoyin maganin gargajiya ba su taɓa bincika ba. Idan kana son siyan Urolithin A foda / Urolithin A 8-Methyl Ether foda, AASraw watakila kyakkyawan zaɓi.

Bayanin Urolithin B

Urolithin B shine sinadarin urolithin, wani nau'in mahadi ne da ake samarwa a cikin kwayar dan adam bayan shan kwayar ellagitannins wacce ke dauke da abinci irin su rumman, huda, shukakkun ja, walnuts ko giya mai tsufa. Ana samun Urolithin B a cikin fitsari a cikin sinadarin urolithin B glucuronide.

Urolithin B shima samfurin halitta ne tare da aikin antiproliferative da antioxidant. Urolithin B an kafa shi ne ta hanyar metabolism daga polyphenols da ake samu a wasu kwayoyi da 'ya'yan itace, musamman rumman. Urolithin B an nuna shi ya haye shinge na kwakwalwar jini, kuma yana iya samun tasirin kwayar cutar cutar Alzheimer.

Tsarin Urolithin B na Aiki

Yana rage lalacewar furotin kuma yana haifar da hawan jini. Urolithin B ya hana aikin aromatase, enzyme wanda ke canza yanayin estrogen da testosterone.

Urolithin B shine samfurin halitta tare da aikin antiproliferative da antioxidant. Urolithin B yana samuwa ne ta hanyar metabolism daga polyphenols da ake samu a wasu kwayoyi da 'ya'yan itace, musamman ruman. Urolithin B an nuna shi ya haye shinge na kwakwalwar jini, kuma yana iya samun tasirin kwayar cutar cutar Alzheimer.

Urolithin B yana hana ayyukan NF-κB ta hanyar rage yawan phosphorylation da lalata na IκBα, kuma yana danne phosphorylation na JNK, ERK, da Akt, kuma yana inganta phosphorylation na AMPK. Urolithin B shine mai kula da ƙwayar ƙwayar ƙwayar ƙwayar cuta.Urolithin B shine ɗayan ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta.

Aikace-aikacen Urolithin B

Yayinda ake nazarin abubuwan da ke haifar da kumburi da antioxidant na urolithins A da B, masu binciken UCL sun gano cewa ƙarshen yana da tasirin kariya akan tsokoki. 'Kwayoyin tsoka a al'adun da ke mu'amala da urolithin B sun fi waɗanda ba su girma ba. Muna so mu san dalilin.

Na farko, sun yi nazarin abu a cikin vitro kuma sun gano urolithin B yana da sakamako biyu: yana kunna haɓakar sunadarin tsoka kuma yana rage lalacewa.

Na biyu, masu binciken sunyi nazarin tasirin urolithin B a cikin vivo, akan beraye. 'Ya kara musu ci gaban tsoka', in ji Farfesa Francaux. 'Mun kuma gudanar da shi ga beraye tare da yankewar jijiyar juzu'i wanda ya haifar da ciwon gurɓataccen kafa, kuma asarar tsoka da ta biyo baya ta faru 20 zuwa 30% ƙasa da sauri kuma zuwa ƙarami.'

Hanyoyin Urolithin B

Urolithin B shine ɗayan ƙwayoyin maganin ƙwayoyin cuta na ellagitannins, kuma suna da cututtukan kumburi da antioxidant. Urolithin B yana hana ayyukan NF-κB ta hanyar rage yawan phosphorylation da lalata na IκBα, kuma yana danne phosphorylation na JNK, ERK, da Akt, kuma yana inganta phosphorylation na AMPK. Urolithin B shima mai daidaitawa ne akan ƙwayar tsoka.

(1). Urolithin B yana rage asarar nauyin nauyin tsoka wanda aka haifar ta denervation
(2). Urolithin B ya haifar da hauhawar ƙwayar jijiya a cikin ƙuda
(3). Sakamakon anabolic urolithin B yana shiga tsakani ta mai karɓar asrogen
(4). Urolithin B yana haɓaka haɓakar furotin a cikin C2C12 myotubes ta kunna siginar mTORC1
(5). Urolithin B yana hana lalacewar furotin ta hanyar rage kimar hanyar ubiquitin – proteasome
(6). Urolithin B yana haɓaka bambancin myotubes na C2C12

reference:

[1] Spendiff, S. da dai sauransu. Cirewar DNA ta mitochondrial a cikin ƙwayoyin tauraron ɗan adam tsoka: abubuwan da ke tattare da hanyoyin kwantar da hankali. Hum. Mol. Kwayar halitta. 22, 4739–4747 (2013).
[2] Milburn, MV & Lawton, KA Aikace-aikacen metabolomics don gano rashin juriya na insulin. Annu. Rev. Med. 64, 291-305 (2013).
[3] Laker, RC et al. Ampk phosphorylation na Ulk1 ana buƙata don ƙaddamar da mitochondria zuwa lysosomes a cikin motsa jiki-jawo mitophagy. Nat. Kwaminisanci 8, 548 (2017).
[4] Singh, R. et al. Haɓaka haɓakar ƙuƙwalwar hanji ta hanyar haɓakar ƙwayar cuta ta hanyar Nrf2. Nat. Kwaminisanci 10, 89 (2019).
[5] Andreux, PA et al. Ayyukan mitochondrial suna da rauni a cikin ƙwayar ƙwayar tsofaffin tsofaffi. Sci. Rep. 8, 8548 (2018).
[6] Gong, Z. et al. Urolithin Wani haɓaka ƙwaƙwalwar ƙwaƙwalwar ajiya da ƙarancin jijiyoyin jiki a cikin ƙwayoyin APP / PS1. J. Neuroinflammation 16, 62 (2019).
[7] Felder, TK et al. Specific kewaya phospholipids, acylcarnitines, amino acid da amines na biogenic sune alamun motsa jiki na aerobic. J. Sci. Likita Wasanni 20, 700-705 (2017).
[8] Schooneman, MG, Vaz, FM, Houten, SM & Soeters, MR Acylcarnitines: yin tunani ko haifar da juriya na insulin? Ciwon sukari 62, 1-8 (2013).
[9] Jagora kan dabaru don ganowa da rage haɗarin haɗarin gwaji na asibiti na Farko tare da Samfuran Magungunan Bincike EMEA / CHMP / SWP / 28367/07 (Hukumar Magunguna ta Turai, 2007).
[10] Keefe, DM GRAS Sanarwa A'a GRN 000791 (Gudanar da Abinci da Magunguna, 2018).
[11] Drake, JC & Yan, Z. Mitophagy wajen kula da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta jiki da kuma lafiyar lafiyar jiki tare da tsufa. J. Physiol. 595, 6391-6399 (2017).
[12] Choi, AM, Ryter, SW & Levine, B. Autophagy a lafiyar ɗan adam da cuta. N. Engl. J. Med. 368, 651-662 (2013).