Samfur Description
Vardenafil Hydrochloride Foda bidiyo-AASraw
raw Vardenafil HCL Foda Basic Characters
| name: | Vardenafil hydrochloride (Levitra) foda |
| CAS: | 224785-91-5 |
| Formula kwayoyin: | C22H19N3O4 |
| Kwayoyin Weight: | 389.4 |
| Shawarwar Melt: | 298-300 ° C |
| Ajiye Temp: | 20ºC |
| Color: | White Foda |
Menene Vardenafil hydrochloride foda?
Vardenafil hydrochloride foda, wanda ake kira vardenafil HCL foda, yana daya daga cikin nau'in phosphodiesterase enzyme 5 (PDE5) inhibitors.Wannan enzyme yana da alhakin lalata cyclic guanosine monophosphate (cGMP), kwayoyin da ke taka muhimmiyar rawa a cikin tsari.
A lokacin sha'awar jima'i, nitric oxide yana fitowa a cikin nama mai tsayi na azzakari (corpus cavernosum), wanda kuma yana motsa enzyme guanylate cyclase. daga cikin wadannan tsokoki suna ba da damar ƙarin jini ya kwarara zuwa cikin azzakari, yana haifar da tashin hankali.
Ta hanyar hana PDE5, AASraw vardenafil hydrochloride foda ya hana rushewar cGMP, don haka kiyaye matakan girma na wannan kwayoyin halitta da kuma tsawaita tasirinsa.Wannan yana haifar da ci gaba da shakatawa na tsoka da jini, don haka yana taimakawa wajen kula da haɓaka a lokacin jima'i.
Ta yaya Vardenafil hydrochloride Foda ke aiki?
Vardenafil hydrochloride foda yana aiki azaman mai hanawa mai zaɓin enzyme da ake kira nau'in phosphodiesterase 5 (PDE5) .Ga jagorar mataki-mataki ga yadda yake aiki:
① Ƙunƙarar jima'i yana haifar da sakin nitric oxide a cikin corpus cavernosum, yanki na azzakari.
②Wannan nitric oxide yana haifar da wani enzyme mai suna guanylate cyclase don canza guanosine triphosphate (GTP) zuwa cyclic guanosine monophosphate (cGMP).
③CGMP yana haifar da santsin tsokoki a cikin cavernosum na corpus don shakatawa, wanda ke ba da damar tasoshin jini su fadada.
④ Fadadawar hanyoyin jini yana kara kwararar jini zuwa cikin azzakari, yana kaiwa ga tashin hankali.
⑤ A al'ada, enzyme PDE5 ya rushe cGMP, yana ƙarewa.
⑥ Daga ƙarshe, vardenafil hydrochloride yana haɓakawa da kuma ci gaba da tsarin ilimin halitta wanda ke haifar da haɓakawa don amsawa ga jima'i.
Yana da mahimmanci a fahimci cewa vardenafil hydrochloride ba ya haifar da tashin hankali kai tsaye.Maimakon haka, yana inganta yanayin yanayin jiki ga jima'i. Har ila yau, yana da mahimmanci don saya vardenafil hydrochloride foda daga mai samar da abin dogara kamar AASraw, wanda ya ba da tsabtar verdenafil hcl foda ga mutane da yawa. shekaru.
Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil
Mafi yawan masu hana PDE5 guda huɗu a kasuwa sune sildenafil,Tadalafilvardenafil, da avanafil.Waɗannan magunguna guda huɗu duk masu hana PDE5 ne kuma sune farkon layin jiyya don ED. Duk da haka, sifofin sinadarai na waɗannan magunguna huɗu sun bambanta, suna haifar da nau'ikan sinadarai da ayyuka na jiki. excretion a cikin jiki dabam, kamar yadda su curative effects.
