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Sunitinib Malate

 

  1. Sunitinib Malate Overviews
  2. Me Zamu Iya Amfani da Sunitinib Malate?
  3. Yaya Sunitinib Malate yake aiki?
  4. Yadda Ake Shan Maitin Sunitinib?
  5. Taya zaka Adana Sunitinib Malate?
  6. Nawa Mun San Illolin Sunitinib Malate?
  7. Waɗanne Sauran Magunguna Ne Za Su Shafar Maitin Sunitinib?
  8. FDA ta amince da Sunitinib Malate A Matsayin Maganin Adjuvant na Ciwon ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta
  9. A Ina Zan Sayi Sunitinib Malate akan layi?

 

Sunitinib Malate (CAS:341031-54-7) an gano shi ne a SUGEN, wani kamfanin kimiyyar kere-kere wanda ya gabatar da masu hana yaduwar protein. Ya kasance na uku a cikin jerin mahaɗan gami da SU5416 da SU6668. Ma'anar ta kasance kamar misalin ATP ne wanda zai yi gasa tare da ATP don ɗaurewa ga rukunin yanar gizo mai karɓar mai karɓar tyrosine kinases. Wannan tunanin ya haifar da kirkirar masu karamin kwayar cutar tyrosine kinase, wadanda suka hada da Gleevec, Sutent, Tarceva da sauransu.

 

Sunitinib Malate Overviews

Sunitinib Malate ruwan hoda ne zuwa hoda mai ruwan lemo. Sunitinib Malate shine karamin kwayar halitta da yawa mai karɓar tyrosine kinase (RTK) mai hanawa A ranar 26 ga Janairu, 2006, FDA ta Amurka ta ba da izini ga wakilin don alamun alamun magance ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta imatinib (GIST). Don waɗannan dalilai, ana samun Sunitinib Malate gabaɗaya azaman sarrafa maganganu da baki. Sunitinib Malate yana hana siginar salula ta hanyar niyya ga RTKs da yawa. Waɗannan sun haɗa da duk masu karɓar haɓakar haɓakar platelet (PDGF-R) da kuma masu karɓar rashi na ƙarshen ƙarancin jijiyoyin jiki (VEGF-R). Sunitinib Malate kuma yana hana KIT (CD117), RTK wanda ke motsa yawancin GISTs. Bugu da kari, Sunitinib Malate ya hana wasu RTKs ciki har da RET, CSF-1R, da flt3.

 

Me Zamu Iya Amfani da Sunitinib Malate? 

Ana amfani da Sunitinib Malate don magance manya da ke fama da cutar sankarar koda wanda ba ta yaɗu ba (na gida) kuma waɗanda ke cikin haɗarin kamuwa da RCC sake dawowa bayan an yi musu tiyatar koda.

Ana amfani da Sunitinib Malate don magance ciwon kansar koda (ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ko RCC).

Ana amfani da Sunitinib Malate don magance wata sankara mai saurin ciki, hanji, ko hanji da ake kira ciwon ciki na stromal (GIST) kuma lokacin da kuka sha maganin imatinib mesylate kuma bai hana ciwon daji girma ba ko kuma baza ku iya shan imatinib mesylate ba. Gleevec alamar kasuwanci ce mai rijista ta Kamfanin Kamfanin Magunguna na Novartis.

Ana amfani da Sunitinib Malate don magance wani nau'in cutar sankara wanda aka sani da ciwan ciwan neuroendocrine (pNET) wanda ya ci gaba kuma ba za a iya magance shi da tiyata ba.

 

Yaya Sunitinib Malate yake aiki?

Sunitinib Malate dan karamin kwaya ne mai hana yaduwar sinadarin tyrosine kinases, wasu daga cikinsu suna da nasaba da ci gaban tumo, cututtukan cututtukan ciki, da ci gaba na ciwan kansa. Wakilin yana hana masu karɓar haɓakar haɓakar platelet - (PDGFRα da PDGFRβ), masu karɓar raƙuman haɓakar ƙarancin jijiyoyin jijiyoyin jiki (VEGFR1, VEGFR2, da VEGFR3), mai karɓar sel mai amfani da kwayar halitta (KIT), kamar Fros-like tyrosine kinase 3, mai karɓar tasirin mai karfin mallaka. Rubuta 1, da glial cell-line wanda aka samo mai karɓar factor neurotrophic (RET). Sunitinib Malate hanawa na aiki da aikin waɗannan masu karɓar tyrosine kinases an nuna su a cikin gwaje-gwajen biochemical da salon salula da ƙwayoyin ƙwayoyin cuta. Maganin farko na Sunitinib Malate yana nuna ƙarfi kwatankwacin mahaɗan mahaifa a cikin gwajin biochemical da salon salula.

Sunitinib Malate ya hana phosphorylation na yawancin mai karɓar tyrosine kinases (PDGFRβ, VEGFR2, KIT) a cikin tumo xenografts wanda ke bayyana mai karɓar maganin tyrosine kinase a cikin rayuwa kuma yana hana haɓakar tumo da metastasis a cikin wasu samfuran gwaji. Wakilin ya hana ci gaban ƙwayoyin tumo wanda ke bayyana mai karɓar mai karɓar maganin tyrosine kinases (PDGFR, RET, ko KIT) a cikin vitro da PDGFRβ-da VEGFR2-dependent ƙari angiogenesis in vivo.

 

Sunitinib Malate

 

Yadda Ake Shan Maitin Sunitinib?

Mizanin likita na Sunitinib Malate zai dogara ne da dalilai da yawa. Wadannan sun hada da:

Iri da kuma tsananin yanayin da kuke amfani da Sunitinib Malate don magancewa

❷ sauran yanayin kiwon lafiyar da zaka iya samu

Sauran magungunan da kuke sha

Likitanku a ƙarshe zai tsara ƙaramin sashi wanda ke ba da tasirin da ake so.

Bayani mai zuwa yana bayanin sashi wanda aka saba amfani dashi ko kuma aka bada shawarar. Koyaya, tabbatar da shan maganin da likitanka yayi maka. Likitan ku zai ƙayyade mafi kyawun sashi don dacewa da bukatun ku.

 

Forms Siffofin ƙwayoyi da ƙarfi

Sunitinib Malate yana zuwa kamar kwantena wanda kuke haɗiye shi. Akwai shi a waɗannan ƙarfin: 12.5 milligrams (mg), 25 mg, 37.5 mg, and 50 mg.

 

Sashi don ciwon daji na ciki

Abun da aka saba amfani dashi na Sunitinib Malate na ciwan ciwan ciki (GISTs) shine 50 MG sau ɗaya a rana don makonni 4. Wannan yana biyo bayan makonni 2 ba tare da magani ba. Bayan haka, zaku maimaita sake zagayowar.

Da alama zaku iya ci gaba da shan Maitin na Sunitinib har sai cutar sankara ta tabarbare ko kuma jikinku ba zai iya jure magani da magani ba. Likitan ku zai tantance lokacin da ya kamata ku daina shan Sunitinib Malate. Don cikakkun bayanai kan yadda ake amfani da Sunitinib Malate don magance GISTs, duba mahaɗin azaman ƙasa.

 

Sashi don ciwon kansa

Ana amfani da Sunitinib Malate don magance wani nau'in ciwon daji na koda wanda ake kira carcinoma na renal mai narkewa (RCC). Abubuwan da aka saba amfani da shi na Sunitinib Malate don RCC mai ci gaba shine MG 50 sau ɗaya a rana don makonni 4. Wannan yana biyo bayan makonni 2 ba tare da magani ba. Bayan haka, zaku maimaita sake zagayowar.

Da alama zaku iya ci gaba da shan Maitin na Sunitinib har sai cutar sankara ta tabarbare ko kuma jikinku ba zai iya jure magani da magani ba. Likitan ku zai tantance lokacin da ya kamata ku daina shan Sunitinib Malate. Don ƙarin bayani kan yadda ake amfani da Sunitinib Malate don magance RCC mai ci gaba, duba mahaɗin azaman ƙasa.