| PDE5 Mai hanawa | Farkon Aiki | Tmax (h) | Cmax (ng/ml) | T1/2 (h) | Tsawon lokaci (h) | Babban Maganganun Magani |
| Sildenafil | 30 min-1h | 0.8-1 | 560 | 2.6-3.7 | 4 | Ciwon kai, Fitowar fuska, rashin narkewar abinci, cunkoson hanci, dizziness, rashin ganin ido. |
| Vardenafil | 15 min | 0.9 | 200 | 3.9 | 8 | Ciwon kai, Fitowar fuska, rashin narkewar abinci, cunkoson hanci, dizziness, rashin ganin ido. |
| Tadalafil | 1h | 2 | 378 | 17.5 | 36 | Ciwon kai, Fitowar fuska, rashin narkewar abinci, cunkoson hanci, juwa, babu rashin lafiyar gani. |
| Avanafil | 10-15 min | / | > 1000 | 3-5 | 6-8 | Ciwon kai, fiskar fuska, rashin narkewar abinci, cunkoson hanci, dizziness (kasa da yawa idan aka kwatanta da sauran) |
lura:
Tmax = lokacin da za a kai matsakaicin maida hankali na plasma
Cmax = matsakaicin maida hankali na plasma
T1/2 = rabin rayuwa
Wannan tebur yana taƙaita halaye na pharmacokinetic na masu hana PDE5 guda hudu da aka tattauna. Yana da mahimmanci ga masu samar da kiwon lafiya suyi la'akari da waɗannan bambance-bambancen lokacin da ake rubuta waɗannan magunguna, kuma marasa lafiya ya kamata su yi amfani da waɗannan magunguna a ƙarƙashin kulawar likita. Bugu da ƙari, sayen vardenafil hcl foda daga wani. mai sayarwa mai dogara kamar AASraw yana tabbatar da cewa za ku sami samfurin inganci mai kyau da tsabta.AASraw , a matsayin mai sana'a na vardenafil hcl foda mai kaya, zai iya samar da vardenafil hydrochloride foda tare da babban inganci a duk faɗin duniya.
Yadda za a zabi PDE5 masu hanawa?
Zaɓin madaidaicin PDE5 mai hanawa zai iya dogara da dalilai daban-daban, ciki har da lafiyar lafiyar marasa lafiya, kasancewar wasu yanayi, salon rayuwarsu, da kuma amsawar kowannensu ga magani. Ga jagorar gabaɗaya don zaɓar mai hana PDE5 don tunani, amma ku tuna. don tuntuɓar mai ba da lafiya koyaushe don yin zaɓi mafi kyau don buƙatun mutum.
| Yanayin Mara lafiya | Nasihar PDE5 Inhibitor | dalili |
| Sha'awar lokacin farawa da sauri | Avanafil | Mafi saurin farawa tsakanin masu hana PDE5 |
| Tsakanin shekaru da tsofaffi tare da ED da cututtuka na kullum (hawan jini, hyperlipidemia) | Sildenafil | Matsakaicin sigogi na pharmacokinetic, ƙarancin kuzari ga jiki |
| Tsakanin shekaru da tsofaffi tare da ED da rashin aiki na endothelial na jijiyoyin jini (egdiabetes) | Tadalafil | Dogon lokaci na aiki, zai iya inganta aikin endothelial na jijiyoyin jini da alamun urinary fili a tsawon lokaci |
| Tsakanin shekaru da tsofaffi tare da ED, babu cututtuka na jijiyoyin jini | Vardenafil | Tasiri mai laushi, saurin farawa, ƙarancin bioavailability, kaɗan mara kyau |
| Tsakanin shekaru da tsofaffi tare da ED, rashin aiki na endothelial na jijiyoyin jini, sildenafil ba shi da tasiri | Avanafil | Babban taro na jini, tasiri mai karfi |
| Matasa da masu matsakaicin shekaru tare da ED, babu takamaiman ilimin ilimin halitta | Sildenafil | Mai tasiri ga ED wanda ya haifar da abubuwan tunani |
| Ayyukan gani mara kyau da ED | Tadalafil | Babu rashin daidaituwa na gani tsakanin mummunan halayen |
| Zaɓin magani na baya-bayan nan | Avanafil, Vardenafil | Yawan sha ba a sauƙaƙe ta hanyar abinci ba |
Bayanan kula: An ba da wannan bayanin game da masu hana PDE5 don dalilai na bayanai na gaba ɗaya kawai kuma baya zama shawara na likita.Zaɓin mai hana PDE5 ya kamata a koyaushe a yi shi tare da mai ba da lafiya wanda zai iya yin la'akari da lafiyar mutum gaba ɗaya, sauran magunguna kasancewa. da aka dauka, da takamaiman yanayi da tsananin rashin aikin mazan jiya. Duk da yake waɗannan magungunan na iya yin tasiri wajen magance matsalar rashin ƙarfi, suna da illa da haɗari da haɗari, kuma ba su dace da kowa ba.Wasu yanayin kiwon lafiya da sauran magunguna na iya yin hulɗa da su. PDE5 inhibitors, yana haifar da mummunan sakamako masu illa. Koyaushe nemi shawarar ma'aikacin kiwon lafiya don kowace tambaya da za ku iya yi game da yanayin likita.
Sashi da gudanarwa na Vardenafil hydrochloride foda don tunani
Matsakaicin vardenafil HCL foda na iya bambanta dangane da lafiyar mutum, amsawa ga magani, da sauran magunguna da za su iya ɗauka.A nan akwai shawarwari na gaba ɗaya, amma yana da mahimmanci don bin takamaiman umarnin mai bada sabis na kiwon lafiya.
①Standard dose za edubura drashin aiki
Shawarar da aka ba da shawarar farawa na vardenafil shine 10 MG, ana ɗaukar shi ta baki kusan mintuna 60 kafin yin jima'i. Za'a iya ƙara yawan adadin zuwa matsakaicin 20 MG ko rage zuwa 5 MG, dangane da inganci da haƙuri. kowace rana.
②Marasa lafiya tare da mrashin hankali hepatic ilalacewa
Ga marasa lafiya da matsakaicin ciwon hanta (Child-Pugh B), an ba da shawarar farawa na 5 MG na vardenafil. Matsakaicin adadin marasa lafiya tare da rashin ciwon hanta bai kamata ya wuce 10 MG ba.
③Marasa lafiya tare da shar abada renal ilalacewa
Ga marasa lafiya da mai tsanani (CLcr <30 mL / min) rashin lafiya na koda, an bada shawarar farawa na 5 MG na vardenafil.
④Marasa lafiya a kan stebur alfa-bkabad trashin lafiya
Shawarar da aka ba da shawarar farawa na vardenafil ga marasa lafiya da ke karɓar tsayayyen maganin alpha-blocker shine 5 MG.
⑤Marasa lafiya tare da concomitant uSaukewa: CYP3A4 imasu hanawa
Ga marasa lafiya da ke shan masu hana masu hana CYP3A4 masu ƙarfi (kamar ketoconazole,itraconazole,ritonavir,indinavir,saquinavir,da atazanavir), kada a wuce kashi na farko na 5 mg vardenafil.
Notes
Yana da mahimmanci a lura cewa ana buƙatar motsa jiki na jima'i don amsawa ga magani.Vardenafil ba ya ƙara yawan sha'awar jima'i kuma ba zai haifar da tashin hankali ba tare da jima'i ba.Siyar da vardenafil HCL foda daga mai samar da abin dogara zai iya tabbatar da cewa kuna samun babban inganci. samfurin da zai taimaka wajen cimma mafi kyawun inganci don amfani da shi.AASraw yana nufin samar da babban ingancin vardenafil hcl foda a duniya a ƙarƙashin tsarin CGMP.Idan kuna da buƙatu, AASraw babban zaɓi ne don siyan vardenafil hcl foda.
Inda zan saya Vardenafil hydrochloride Foda?
Vardenafil hydrochloride foda za a iya saya daga nau'o'in masu samar da layi na kan layi wanda ke da ƙwarewa wajen sayar da kayan aikin magunguna.Lokacin da za a yanke shawarar saya daga mai sayarwa na kan layi, yana da mahimmanci don tabbatar da cewa suna da tushe mai daraja, saboda muhimmancin inganci da tsabta na samfur don aikace-aikacen kiwon lafiya.Tabbatar da mai siyarwar ya ba da ƙayyadaddun samfur da takaddun tabbacin inganci, kamar Takaddun Takaddun Bincike.