 

Sashi don adjuvant na maganin kansar koda

Ana amfani da Sunitinib Malate a matsayin magani na adjuvant na wani nau'in cutar sankarar koda da ake kira RCC bayan wani aikin nephrectomy (cirewar koda ta tiyata). Wanda aka saba sashi na Sunitinib Malate don wannan amfani shine MG 50 sau ɗaya a rana don makonni 4. Wannan yana biyo bayan makonni 2 ba tare da magani ba. Yawanci zaku maimaita wannan zagayen har sau tara. Don cikakkun bayanai kan yadda ake amfani da Sunitinib Malate a matsayin adjuvant magani ga RCC, duba mahaɗin a ƙasa.

 

Sashi don ciwon sankara

Abun da aka saba amfani dashi na Sunitinib Malate don ciwan ciwan ciwan neuroendocrine (pNETs) shine 37.5 MG sau ɗaya a rana.

Da alama zaku iya ci gaba da shan Maitin na Sunitinib har sai cutar sankara ta tabarbare ko kuma jikinku ba zai iya jure magani da magani ba. Likitan ku zai tantance lokacin da ya kamata ku daina shan Sunitinib Malate.

 

Lura: sashin kawai tunani ne, da fatan za a taimaka don bincika ƙarin bayanai ta wannan rukunin yanar gizon:www.fda.gov .

 

 

Taya zaka Adana Sunitinib Malate?

Ka riƙe wannan magani a cikin akwati ta zo, an kulle shi, kuma ba ta iya isa ga yara ba. Ajiye shi a dakin da zazzabi da kuma wuce haddi zafi da danshi (ba cikin gidan wanka).

Yana da muhimmanci a kiyaye dukkan maganin da ba a gani da kuma isa ga yara kamar kwantena da yawa (irin su jariri da kullun mako daya da wadanda ke da idanu, creams, patches, and inhalers) ba su da yarinya kuma yara masu iya buɗe su sauƙi. Don kare yaran yara daga guba, kulle kullun lafiya kuma sanya wuri a cikin wuri mai aminci - wanda ke sama da tafi da kuma daga idanunsu kuma ya isa.

Ya kamata a zubar da magunguna marasa magani ta hanyoyi na musamman don tabbatar da cewa dabbobin gida, yara, da sauran mutane ba za su iya cinye su ba. Koyaya, yakamata ku zubar da wannan maganin ta bayan gida. Madadin haka, hanya mafi kyau don zubar da maganinku shine ta hanyar shirin dawo da magani. Yi magana da likitan ka ko ka tuntuɓi sashen shara / sake amfani da datti na gida don koyo game da shirye-shiryen dawo da martabar ku a yankin ku. Duba Tsarin Lafiya na FDA na Yanar gizo magunguna don ƙarin bayani idan ba ku da damar shirin karɓar kuɗi.

 

Nawa Mun San Illolin Sunitinib Malate?

Abubuwan da ke faruwa na Sunitinib Malate ana daukar su kamar yadda za'a iya sarrafawa da kuma lamuran munanan abubuwan da suka faru.

Abubuwan da suka fi dacewa haɗuwa da maganin Sunitinib Malate sune gajiya, gudawa, tashin zuciya, anorexia, hauhawar jini, canza launin fata mai launin rawaya, saurin fatar hannu-ƙafa, da kuma stomatitis. sau da yawa tare da Sunitinib Malate fiye da placebo sun hada da gudawa, anorexia, canza launin fata, mucositis / stomatitis, asthenia, canza ɗanɗano, da maƙarƙashiya. An buƙaci ragin kashi a cikin 50% na marasa lafiya da aka yi karatu a cikin RCC don gudanar da mahimmancin haɗarin wannan wakilin.

Mai tsanani (sa 3 ko 4) abubuwa masu ban tsoro suna faruwa a cikin ≤10% na marasa lafiya kuma sun haɗa da hauhawar jini, gajiya, asthenia, gudawa, da cutar sankara ta haifar da acry erythema. Abubuwa masu lahani da ke tattare da maganin Sunitinib Malate sun hada da lipase, amylase, neutrophils, lymphocytes, da platelets. Hypothyroidism da juyawa erythrocytosis suma an haɗasu da Sunitinib Malate. Yawancin abubuwan da ke faruwa mara kyau za a iya sarrafa su ta hanyar kulawa da tallafi, katsewar kashi, ko rage kashi.

Wani binciken da aka yi kwanan nan a Cibiyar Cibiyar Cancer ta MD Anderson ya kwatanta sakamakon masu cutar kwayar cutar sankara wadanda suka karbi Sunitinib Malate a kan tsari daidai (50 mg / 4 makonni a sati 2) tare da wadanda suka karbi Sunitinib Malate tare da karin hutu da kuma gajeren hutun magunguna. (madadin jadawalin). An ga cewa rayuwa gabaɗaya, ci gaba kyauta da ci gaba da bin kwayoyi sun kasance mafi girma a cikin marasa lafiya waɗanda suka karɓi Sunitinib Malate akan madadin jadawalin. Har ila yau, marasa lafiya sun sami mafi kyawu da ƙananan ƙananan abubuwa masu haɗari waɗanda ke haifar da dakatar da maganin marasa lafiyar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar magungunan kajik ɗin da suka fi dacewa da haƙuri da ƙananan ƙananan abubuwa masu banƙyama wanda ke haifar da dakatar da maganin marasa lafiya na ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.

 

Sunitinib Malate

 

Waɗanne Sauran Magunguna Ne Za Su Shafar Maitin Sunitinib?

Sunitinib Malate na iya haifar da mummunar matsalar zuciya. Haɗarinku na iya zama mafi girma idan kuna amfani da wasu magunguna don cututtuka, asma, matsalolin zuciya, hawan jini, ɓacin rai, tabin hankali, kansar, zazzabin cizon sauro, ko HIV.

Wani lokaci ba lafiya ba ne don amfani da wasu magunguna a lokaci guda. Wasu kwayoyi na iya shafar matakan jininka na wasu kwayoyi da kuke sha, wanda na iya ƙara illa ko sanya magungunan ba su da tasiri.Ka gaya wa likitanka game da duk sauran magungunan ku, musamman: maganin osteoporosis.

Wannan jeri bai cika ba. Wasu kwayoyi na iya shafar Sunitinib Malate, gami da magunguna da magunguna, bitamin, da kayayyakin ganye. Ba duk hanyoyin hulɗar miyagun ƙwayoyi ake lissafa su ba.

 

FDA ta amince da Sunitinib Malate A Matsayin Maganin Adjuvant Na Ciwon ƙwayar Renal Cell Carcinoma

A Nuwamba 16, 2017, da Food and Drug Administration amince Sunitinib Malate (Sunitinib Malate, Pfizer Inc.) ga adjuvant magani daga adult marasa lafiya a babban hadarin da maimaita koda cell sankara wadannan nephrectomy.

Amincewa ya dogara ne akan cibiyoyi da yawa, na duniya, makafi biyu, wurin sarrafa wuribo, gwaji (S-TRAC), a cikin marasa lafiya 615 da babban haɗarin sake RCC bayan nephrectomy. An rarraba marasa lafiya 1: 1 don karɓar ko dai 50 MG Sunitinib Malate sau ɗaya kowace rana, makonni 4 akan jiyya da makonni 2 suka kashe, ko placebo. Rashin lafiyar marasa lafiya na Mediya ga marasa lafiya da ke ɗaukar Sunitinib Malate ya kasance shekaru 6.8 (95% CI: 5.8, ba a kai ba) idan aka kwatanta da shekaru 5.6 (95% CI: 3.8, 6.6) don marasa lafiya masu karɓar placebo (HR = 0.76; 95% CI: 0.59 , 0.98; p = 0.03). A lokacin nazarin DFS, bayanan rayuwa gabaɗaya basu balaga ba.

Mafi munin halayen da suka fi dacewa (≥25%) ga Sunitinib Malate sune gajiya / asthenia, gudawa, mucositis / stomatitis, tashin zuciya, rage ci / rashin abinci, amai, ciwon ciki, ciwon ƙafa, ciwon hawan jini, abubuwan zubar jini, dysgeusia / ɗanɗano ɗanɗano , dyspepsia, da kuma maganin ciwan jini. Lakabin ya ƙunshi gargaɗin dambe don faɗakar da ƙwararrun likitocin kiwon lafiya da marasa lafiya game da haɗarin cutar hanta, wanda na iya haifar da gazawar hanta ko mutuwa.