Idan kuna neman tushen abin dogara don siyan vardenafil foda,AASraw na iya zama zaɓin da ya dace.AASraw kamfani ne wanda ke ba da nau'o'in nau'in kayan aikin magunguna, ciki har da vardenafil foda. Yawanci ana amfani da su ta hanyar dakunan gwaje-gwaje da cibiyoyin bincike don haɓakawa da kuma samar da kayan kiwon lafiya daban-daban.
raw Vardenafil HCL Rahoton Gwajin Foda-HNMR
Menene HNMR kuma Menene Bakan HNMR ke gaya muku?H Nuclear Magnetic Resonance (NMR) spectroscopy dabara ce ta nazarin sinadarai da ake amfani da ita wajen sarrafa inganci da bincike don tantance abun ciki da tsarkin samfurin da kuma tsarinsa na kwayoyin halitta. Misali, NMR na iya tantance gaurayawan da ke dauke da sanannun mahadi. Don mahaɗan da ba a san su ba, NMR ana iya amfani da su ko dai don daidaitawa da ɗakunan karatu na bakan gizo ko don fahimtar ainihin tsarin kai tsaye. Da zarar an san ainihin tsarin, ana iya amfani da NMR don ƙayyade daidaituwar kwayoyin halitta a cikin bayani tare da nazarin kaddarorin jiki a matakin kwayoyin halitta kamar musanya mai daidaituwa, canje-canjen lokaci, solubility, da yadawa.
Vardenafil Hydrochloride foda (224785-91-5) -COA
Vardenafil Hydrochloride foda (224785-91-5) -COA
Yadda za a saya Vardenafil HCL Foda daga AASraw?
❶Don tuntuɓar mu ta tsarin binciken imel ɗin mu, ko kuma ku bar mana lambar ku ta whatsapp, wakilin sabis na abokin ciniki (CSR) zai tuntuɓar ku cikin awanni 12.
❷Don samar mana da adadin ku da adireshin ku.
❸CSR ɗin mu zai ba ku fa'ida, lokacin biyan kuɗi, lambar bin diddigi, hanyoyin bayarwa da ƙididdigar ranar isowa (ETA).
❹An gama biyan kuɗi kuma za a aika da kayan a cikin awanni 12.
❺Kayan da aka karɓa kuma a ba da sharhi.
Marubucin wannan labarin:
Dr. Monique Hong ya sauke karatu daga Kwalejin Kimiyya ta Burtaniya ta London Faculty of Medicine
Mawallafin Jaridar Kimiyya:
1. Hazem M. Abu Shawish
Chemistry Department, College of Sciences, Al-Aqsa University, Gaza, Palestine
2. E. BISCHOFF
From the Institute of Cardiovascular Research II, and Departments of Chemical Research, and Product Development and Preclinical Pharmacokinetics, BAYER AG Pharmaceutical Business Group, Wuppertal, Germany
3. M.M. Mabrouk
Department of pharmaceutical analytical chemistry, faculty of pharmacy, Tanta university, Tanta, Egypt
4. Engin Yurtcu
Obstetrics and Gynecology Department of Zekai Tahir Burak Women’s Health and Research Hospital, Ankara, Turkey
5. Silvia Limoncella
Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Babu wata hanya da wannan likita/masanin kimiyyar ya yarda ko ba da shawarar siyan, siyarwa, ko amfani da wannan samfur saboda kowane dalili. Aasraw ba shi da wata alaƙa ko alaƙa, a fayyace ko akasin haka, tare da wannan likitan. Manufar ambaton wannan likita shine yarda, yarda da kuma yaba da cikakken bincike da ayyukan ci gaba da masana kimiyyar da ke aiki akan wannan abu suka yi.
reference
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[2] Makarantun Magunguna (Glen L.Stimmel, D., da Mary A.Gutierrez, Pharm.D.) da Magunguna (Glen L.Stimmel, Pharm.D.), Jami'ar Kudancin California, Los Angeles, California. "Shawarwari ga Marasa lafiya Game da Al'amuran Jima'i: Magani-Induced Priapism".Medscape.Retrieved 2010-12-06.
[3] “Sabuwar maganin matsalar rashin karfin mazakuta Staxyn da aka amince da ita a Amurka.- Gudanar da Magunguna". com.2010-06-21.An adana daga asali ranar 2012-04-06.
[4] Tucker J, Fischer T, Upjohn L, Mazzera D, Kumar M (Oktoba 2018). "Kayananan Magungunan da ba a yarda da su ba sun haɗa a cikin Kariyar Abinci masu alaƙa da Gargadin Hukumar Abinci da Magunguna ta Amurka". Kungiyar JAMA ta bude. 1 (6):
[5] Lepor H, Lepor NE, Hill LA, Trohman RG (2008). "Tazarar QT da Zaɓin Alpha-Blockers don Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙira". Reviews a Urology. 10 (2): 85–91.