Adadin shawarar Sunitinib Malate don adjuvant magani na RCC shine 50 MG na magana sau ɗaya a kowace rana, tare da ko ba tare da abinci ba, makonni 4 a kan magani wanda ya biyo bayan makonni 2 na hutu na sati 6.

 

Lura: Ana samun cikakken bayani game da rubutu a:accessdata.fda.gov  PDF 

 

A Ina Zan Sayi Sunitinib Malate akan layi? 

Akwai masu samarwa / masana'antun Sunitinib Malate foda a kasuwa, gano na gaske yana da mahimmanci ga duk mutanen da suke buƙatar wannan samfurin cikin gaggawa. Lokacin da muka yanke shawarar siyan Sunitinib Malate foda a kasuwa, muna buƙatar ƙarin koyo game da shi, ku san yadda ake amfani da shi kuma tsarin aiki ne, kowane haɗari lokacin da muka ɗauki garin Sunitinib Malate powder. Bugu da kari, farashi da inganci dole ne damuwar mu kafin mu siya.

Bayan mun bincika bayanan daga kasuwa, idan aka kwatanta yawancin masu samarwa, AASraw ya zama kyakkyawan zaɓi ga waɗanda suke son siyan yawancin abubuwa Sunitinib Malate foda, ana sarrafa sarrafa su sosai a cikin yanayin cGMP, ana iya sa ido kan ingancin kowane lokaci kuma suna iya samar da duk rahotannin gwaji lokacin da kuke yin oda. Amma farashin Sunitinib Malate foda / farashi, yakamata yayi daidai, a idanuna. Saboda na sami farashi da yawa daga masu samar da Maitin na Sunitinib, idan aka kwatanta da inganci, ina tsammanin aasraw ba zai zama mummunan zaɓi ba.

 

reference

[1] Gudanar da Abinci da Magunguna. Sunitinib (Sutent) Mai tsara bayanai. 2015.

[2] CA Naranjo, U. Busto, da EM Masu Sayarwa, “Hanyar da za a kimanta yiwuwar yiwuwar muguwar magungunan,” Clinical Pharmacology and Therapeutics, vol. 30, babu. 2, shafi na 239-245, 1981.

[3] Z. Ansari da MK George, "Drug-jawo rigakafi-sulhu tsakani thrombocytopenia sakandare zuwa sunitinib a haƙuri da metastatic koda cell sankara: wani hali rahoton," Journal of Medical Case Rahotanni, vol. 7, labarin 54, 2013.

[4] K. Sakai, K. Komai, D. Yanase, da M. Yamada, "Plasma VEGF a matsayin alama don ganewar asali da maganin cutar jijiyoyin vasculitic," Journal of Neurology, Neurosurgery and Psychiatry, vol. 76, a'a. 2, labarin 296, 2005.

[5] Medicungiyar Magunguna ta Turai. Sunitinib (SUTENT). Takaitawa game da Abubuwan Samfuran. 2015.

[6] Pajares B, Torres E, Trigo JM et al. Tyrosine kinase inhibitors da hulɗar miyagun ƙwayoyi: nazari tare da shawarwari masu amfani. Clin Transl Oncol 2012; 14: 94-101.

[7] Teo YL, Ho HK, Chan A. Maganin maganin ƙwayoyi-maganin ƙwayoyin cuta tare da masu hana maganin tyrosine kinase: fahimta ta yanzu, ƙalubale da shawarwari. Br J Clin Pharmacol 2015; 79: 241-253.

[8] Jamie Dlugosch (2009-03-13). "Shin ilimin kimiyyar halittu da Sutent zai iya ajiye Pfizer?". Mai saka jari

[9] BMJ 31-Jan-2009 "NICE da kuma kalubalen magungunan kansar" p271

[10] Blay JY, Reichardt P (Yuni 2009). "Ciwon ciwon ciki na ci gaba mai ci gaba a cikin Turai: nazari game da sabunta shawarwarin magani". Gwani Rev Anticancer Ther. 9 (6): 831-8. Doi: 10.1586 / zamanin.09.34. PMID 19496720. S2CID 23601578.

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